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Study · Animal study (in vivo) · rat · 1982

4 results

[Effect of histamine and thymarin on blood coagulation and fibrinolysis in intact and thymectomized rats].

Kuznik BI, Pisarevskaia LI, Morozov VG, Khavinson VKh, Tsybikov NN

Biulleten' eksperimental'noi biologii i meditsiny1 Sept 1982

PMID7171817 (opens in a new tab)DOI10.1007/bf00835614 (opens in a new tab)PepBankPUB-07171817
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized rats, thymaline abolished hemostatic abnormalities.

    In plain wordsIn rats without a thymus, thymaline removed abnormalities in the blood clotting system.

    Peptide
    Thymalin
    Outcome
    Not applicableHemostatic abnormalities
    Study

    ratn: not reported in source

    thymectomized rats
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Low-molecular thymus factor--thymaline--not only abolishes the shifts on the part of the hemostatic system in the thymectomized animals
    1 context sentence
    Summary · context
    It was discovered in experiments on thymectomized rats that the animals developed hypercoagulation due to the shortening of prothrombinase formation time and to the inhibition of total and Hageman-dependent euglobulin fibrinolysis 2-3 months after the operation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized rats, thymaline restored adequate blood coagulation responses to histamine.

    In plain wordsIn rats without a thymus, thymaline restored adequate blood clotting responses to histamine.

    Peptide
    Thymalin
    Outcome
    Not applicableBlood coagulation response to histamine
    Study

    ratn: not reported in source

    thymectomized rats
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but also recovers adequate responses of the blood coagulation and fibrinolysis systems to histamine administration
    1 context sentence
    Summary · context
    It was discovered in experiments on thymectomized rats that the animals developed hypercoagulation due to the shortening of prothrombinase formation time and to the inhibition of total and Hageman-dependent euglobulin fibrinolysis 2-3 months after the operation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized rats, thymaline restored adequate fibrinolysis responses to histamine.

    In plain wordsIn rats without a thymus, thymaline restored adequate clot breakdown responses to histamine.

    Peptide
    Thymalin
    Outcome
    Not applicableFibrinolysis response to histamine
    Study

    ratn: not reported in source

    thymectomized rats
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but also recovers adequate responses of the blood coagulation and fibrinolysis systems to histamine administration
    1 context sentence
    Summary · context
    It was discovered in experiments on thymectomized rats that the animals developed hypercoagulation due to the shortening of prothrombinase formation time and to the inhibition of total and Hageman-dependent euglobulin fibrinolysis 2-3 months after the operation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized rats, thymaline contributed to survival after histamine administration.

    In plain wordsIn rats without a thymus, thymaline helped preserve survival after histamine administration.

    Peptide
    Thymalin
    Outcome
    IncreaseSurvival after histamine
    Study

    ratn: not reported in source

    thymectomized rats
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but also recovers adequate responses of the blood coagulation and fibrinolysis systems to histamine administration, thereby contributing to the life preservation of the experimental animals.
    1 context sentence
    Summary · context
    It was discovered in experiments on thymectomized rats that the animals developed hypercoagulation due to the shortening of prothrombinase formation time and to the inhibition of total and Hageman-dependent euglobulin fibrinolysis 2-3 months after the operation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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