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Study · Randomized controlled trial · n = 22 · 1980

3 results

A randomized double-blind trial of glucagon in treatment of first attack of severe acute pancreatitis without associated biliary disease.

Kronborg O, Bülow S, Joergensen PM, Svendsen LB

The American journal of gastroenterology1 May 1980Cited by 15 (Europe PMC)

PMID6998284 (opens in a new tab)PepBankPUB-06998284
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialSafety outcome

    In severe acute pancreatitis, severe complications occurred in five of 10 glucagon recipients versus eight of 12 placebo recipients.

    In plain wordsIn severe acute pancreatitis, complications occurred in five of 10 glucagon recipients versus eight of 12 placebo recipients.

    Peptide
    Glucagon
    Outcome
    DecreaseSevere complications
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Adverse events · Gastrointestinal
    Studied dose
    1 mg bolus followed by 6 mg/24 hr · bolus injection followed by infusion · three daysAs given in this study (human).

    Measurements

    Severe complications
    5 patients
    glucagon
    Severe complications
    8 patients
    placebo

    Source sentences

    Summary
    Severe complications developed in five of the 10 patients receiving glucagon and in eight of the 12 given a placebo.
    2 context sentences
    Summary · context
    The effects of glucagon versus placebo were evaluated in a double-blind trial including only patients with a first attack of severe acute pancreatitis not associated with biliary disease.
    Summary · context
    An initial dose of 1 mg. glucagon was given as a bolus injection followed by infusion of 6 mg. in 1,500 ml. saline/24 hr. for three days.
  2. 02HumanRandomized controlled trialSafety outcome

    In severe acute pancreatitis, three of 10 glucagon recipients and five of 12 placebo recipients died from severe complications.

    In plain wordsIn severe acute pancreatitis, three of 10 glucagon recipients and five of 12 placebo recipients died from complications.

    Peptide
    Glucagon
    Outcome
    DecreaseDeaths from severe complications
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Mortality · Whole body
    Studied dose
    1 mg bolus followed by 6 mg/24 hr · bolus injection followed by infusion · three daysAs given in this study (human).

    Measurements

    Deaths
    3 patients
    glucagon
    Deaths
    5 patients
    placebo

    Source sentences

    Summary
    Three of the 10 (glucagon) and five of the 12 (placebo) died from these complications.
    2 context sentences
    Summary · context
    The effects of glucagon versus placebo were evaluated in a double-blind trial including only patients with a first attack of severe acute pancreatitis not associated with biliary disease.
    Summary · context
    An initial dose of 1 mg. glucagon was given as a bolus injection followed by infusion of 6 mg. in 1,500 ml. saline/24 hr. for three days.
  3. 03HumanRandomized controlled trialSafety outcome

    Among patients with hemorrhagic pancreatitis, three of five glucagon recipients died versus four of six placebo recipients.

    In plain wordsWith hemorrhagic pancreatitis, three of five glucagon recipients died versus four of six placebo recipients.

    Peptide
    Glucagon
    Outcome
    DecreaseMortality with hemorrhagic pancreatitis
    Study

    n = 11

    Comparator
    Placebo
    Outcome group
    Mortality · Whole body
    Studied dose
    1 mg bolus followed by 6 mg/24 hr · bolus injection followed by infusion · three daysAs given in this study (human).

    Measurements

    Deaths
    3 patients
    glucagon
    Deaths
    4 patients
    placebo

    Source sentences

    Summary
    Three of the five with hemorrhagic pancreatitis in the glucagon group and four of the six in the placebo group died.
    2 context sentences
    Summary · context
    The effects of glucagon versus placebo were evaluated in a double-blind trial including only patients with a first attack of severe acute pancreatitis not associated with biliary disease.
    Summary · context
    An initial dose of 1 mg. glucagon was given as a bolus injection followed by infusion of 6 mg. in 1,500 ml. saline/24 hr. for three days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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