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Study · Non-randomized trial · n = 3 · 1981

3 results

A prospective study of the antisecretory and therapeutic effects of cimetidine and glucagon in human acute pancreatitis.

Regan PT, Malagelada JR, Go VL, Wolf AM, DiMagno EP

Mayo Clinic proceedings1 Aug 1981Cited by 19 (Europe PMC)

PMID7022037 (opens in a new tab)PepBankPUB-07022037
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In patients with acute alcoholic pancreatitis, glucagon alone decreased gastric acid secretion.

    In plain wordsIn patients with acute alcoholic pancreatitis, glucagon alone decreased stomach acid secretion.

    Peptide
    Glucagon
    Outcome
    DecreaseGastric acid secretion
    Study

    n = 3

    Outcome group
    Gastrointestinal Secretion · Gastrointestinal
    Studied dose
    5 microgram/kg per hour · intravenousAs given in this study (human).

    Source sentences

    Summary
    In three subjects with acute alcoholic pancreatitis, gastric acid secretion was increased above normal and was decreased by glucagon and cimetidine used alone and in combination.
    1 context sentence
    Summary · context
    Thus, we compared the effects of nasogastric suction, intravenous glucagon (5 microgram/kg per hour), and cimetidine (2 mg/kg per hour) on the output of acid and pancreatic enzymes and the clinical course of human acute pancreatitis.
  2. 02HumanNon-randomized trialActivity measurement

    In two patients with acute pancreatitis, glucagon alone reduced duodenal trypsin output.

    In plain wordsIn two patients with acute pancreatitis, glucagon alone reduced trypsin output into the intestine.

    Peptide
    Glucagon
    Outcome
    DecreaseDuodenal trypsin output
    Study

    n = 2

    Outcome group
    Gastrointestinal Secretion · Gastrointestinal
    Studied dose
    5 microgram/kg per hour · intravenousAs given in this study (human).

    Source sentences

    Summary
    In two of the three patients, duodenal output of trypsin and lipase was normal or increased and was reduced by glucagon and cimetidine given alone or in combination.
    1 context sentence
    Summary · context
    Thus, we compared the effects of nasogastric suction, intravenous glucagon (5 microgram/kg per hour), and cimetidine (2 mg/kg per hour) on the output of acid and pancreatic enzymes and the clinical course of human acute pancreatitis.
  3. 03HumanNon-randomized trialActivity measurement

    In two patients with acute pancreatitis, glucagon alone reduced duodenal lipase output.

    In plain wordsIn two patients with acute pancreatitis, glucagon alone reduced lipase output into the intestine.

    Peptide
    Glucagon
    Outcome
    DecreaseDuodenal lipase output
    Study

    n = 2

    Outcome group
    Gastrointestinal Secretion · Gastrointestinal
    Studied dose
    5 microgram/kg per hour · intravenousAs given in this study (human).

    Source sentences

    Summary
    In two of the three patients, duodenal output of trypsin and lipase was normal or increased and was reduced by glucagon and cimetidine given alone or in combination.
    1 context sentence
    Summary · context
    Thus, we compared the effects of nasogastric suction, intravenous glucagon (5 microgram/kg per hour), and cimetidine (2 mg/kg per hour) on the output of acid and pancreatic enzymes and the clinical course of human acute pancreatitis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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