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Study · Animal study (in vivo) · rat · 1983

2 results

Histological and histochemical observations on the testis and epididymis of the albino rat treated with ACTH 1-39 and dexamethasone.

Pellegrini A, Ricciardi MP

International journal of tissue reactions1 Jan 1983Cited by 1 (Europe PMC)

PMID6305865 (opens in a new tab)PepBankPUB-06305865
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In adult male rats, small doses of ACTH1-39 produced the greatest testicular damage a few days after treatment stopped.

    In plain wordsIn rats, small ACTH1-39 doses produced the greatest testicular damage a few days after treatment stopped.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreaseTesticular morphological damage
    Study

    ratn: not reported in source

    Adult male albino rats
    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Morphological examination showed that the greatest damage in the testis was produced a few days after suspension of treatment by small doses of ACTH
    3 context sentences
    Title · context
    Histological and histochemical observations on the testis and epididymis of the albino rat treated with ACTH 1-39 and dexamethasone.
    Summary · context
    We analysed the modifications induced in the testis and epididymis of the adult male albino rat by drugs stimulating (ACTH) and inhibiting (dexamethasone) the steroidogenesis of the adrenal cortex.
    Summary · context
    After stopping treatment, observations were continued for several days in order to follow up the possible long-term effects of these drugs.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In adult male rats treated with ACTH1-39, the study reported no noteworthy histochemical modifications.

    In plain wordsIn rats treated with ACTH1-39, the study found no noteworthy histochemical changes.

    Peptide
    ACTH (corticotropin)
    Outcome
    No significant changeHistochemical modifications
    Study

    ratn: not reported in source

    Adult male albino rats
    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No noteworthy histochemical modifications were observed.
    3 context sentences
    Title · context
    Histological and histochemical observations on the testis and epididymis of the albino rat treated with ACTH 1-39 and dexamethasone.
    Summary · context
    We analysed the modifications induced in the testis and epididymis of the adult male albino rat by drugs stimulating (ACTH) and inhibiting (dexamethasone) the steroidogenesis of the adrenal cortex.
    Summary · context
    After stopping treatment, observations were continued for several days in order to follow up the possible long-term effects of these drugs.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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