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Study · Animal study (in vivo) · rat · 1982

3 results

[Selective inhibition of microcirculation in tumor tissue by manipulated blood pressure reduction].

von Ardenne M, Reitnauer PG

Archiv fur Geschwulstforschung1 Jan 1982

PMID7149910 (opens in a new tab)PepBankPUB-07149910
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DS-carcinosarcoma, NAD reduced blood pressure to 50% of its initial value.

    In plain wordsIn rats with tumors, NAD reduced blood pressure to 50% of its initial value.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseBlood pressure reduction
    Study

    ratn: not reported in source

    DS-carcinosarcoma
    Comparator
    initial blood pressure
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Measurements

    Blood pressure
    50 % of initial value
    NAD exposure

    Source sentences

    Summary
    It was shown on the DS-carcinosarcoma of rat that NAD-induced blood pressure reduction to 50% of the initial value is followed by a selective compression ischemia in the tumor tissue.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DS-carcinosarcoma, NAD-induced blood pressure reduction was followed by selective compression ischemia in tumor tissue.

    In plain wordsIn rats with tumors, NAD-induced blood pressure reduction was followed by selective loss of tumor blood supply.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseTumor compression ischemia
    Study

    ratn: not reported in source

    DS-carcinosarcoma
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    It was shown on the DS-carcinosarcoma of rat that NAD-induced blood pressure reduction to 50% of the initial value is followed by a selective compression ischemia in the tumor tissue.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DS-carcinosarcoma, tumor microcirculation was almost completely inhibited during a period prolonged by NAD infusion.

    In plain wordsIn rats with tumors, NAD infusion prolonged a period of almost complete inhibition of tumor blood circulation.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseTumor microcirculation
    Study

    ratn: not reported in source

    DS-carcinosarcoma
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated · infusion · at least 10 minAs given in this study (rat).

    Source sentences

    Summary
    In this period that can be prolonged to at least 10 min by infusion of NAD the microcirculation in the tumor tissue is almost completely inhibited.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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