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Study · Ex vivo tissue · rat · 1981

2 results

Thymosin stimulates secretion of luteinizing hormone-releasing factor.

Rebar RW, Miyake A, Low TL, Goldstein AL

Science (New York, N.Y.)1 Nov 1981Cited by 151 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In superfused medial basal hypothalami from female rats, thymosin alpha‑1 did not stimulate secretion of luteinizing hormone-releasing factor, unlike thymosin fraction 5 and thymosin beta 4.

    In plain wordsIn rat tissue in lab tests, thymosin alpha‑1 did not trigger release of a reproductive hormone signal, unlike thymosin beta 4.

    Outcome
    No significant changeLuteinizing hormone-releasing factor secretion
    Study

    ratn: not reported in source

    Superfused medial basal hypothalami from random cycling female rats
    Comparator
    Thymosin fraction 5 and thymosin beta 4
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Partially purified thymosin fraction 5 and one of its synthetic peptide components, thymosin beta 4, but not thymosin alpha 1, stimulated secretion of luteinizing hormone--releasing factor from superfused medial basal hypothalami from random cycling female rats.
  2. 02LabEx vivo tissueActivity measurement

    In superfused rat hypothalami, thymosin beta‑4 stimulated secretion of luteinizing hormone-releasing factor.

    In plain wordsIn rat brain tissue in the lab, thymosin beta‑4 raised release of luteinizing hormone-releasing factor.

    Outcome
    IncreaseLuteinizing hormone-releasing factor secretion
    Study

    ratn: not reported in source

    Superfused medial basal hypothalami from random cycling female rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Partially purified thymosin fraction 5 and one of its synthetic peptide components, thymosin beta 4, but not thymosin alpha 1, stimulated secretion of luteinizing hormone--releasing factor from superfused medial basal hypothalami from random cycling female rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    12 Oct 2026, 18:17 UTC

    Study data updated · source update from Europe PMC

  2. Version 3

    10 Oct 2026, 08:55 UTC

    Study results updated

  3. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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