The nature of the changes in liver mitochondrial function induced by glucagon treatment of rats. The effects of intramitochondrial volume, aging and benzyl alcohol.

Armston AE, Halestrap AP, Scott RD

Biochimica et biophysica acta1 Sept 1982Cited by 49 (Europe PMC)

PMID7126557DOI10.1016/0005-2728(82)90185-2PepBankPUB-07126557

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, glucagon stimulated liver mitochondrial respiration, pyruvate metabolism and citrulline synthesis, with effects reversible by aging or benzyl alcohol.
In plain wordsIn rats, glucagon stimulated liver mitochondrial respiration, pyruvate metabolism and citrulline synthesis compared with control mitochondria.
Peptide
Glucagon
Outcome
IncreaseMitochondrial respiration, pyruvate metabolism and citrulline synthesis
Study
ratn: not reported in source
Liver mitochondria after glucagon treatment
Comparator
Control rats
Outcome group
Mitochondrial function · Liver
Studied dose
Dose not stated
Source sentences
Summary
(2) The stimulatory effects of glucagon on mitochondrial respiration, pyruvate metabolism and citrulline synthesis could be mimicked by hypo-osmotic treatment of control mitochondria and reversed by calcium-induced aging of mitochondria or by treatment with 20 mM benzyl alcohol.
1 context sentence(design, population, supporting numbers)
Summary · context
(1) The effects of changes in the intramitochondrial volume, benzyl alcohol treatment and calcium-induced mitochondrial aging on the behaviour of liver mitochondria from control and glucagon-treated rats are reported.
Report a problemFND-0712655701
02AnimalAnimal study (in vivo)Mechanism
In rats, liver mitochondria after glucagon treatment were less susceptible to calcium damage than control mitochondria.
In plain wordsIn rats, liver mitochondria after glucagon treatment were less susceptible to calcium damage than control mitochondria.
Peptide
Glucagon
Outcome
DecreaseSusceptibility to calcium damage
Study
ratn: not reported in source
Liver mitochondria after glucagon treatment
Comparator
Control rats
Outcome group
Mitochondrial function · Liver
Studied dose
Dose not stated
Source sentences
Summary
(3) Liver mitochondria from glucagon and adrenaline-treated rats were shown to be less susceptible to damage by exposure to calcium than control mitochondria and frequently showed slightly (15%) elevated intramitochondrial volumes.
1 context sentence(design, population, supporting numbers)
Summary · context
(1) The effects of changes in the intramitochondrial volume, benzyl alcohol treatment and calcium-induced mitochondrial aging on the behaviour of liver mitochondria from control and glucagon-treated rats are reported.
Report a problemFND-0712655702
03AnimalAnimal study (in vivo)Mechanism
In rats, liver mitochondria after glucagon treatment frequently showed intramitochondrial volumes elevated by 15% compared with controls.
In plain wordsIn rats, liver mitochondria after glucagon treatment frequently had volumes 15% greater than control mitochondria.
Peptide
Glucagon
Outcome
IncreaseIntramitochondrial volume
Study
ratn: not reported in source
Liver mitochondria after glucagon treatment
Comparator
Control rats
Outcome group
Mitochondrial function · Liver
Studied dose
Dose not stated
Measurements
Intramitochondrial volume elevation
15%
frequently observed
Source sentences
Summary
(3) Liver mitochondria from glucagon and adrenaline-treated rats were shown to be less susceptible to damage by exposure to calcium than control mitochondria and frequently showed slightly (15%) elevated intramitochondrial volumes.
1 context sentence(design, population, supporting numbers)
Summary · context
(1) The effects of changes in the intramitochondrial volume, benzyl alcohol treatment and calcium-induced mitochondrial aging on the behaviour of liver mitochondria from control and glucagon-treated rats are reported.
Report a problemFND-0712655703
04AnimalAnimal study (in vivo)Mechanism
In rats, mitochondria after glucagon treatment leaked fewer adenine nucleotides than control mitochondria.
In plain wordsIn rats, mitochondria after glucagon treatment leaked fewer adenine nucleotides than control mitochondria.
Peptide
Glucagon
Outcome
DecreaseAdenine nucleotide leakage
Study
ratn: not reported in source
Liver mitochondria after glucagon treatment
Comparator
Control rats
Outcome group
Mitochondrial function · Liver
Studied dose
Dose not stated
Source sentences
Summary
(5) Glucagon-treated mitochondria were less leaky to adenine nucleotides than control mitochondria.
1 context sentence(design, population, supporting numbers)
Summary · context
(1) The effects of changes in the intramitochondrial volume, benzyl alcohol treatment and calcium-induced mitochondrial aging on the behaviour of liver mitochondria from control and glucagon-treated rats are reported.
Report a problemFND-0712655704

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

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