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Study · Case report or series · n = 1 · 1983

10 results

Studies of the efficacy and potential hazards of methylene blue therapy in aniline-induced methaemoglobinaemia.

Harvey JW, Keitt AS

British journal of haematology1 May 1983Cited by 62 (Europe PMC)

PMID6849836 (opens in a new tab)DOI10.1111/j.1365-2141.1983.tb02064.x (opens in a new tab)PepBankPUB-06849836
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 2 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In a patient with aniline-induced methaemoglobinaemia, two methylene blue injections did not rapidly eliminate cyanosis.

    In plain wordsIn a patient with aniline poisoning, methylene blue did not rapidly eliminate cyanosis.

    Peptide
    Methylene blue
    Outcome
    Direction not reportedPersistent cyanosis
    Study

    n = 1

    Outcome group
    Blood oxygenation and oxygen transport · Whole body
    Studied dose
    Dose not stated · injectionAs given in this study (human).

    Source sentences

    Summary
    Studies were prompted by a case of aniline-induced methaemoglobinaemia in which two injections of methylene blue did not rapidly eliminate cyanosis and were followed by severe, delayed haemolysis.
  2. 02HumanCase report or seriesSafety outcome

    In a patient with aniline-induced methaemoglobinaemia, severe delayed haemolysis followed two methylene blue injections.

    In plain wordsIn a patient with aniline poisoning, severe delayed red blood cell destruction followed methylene blue injections.

    Peptide
    Methylene blue
    Outcome
    Direction not reportedDelayed haemolysis
    Study

    n = 1

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · injectionAs given in this study (human).

    Source sentences

    Summary
    Studies were prompted by a case of aniline-induced methaemoglobinaemia in which two injections of methylene blue did not rapidly eliminate cyanosis and were followed by severe, delayed haemolysis.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In cats exposed to aniline, methylene blue increased Heinz body size as an indicator of oxidative haemoglobin denaturation.

    In plain wordsIn cats exposed to aniline, methylene blue increased Heinz body size compared with aniline exposure alone.

    Peptide
    Methylene blue
    Outcome
    IncreaseHeinz body size
    Study

    catsn: not reported in source

    aniline exposure
    Comparator
    Aniline exposure
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Methylene blue potentiated the oxidative denaturation of haemoglobin by aniline as judged by the size and number of Heinz bodies and their turbidity in haemolysate.
    1 context sentence
    Summary · context
    Interactions between aniline and methylene blue were studied in cats which, although showing important differences from man in their haemoglobin and splenic vasculature, represent a useful model.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In cats exposed to aniline, methylene blue aggravated and prolonged the fall in erythrocyte reduced glutathione content.

    In plain wordsIn cats exposed to aniline, methylene blue worsened and prolonged the reduction in red blood cell glutathione compared with aniline exposure.

    Peptide
    Methylene blue
    Outcome
    DecreaseErythrocyte reduced glutathione content
    Study

    catsn: not reported in source

    aniline exposure
    Comparator
    Aniline exposure
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It also aggravated and prolonged the fall in erythrocyte reduced glutathione content which occurred at a time of maximum Heinz body production.
    1 context sentence
    Summary · context
    Interactions between aniline and methylene blue were studied in cats which, although showing important differences from man in their haemoglobin and splenic vasculature, represent a useful model.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In cats after aniline exposure, methylene blue in judicious dosage reduced methaemoglobin content.

    In plain wordsIn cats after aniline exposure, methylene blue in judicious dosage reduced methaemoglobin content.

    Peptide
    Methylene blue
    Outcome
    DecreaseMethaemoglobin content
    Study

    catsn: not reported in source

    aniline exposure
    Outcome group
    Blood oxygenation and oxygen transport · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    While methylene blue in judicious dosage will reduce the content of methaemoglobin after aniline exposure, it may not eliminate visible cyanosis.
    1 context sentence
    Summary · context
    Interactions between aniline and methylene blue were studied in cats which, although showing important differences from man in their haemoglobin and splenic vasculature, represent a useful model.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In cats after aniline exposure, repeated methylene blue injections can markedly aggravate subsequent haemolysis.

    In plain wordsIn cats after aniline exposure, repeated methylene blue injections can markedly worsen subsequent red blood cell destruction.

    Peptide
    Methylene blue
    Outcome
    IncreaseHaemolysis after repeated injections
    Study

    catsn: not reported in source

    aniline exposure
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · injectionAs given in this study (cats).

    Source sentences

    Summary
    Repeated injections of methylene blue can markedly aggravate subsequent haemolysis without further lowering methaemoglobin content.
    1 context sentence
    Summary · context
    Interactions between aniline and methylene blue were studied in cats which, although showing important differences from man in their haemoglobin and splenic vasculature, represent a useful model.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In cats after aniline exposure, repeated methylene blue injections did not further lower methaemoglobin content.

    In plain wordsIn cats after aniline exposure, repeated methylene blue injections did not further lower methaemoglobin content.

    Peptide
    Methylene blue
    Outcome
    No significant changeFurther methaemoglobin lowering after repeated injections
    Study

    catsn: not reported in source

    aniline exposure
    Outcome group
    Blood oxygenation and oxygen transport · Whole body
    Studied dose
    Dose not stated · injectionAs given in this study (cats).

    Source sentences

    Summary
    Repeated injections of methylene blue can markedly aggravate subsequent haemolysis without further lowering methaemoglobin content.
    1 context sentence
    Summary · context
    Interactions between aniline and methylene blue were studied in cats which, although showing important differences from man in their haemoglobin and splenic vasculature, represent a useful model.
  8. 08AnimalAnimal study (in vivo)Safety outcome

    In cats exposed to aniline, methylene blue increased Heinz body number as an indicator of oxidative haemoglobin denaturation.

    In plain wordsIn cats exposed to aniline, methylene blue increased Heinz body number compared with aniline exposure alone.

    Peptide
    Methylene blue
    Outcome
    IncreaseHeinz body number
    Study

    catsn: not reported in source

    aniline exposure
    Comparator
    aniline exposure alone
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Methylene blue potentiated the oxidative denaturation of haemoglobin by aniline as judged by the size and number of Heinz bodies and their turbidity in haemolysate.
    1 context sentence
    Summary · context
    Interactions between aniline and methylene blue were studied in cats which, although showing important differences from man in their haemoglobin and splenic vasculature, represent a useful model.
  9. 09AnimalAnimal study (in vivo)Safety outcome

    In cats exposed to aniline, methylene blue increased Heinz body turbidity in haemolysate as an indicator of oxidative haemoglobin denaturation.

    In plain wordsIn cats exposed to aniline, methylene blue increased Heinz body turbidity in haemolysate compared with aniline exposure alone.

    Peptide
    Methylene blue
    Outcome
    IncreaseHeinz body turbidity in haemolysate
    Study

    catsn: not reported in source

    aniline exposure
    Comparator
    aniline exposure alone
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Methylene blue potentiated the oxidative denaturation of haemoglobin by aniline as judged by the size and number of Heinz bodies and their turbidity in haemolysate.
    1 context sentence
    Summary · context
    Interactions between aniline and methylene blue were studied in cats which, although showing important differences from man in their haemoglobin and splenic vasculature, represent a useful model.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In cats after aniline exposure, methylene blue in judicious dosage may not eliminate visible cyanosis.

    In plain wordsIn cats after aniline exposure, methylene blue in judicious dosage may not eliminate visible cyanosis.

    Peptide
    Methylene blue
    Outcome
    Direction not reportedVisible cyanosis
    Study

    catsn: not reported in source

    aniline exposure
    Outcome group
    Blood oxygenation and oxygen transport · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    While methylene blue in judicious dosage will reduce the content of methaemoglobin after aniline exposure, it may not eliminate visible cyanosis.
    1 context sentence
    Summary · context
    Interactions between aniline and methylene blue were studied in cats which, although showing important differences from man in their haemoglobin and splenic vasculature, represent a useful model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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