Skip to content

Study · Animal study (in vivo) · mouse · 1981

4 results

Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations.

Low TL, Hu SK, Goldstein AL

Proceedings of the National Academy of Sciences of the United States of America1 Feb 1981Cited by 198 (Europe PMC)

PMID6940133 (opens in a new tab)PMCIDPMC319967 (opens in a new tab)DOI10.1073/pnas.78.2.1162 (opens in a new tab)PepBankPUB-06940133
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    Thymosin beta‑4 induced expression of terminal deoxynucleotidyl transferase in transferase-negative murine thymocytes in vivo.

    In plain wordsIn mice, thymosin beta‑4 switched on terminal deoxynucleotidyl transferase in thymus immune cells that had none.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTerminal deoxynucleotidyl transferase expression in thymocytes in vivo
    Study

    mousen: not reported in source

    transferase-negative murine thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    induces expression of terminal deoxynucleotidyl transferase (DNA nucleotidylexotransferase, EC 2.7.7.31) in transferase-negative murine thymocytes in vivo
  2. 02LabIn vitro (cells)Activity measurement

    Thymosin beta‑4 induced expression of terminal deoxynucleotidyl transferase in transferase-negative murine thymocytes in vitro.

    In plain wordsIn mouse cells, thymosin beta‑4 switched on terminal deoxynucleotidyl transferase in thymus immune cells that had none.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTerminal deoxynucleotidyl transferase expression in thymocytes in vitro
    Study

    mousen: not reported in source

    transferase-negative murine thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    induces expression of terminal deoxynucleotidyl transferase (DNA nucleotidylexotransferase, EC 2.7.7.31) in transferase-negative murine thymocytes in vivo and in citro.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Other

    Bovine thymosin beta‑4 has 43 amino acid residues, a molecular weight of 4982 and an isoelectric point of 5.1.

    In plain wordsIn lab analysis, calf thymosin beta‑4 had 43 amino acids, a weight of 4982 and an isoelectric point of 5.1.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableSize and isoelectric point of bovine thymosin beta 4
    Study

    n: not reported in source

    Outcome group
    Peptide structure and chemistry · Pharmacology

    Measurements

    amino acid residues
    43
    bovine thymosin beta 4
    molecular weight
    4982
    bovine thymosin beta 4
    isoelectric point
    5.1
    bovine thymosin beta 4

    Source sentences

    Summary
    Thymosin beta 4 is composed of 43 amino acid residues and has a molecular weight of 4982 and an isoelectric point of 5.1.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Other

    The NH2 terminus of thymosin beta‑4 is blocked by an acetyl group.

    In plain wordsIn lab analysis, the start of thymosin beta‑4 is blocked by an acetyl group.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableNH2 terminus of thymosin beta 4
    Study

    n: not reported in source

    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    The NH2 terminus of the peptide is blocked by an acetyl group.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.