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Study · Non-randomized trial · n = 10 · 1981

3 results

Plasma cortisol following injection of 1-39 or 1-18 ACTH.

Danowski TS, Ohlsen P, Fisher ER, Mreiden TI, Dhawan R, Sunder JH

Journal of clinical pharmacology1 Feb 1981Cited by 1 (Europe PMC)

PMID6262387 (opens in a new tab)DOI10.1002/j.1552-4604.1981.tb01754.x (opens in a new tab)PepBankPUB-06262387
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In subjects with intact adrenal function, animal-origin ACTH1-39 produced cortisol increases comparable to synthetic ACTH1-18 at 1, 2, and 6 hours.

    In plain wordsIn subjects with intact adrenal function, ACTH1-39 increased cortisol similarly to synthetic ACTH1-18.

    Peptide
    ACTH (corticotropin)
    Outcome
    No significant changePlasma cortisol response
    Study

    n = 10

    Comparator
    0.4 mg synthetic ACTH1-18
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    40 units · intramuscularAs given in this study (human).

    Source sentences

    Summary
    Forty units of 1-39 ACTH of animal origin or 0.4 mg of synthetic 1-18 ACTH administered at 8 A.M. via either the intramuscular route to 10 subjects with intact adrenocortical function produced comparable increases in plasma cortisol at 1, 2, and 6 hours.
  2. 02HumanNon-randomized trialActivity measurement

    In subjects, intravenous crystalline ACTH1-39 increased cortisol for at least 6 but less than 12 hours, versus 16 to less than 24 hours with intramuscular gel.

    In plain wordsIn subjects, cortisol increases lasted less time after intravenous crystalline ACTH1-39 than after intramuscular ACTH1-39 gel.

    Peptide
    ACTH (corticotropin)
    Outcome
    DecreaseCortisol response duration after intravenous crystalline ACTH1-39
    Study

    n: not reported in source

    Comparator
    Intramuscular ACTH1-39 depot gel
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    40 units · intravenousAs given in this study (human).

    Measurements

    Cortisol response duration
    6 to 12 hours
    intravenous, at least 6 and less than 12
    Cortisol response duration
    16 to 24 hours
    intramuscular depot gel, at least 16 and less than 24

    Source sentences

    Summary
    The increase in plasma cortisol lasted at least 6 hours but less than 12 hours after intravenous crystalline 1-39 ACTH and at least 16 hours but less than 24 hours after the same dose of 1-39 ACTH administered as a depot gel via the intramuscular route.
  3. 03HumanNon-randomized trialActivity measurement

    In subjects, neither intravenous nor intramuscular ACTH1-39 produced a cortisol increase still evident at 24 hours.

    In plain wordsIn subjects, cortisol increases after intravenous or intramuscular ACTH1-39 were no longer evident at 24 hours.

    Peptide
    ACTH (corticotropin)
    Outcome
    No significant changeCortisol increase at 24 hours
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    40 units · intravenous and intramuscularAs given in this study (human).

    Source sentences

    Summary
    However, neither intravenous nor the intramuscular injection of 1-39 ACTH produced increases that were still evident at 24 hours.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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