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Study · Other design · 1983

4 results

Solid-phase synthesis of thymosin beta 4: chemical and biological characterization of the synthetic peptide.

Low TL, Wang SS, Goldstein AL

Biochemistry1 Feb 1983Cited by 12 (Europe PMC)

PMID6838821 (opens in a new tab)DOI10.1021/bi00273a004 (opens in a new tab)PepBankPUB-06838821
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabOther designActivity measurement

    Synthetic thymosin beta‑4 was as active as natural thymosin beta‑4 in a terminal deoxynucleotidyltransferase induction assay.

    In plain wordsIn a lab assay, lab-made thymosin beta‑4 was as active as natural thymosin beta‑4 at inducing terminal deoxynucleotidyltransferase.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTerminal deoxynucleotidyltransferase induction by synthetic thymosin beta 4
    Study

    n: not reported in source

    Comparator
    natural thymosin beta 4
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    synthetic thymosin beta 4 was found to be as active as the natural compound in a terminal deoxynucleotidyltransferase induction assay
  2. 02LabOther designActivity measurement

    Synthetic thymosin beta‑4 was as active as natural thymosin beta‑4 in a macrophage migration inhibition assay.

    In plain wordsIn a lab assay, lab-made thymosin beta‑4 was as active as natural thymosin beta‑4 at inhibiting macrophage migration.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableMacrophage migration inhibition by synthetic thymosin beta 4
    Study

    n: not reported in source

    Comparator
    natural thymosin beta 4
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    synthetic thymosin beta 4 was found to be as active as the natural compound in a terminal deoxynucleotidyltransferase induction assay and in a macrophage migration inhibition assay

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Other

    Solid-phase synthetic thymosin beta‑4 was homogeneous on paper electrophoresis, reversed-phase HPLC and isoelectric focusing.

    In plain wordsIn lab tests, the lab-made thymosin beta‑4 was pure by three separation methods.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicablePurity of synthetic thymosin beta 4
    Study

    n: not reported in source

    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    The synthetic product was found to be homogeneous on paper electrophoresis at pH 6.5, high-performance liquid chromatography on a reversed-phase column, and isoelectric focusing using polyacrylamide gels.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Other

    Synthetic thymosin beta‑4 was identical to natural thymosin beta‑4 by tryptic peptide mapping, amino acid analysis and gel isoelectric focusing.

    In plain wordsIn lab tests, lab-made thymosin beta‑4 matched natural thymosin beta‑4 in three tests.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableIdentity of synthetic with natural thymosin beta 4
    Study

    n: not reported in source

    Comparator
    natural thymosin beta 4
    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    The synthetic material was also shown to be identical with the natural thymosin beta 4 by tryptic peptide mapping, amino acid compositional analyses, and polyacrylamide gel isoelectric focusing.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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