The International Reference Preparation of Gonadorelin for Bioassay: a comparison with different preparations of synthetic luteinizing hormone releasing hormone using physicochemical methods of analysis, different bioassays and immunoassay.

Storring PL, Corran PH, Gaines Das RE, Calam DH

The Journal of endocrinology1 Oct 1982Cited by 1 (Europe PMC)

PMID6752326DOI10.1677/joe.0.0950095PepBankPUB-06752326

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Gonadorelin (GnRH, LHRH).

01LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other
By HPLC, the International Reference Preparation of Gonadorelin for Bioassay was about 88.3% (w/w) pure.
In plain wordsIn lab tests, the international reference sample of gonadorelin was about 88.3% pure by weight.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicablePurity of the reference preparation by HPLC
Study
n: not reported in source
Physicochemical analysis and bioassays of the International Reference Preparation
Outcome group
Product quality and purity · Pharmacology
Measurements
Purity
88.3 % (w/w)
IRP, HPLC
Source sentences
Summary
the latter preparation appeared to be 88.3% (w/w) pure, judged by HPLC
1 context sentence(design, population, supporting numbers)
Summary · context
The IRP was studied by four laboratories in four countries and compared, using physicochemical methods of analysis, various bioassay procedures and immunoassay, with preparations of synthetic luteinizing hormone releasing hormone (LH-RH) produced by different manufacturers.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0675232601
02LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other
Each ampoule of the International Reference Preparation was estimated to contain approximately 31 nmol LH-RH.
In plain wordsIn lab tests, each ampoule of the reference sample was estimated to hold about 31 nmol of LH-RH.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableLH-RH content per ampoule
Study
n: not reported in source
Physicochemical analysis and bioassays of the International Reference Preparation
Outcome group
Product quality and purity · Pharmacology
Measurements
LH-RH content per ampoule
≈ 31 nmol
IRP ampoule
Source sentences
Summary
The data from the collaborative study suggested that each ampoule of the IRP contains approximately 31 nmol LH-RH.
1 context sentence(design, population, supporting numbers)
Summary · context
The IRP was studied by four laboratories in four countries and compared, using physicochemical methods of analysis, various bioassay procedures and immunoassay, with preparations of synthetic luteinizing hormone releasing hormone (LH-RH) produced by different manufacturers.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0675232602
03LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other
The reference preparation behaved similarly to other LH-RH preparations in different bioassays, as far as this could be examined.
In plain wordsIn lab tests, the reference sample behaved like other LH-RH preparations in different bioassays, as far as this could be examined.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableSimilarity of bioassay behaviour to other LH-RH preparations
Study
n: not reported in source
Physicochemical analysis and bioassays of the International Reference Preparation
Outcome group
Product quality and purity · Pharmacology
Source sentences
Summary
since its behaviour was similar in different bioassays, so far as this could be examined, to that of the other preparations of LH-RH with which it was compared
1 context sentence(design, population, supporting numbers)
Summary · context
The IRP was studied by four laboratories in four countries and compared, using physicochemical methods of analysis, various bioassay procedures and immunoassay, with preparations of synthetic luteinizing hormone releasing hormone (LH-RH) produced by different manufacturers.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0675232603
04LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other
Biological activities of different LH-RH preparations, assessed against the reference preparation, appeared to correlate with their purity by physicochemical methods.
In plain wordsIn lab tests, the biological activity of different LH-RH samples appeared to match how pure they were.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableCorrelation of biological activity with purity
Study
n: not reported in source
Physicochemical analysis and bioassays of the International Reference Preparation
Outcome group
Product quality and purity · Pharmacology
Source sentences
Summary
the biological activities of different preparations of LH-RH, assessed in terms of the IRP, appeared to correlate with their degrees of purify assessed by physicochemical methods
1 context sentence(design, population, supporting numbers)
Summary · context
The IRP was studied by four laboratories in four countries and compared, using physicochemical methods of analysis, various bioassay procedures and immunoassay, with preparations of synthetic luteinizing hormone releasing hormone (LH-RH) produced by different manufacturers.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0675232604

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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