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Study · Animal study (in vivo) · rat · 1982

2 results

Fate of human corticotrophin immediately after intravenous administration to the rat.

Ambler L, Bennett HP, Hudson AM, McMartin C

The Journal of endocrinology1 May 1982Cited by 8 (Europe PMC)

PMID6283006 (opens in a new tab)DOI10.1677/joe.0.0930287 (opens in a new tab)PepBankPUB-06283006
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, a major circulating 3-39 corticotrophin metabolite appeared within 5 min after intravenous human ACTH1-39.

    In plain wordsIn rats, a major breakdown product appeared in blood within 5 min after intravenous human ACTH1-39.

    Peptide
    ACTH (corticotropin)
    Outcome
    Not applicableCirculating 3-39 corticotrophin metabolite appearance
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Measurements

    Metabolite appearance time
    ≤ 5 min
    circulation

    Source sentences

    Summary
    Within 5 min of injection of single major metabolite, 3-39 corticotrophin, appears in the circulation.
    1 context sentence
    Summary · context
    The distribution and degradation of tritium-labelled human 1-39 corticotrophin have been studied after intravenous administration to the rat.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, intravenous human ACTH1-39 showed extensive degradation across muscle, skin, liver, kidney, and gut by 5 min.

    In plain wordsIn rats, human ACTH1-39 showed extensive breakdown across muscle, skin, liver, kidney, and gut by 5 min.

    Peptide
    ACTH (corticotropin)
    Outcome
    Not applicableDegradation across major tissues
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Measurements

    Observation time
    5 min
    major tissue degradation

    Source sentences

    Summary
    By 5 min, extensive degradation had occurred in all the major tissues in the body (muscle, skin, liver, kidney, gut).
    1 context sentence
    Summary · context
    The distribution and degradation of tritium-labelled human 1-39 corticotrophin have been studied after intravenous administration to the rat.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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