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Study · Non-randomized trial · 1982

2 results

Effects of free fatty acids, insulin, glucagon and adrenaline on ketone body production in humans.

Miles JM, Haymond MW, Gerich JE

Ciba Foundation symposium1 Jan 1982Cited by 16 (Europe PMC)

PMID7042239 (opens in a new tab)DOI10.1002/9780470720691.ch11 (opens in a new tab)PepBankPUB-07042239
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In normal subjects under a hormone clamp and fatty-acid infusion, hyperglucagonaemia did not further increase ketogenesis.

    In plain wordsIn normal subjects under a hormone clamp and fatty-acid infusion, increased glucagon did not further raise ketone production.

    Peptide
    Glucagon
    Outcome
    No significant changeKetone body production
    Study

    n: not reported in source

    Comparator
    Basal glucagon under the hormone clamp
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hyperglucagonaemia did not further increase ketogenesis.
    1 context sentence
    Summary · context
    In normal human subjects, when plasma insulin, glucagon and growth hormone were 'clamped' at basal concentrations (by infusion of somatostatin plus replacement infusion of these hormones)
  2. 02HumanNon-randomized trialActivity measurement

    In normal subjects with insulin deficiency and fatty-acid infusion, hyperglucagonaemia increased ketogenesis by 2-3 fold the control increment.

    In plain wordsIn normal subjects with insulin deficiency and fatty-acid infusion, increased glucagon raised ketone production by 2-3 fold the control increment.

    Peptide
    Glucagon
    Outcome
    IncreaseKetone body production
    Study

    n: not reported in source

    Comparator
    Control studies during insulin and glucagon deficiency
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Ketogenesis increment
    2 to 3 fold
    control increment

    Source sentences

    Summary
    In these conditions hyperglucagonaemia increased ketogenesis by 2-3 fold the increment seen in control studies.
    1 context sentence
    Summary · context
    In conditions of combined insulin and glucagon deficiency (by infusion of somatostatin without insulin and glucagon)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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