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Study · Animal study (in vivo) · rat · 1981

6 results

[Development of an experimental tuberculous process in the presence of immune deficiency and immunostimulation].

Shcherbakova NM, Aleksandrova AE, Morozov VG, Podosinnikov IS, Khavinson VKh

Biulleten' eksperimental'noi biologii i meditsiny1 Sept 1981

PMID6895337 (opens in a new tab)PepBankPUB-06895337
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized rats infected 9 months after thymectomy, lung damage was less severe with thymalin than without treatment.

    In plain wordsIn rats infected 9 months after thymus removal, lung damage was less severe with thymalin than without treatment.

    Peptide
    Thymalin
    Outcome
    DecreaseLung damage
    Study

    ratn: not reported in source

    thymectomized rats with experimental tuberculosis
    Comparator
    untreated thymectomized rats infected 9 months after thymectomy
    Outcome group
    Infection and antimicrobial activity · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was established that the lungs of thymectomized rats infected 9 months after the thymectomy were damaged more severely as compared with control or thymalin-treated animals.
    2 context sentences
    Summary · context
    The effects were studied of the degree of immunodeficiency produced by thymectomy of one-month-old rats on the course of experimental tuberculosis induced 3, 6 and 9 months after thymectomy.
    Summary · context
    Subject to study was also the effect of immunodeficiency correction with thymalin on the tuberculous process.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized rats, thymalin treatment was associated with lower absolute numbers of medium-sized peripheral blood lymphocytes.

    In plain wordsIn rats without a thymus, thymalin treatment was linked to fewer medium-sized lymphocytes in blood.

    Peptide
    Thymalin
    Outcome
    DecreaseMedium-sized peripheral blood lymphocytes
    Study

    ratn: not reported in source

    thymectomized rats with experimental tuberculosis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In thymectomized rats treated with thymalin, the absolute content of medium-sized and big lymphocytes in peripheral blood was found to be lower, the content of small lymphocytes being unchanged throughout all observation periods.
    2 context sentences
    Summary · context
    The effects were studied of the degree of immunodeficiency produced by thymectomy of one-month-old rats on the course of experimental tuberculosis induced 3, 6 and 9 months after thymectomy.
    Summary · context
    Subject to study was also the effect of immunodeficiency correction with thymalin on the tuberculous process.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized rats, thymalin treatment was associated with lower absolute numbers of big peripheral blood lymphocytes.

    In plain wordsIn rats without a thymus, thymalin treatment was linked to fewer big lymphocytes in blood.

    Peptide
    Thymalin
    Outcome
    DecreaseBig peripheral blood lymphocytes
    Study

    ratn: not reported in source

    thymectomized rats with experimental tuberculosis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In thymectomized rats treated with thymalin, the absolute content of medium-sized and big lymphocytes in peripheral blood was found to be lower, the content of small lymphocytes being unchanged throughout all observation periods.
    2 context sentences
    Summary · context
    The effects were studied of the degree of immunodeficiency produced by thymectomy of one-month-old rats on the course of experimental tuberculosis induced 3, 6 and 9 months after thymectomy.
    Summary · context
    Subject to study was also the effect of immunodeficiency correction with thymalin on the tuberculous process.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized rats treated with thymalin, small lymphocyte content remained unchanged throughout observation.

    In plain wordsIn rats without a thymus treated with thymalin, small lymphocyte numbers remained unchanged during observation.

    Peptide
    Thymalin
    Outcome
    No significant changeSmall peripheral blood lymphocytes
    Study

    ratn: not reported in source

    thymectomized rats with experimental tuberculosis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In thymectomized rats treated with thymalin, the absolute content of medium-sized and big lymphocytes in peripheral blood was found to be lower, the content of small lymphocytes being unchanged throughout all observation periods.
    2 context sentences
    Summary · context
    The effects were studied of the degree of immunodeficiency produced by thymectomy of one-month-old rats on the course of experimental tuberculosis induced 3, 6 and 9 months after thymectomy.
    Summary · context
    Subject to study was also the effect of immunodeficiency correction with thymalin on the tuberculous process.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats treated with thymalin, spontaneous migration activity followed the control time course, unlike untreated thymectomized rats.

    In plain wordsIn rats, thymalin treatment produced spontaneous cell migration patterns that matched controls, unlike untreated rats without a thymus.

    Peptide
    Thymalin
    Outcome
    Not applicableSpontaneous migration activity time course
    Study

    ratn: not reported in source

    thymectomized rats with experimental tuberculosis
    Comparator
    controls and untreated thymectomized rats
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The time course of migration activity (spontaneous and in response to PPD) in rats treated with thymalin corresponded with the time course in controls in contrast to thymectomized rats which did not receive the treatment.
    2 context sentences
    Summary · context
    The effects were studied of the degree of immunodeficiency produced by thymectomy of one-month-old rats on the course of experimental tuberculosis induced 3, 6 and 9 months after thymectomy.
    Summary · context
    Subject to study was also the effect of immunodeficiency correction with thymalin on the tuberculous process.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats treated with thymalin, migration activity in response to PPD followed the control time course, unlike untreated thymectomized rats.

    In plain wordsIn rats, thymalin treatment produced PPD-induced cell migration patterns that matched controls, unlike untreated rats without a thymus.

    Peptide
    Thymalin
    Outcome
    Not applicablePPD-induced migration activity time course
    Study

    ratn: not reported in source

    thymectomized rats with experimental tuberculosis
    Comparator
    controls and untreated thymectomized rats
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The time course of migration activity (spontaneous and in response to PPD) in rats treated with thymalin corresponded with the time course in controls in contrast to thymectomized rats which did not receive the treatment.
    2 context sentences
    Summary · context
    The effects were studied of the degree of immunodeficiency produced by thymectomy of one-month-old rats on the course of experimental tuberculosis induced 3, 6 and 9 months after thymectomy.
    Summary · context
    Subject to study was also the effect of immunodeficiency correction with thymalin on the tuberculous process.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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