Inhibition of pituitary-testicular function with [D-Trp6] luteinizing hormone-releasing hormone in rhesus monkeys.

Sundaram K, Connell KG, Bardin CW, Samojlik E, Schally AV

Endocrinology1 Apr 1982Cited by 25 (Europe PMC)

PMID6460610DOI10.1210/endo-110-4-1308PepBankPUB-06460610

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys, twice-weekly triptorelin decreased LH responses to successive doses by 75%.
In plain wordsIn rhesus monkeys, repeated twice-weekly triptorelin reduced LH responses.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH response with twice-weekly dosing
Study
rhesus monkeyn = 4
Male rhesus monkeys
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 micrograms twice weekly · 12 weeksAs given in this study (rhesus monkey).
Measurements
LH response decrease
75%
twice-weekly dosing for 12 weeks
Source sentences
Summary
The administration of 500 micrograms [D-Trp6]LHRH twice weekly for 12 weeks led to a 75% decrease in the LH responses to successive doses of this peptide; testosterone responses in these animals were unchanged, however.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys.
Report a problemFND-0646061003
02AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys, testosterone responses remained unchanged during twice-weekly triptorelin treatment.
In plain wordsIn rhesus monkeys, twice-weekly triptorelin did not change testosterone responses.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeTestosterone response with twice-weekly dosing
Study
rhesus monkeyn = 4
Male rhesus monkeys
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 micrograms twice weekly · 12 weeksAs given in this study (rhesus monkey).
Source sentences
Summary
The administration of 500 micrograms [D-Trp6]LHRH twice weekly for 12 weeks led to a 75% decrease in the LH responses to successive doses of this peptide; testosterone responses in these animals were unchanged, however.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys.
Report a problemFND-0646061004
03AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys, sperm motility did not change during twice-weekly triptorelin treatment.
In plain wordsIn rhesus monkeys, twice-weekly triptorelin did not change sperm motility.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeSperm motility with twice-weekly dosing
Study
rhesus monkeyn = 4
Male rhesus monkeys
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 micrograms twice weekly · 12 weeksAs given in this study (rhesus monkey).
Source sentences
Summary
The lack of any change in the motility or sperm number in semen obtained by electroejaculation suggested that there was no effect on spermatogenesis during the twice weekly administration.
2 context sentences(design, population, supporting numbers)
Summary · context
The administration of 500 micrograms [D-Trp6]LHRH twice weekly for 12 weeks led to a 75% decrease in the LH responses to successive doses of this peptide; testosterone responses in these animals were unchanged, however.
Summary · context
The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys.
Report a problemFND-0646061005
04AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys, sperm number did not change during twice-weekly triptorelin treatment.
In plain wordsIn rhesus monkeys, twice-weekly triptorelin did not change sperm number.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeSperm number with twice-weekly dosing
Study
rhesus monkeyn = 4
Male rhesus monkeys
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 micrograms twice weekly · 12 weeksAs given in this study (rhesus monkey).
Source sentences
Summary
The lack of any change in the motility or sperm number in semen obtained by electroejaculation suggested that there was no effect on spermatogenesis during the twice weekly administration.
2 context sentences(design, population, supporting numbers)
Summary · context
The administration of 500 micrograms [D-Trp6]LHRH twice weekly for 12 weeks led to a 75% decrease in the LH responses to successive doses of this peptide; testosterone responses in these animals were unchanged, however.
Summary · context
The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys.
Report a problemFND-0646061006
05AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys, daily triptorelin dramatically reduced LH responses to the agonist in all four animals.
In plain wordsIn rhesus monkeys, daily triptorelin reduced LH responses in all four animals.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH response with daily dosing
Study
rhesus monkeyn = 4
Male rhesus monkeys
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 micrograms daily · 16 weeksAs given in this study (rhesus monkey).
Source sentences
Summary
This caused dramatic decreases in the LH responses to the agonist in all four animals.
2 context sentences(design, population, supporting numbers)
Summary · context
These animals were then treated with [D-Trp6]LHRH (500 micrograms daily) for 16 weeks.
Summary · context
The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys.
Report a problemFND-0646061007
06AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys receiving daily triptorelin, testosterone responses decreased in two animals and disappeared in two.
In plain wordsIn rhesus monkeys, daily triptorelin reduced testosterone responses in two animals and eliminated them in two.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseTestosterone response with daily dosing
Study
rhesus monkeyn = 4
Male rhesus monkeys
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 micrograms daily · 16 weeksAs given in this study (rhesus monkey).
Source sentences
Summary
The testosterone response was reduced in two and abolished in two animals.
2 context sentences(design, population, supporting numbers)
Summary · context
These animals were then treated with [D-Trp6]LHRH (500 micrograms daily) for 16 weeks.
Summary · context
The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys.
Report a problemFND-0646061008
07AnimalAnimal study (in vivo)Efficacy outcome
In two rhesus monkeys with abolished testosterone responses during daily triptorelin treatment, electroejaculatory responses also disappeared.
In plain wordsIn rhesus monkeys, the two animals with no testosterone response also lost their electrically stimulated ejaculation response.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseElectroejaculatory response
Study
rhesus monkeyn = 2
Male rhesus monkeys
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
500 micrograms daily · 16 weeksAs given in this study (rhesus monkey).
Source sentences
Summary
These latter two animals also lost their electroejaculatory response.
3 context sentences(design, population, supporting numbers)
Summary · context
The testosterone response was reduced in two and abolished in two animals.
Summary · context
These animals were then treated with [D-Trp6]LHRH (500 micrograms daily) for 16 weeks.
Summary · context
The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys.
Report a problemFND-0646061009
08AnimalAnimal study (in vivo)Efficacy outcome
In two rhesus monkeys recovering after daily triptorelin cessation, ejaculates contained no sperm, indicating transient azoospermia.
In plain wordsIn rhesus monkeys, two animals temporarily produced sperm-free ejaculates after daily triptorelin stopped.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseRecovery-period azoospermia
Study
rhesus monkeyn = 2
Male rhesus monkeys
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 micrograms daily · 16 weeksAs given in this study (rhesus monkey).
Source sentences
Summary
During the recovery period following the cessation of treatment, these two animals produced ejaculates with no sperm, indicating that a transient period of azoospermia was achieved.
2 context sentences(design, population, supporting numbers)
Summary · context
These animals were then treated with [D-Trp6]LHRH (500 micrograms daily) for 16 weeks.
Summary · context
The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys.
Report a problemFND-0646061010
09AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys, acute triptorelin produced dose-related increases in serum testosterone.
In plain wordsIn rhesus monkeys, acute triptorelin increased testosterone in a dose-related manner.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseAcute serum testosterone
Study
rhesus monkeyn: not reported in source
Male rhesus monkeys
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
5, 25, or 500 microgramsAs given in this study (rhesus monkey).
Source sentences
Summary
Acute administration of 5, 25, or 500 micrograms [D-Trp6]LHRH produced dose-related increases in serum testosterone and bioassayable LH levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys.
Report a problemFND-0646061001
10AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys, acute triptorelin produced dose-related increases in bioassayable LH.
In plain wordsIn rhesus monkeys, acute triptorelin increased biologically active LH in a dose-related manner.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseAcute bioassayable LH
Study
rhesus monkeyn: not reported in source
Male rhesus monkeys
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
5, 25, or 500 microgramsAs given in this study (rhesus monkey).
Source sentences
Summary
Acute administration of 5, 25, or 500 micrograms [D-Trp6]LHRH produced dose-related increases in serum testosterone and bioassayable LH levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys.
Report a problemFND-0646061002

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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