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Study · Animal study (in vivo) · rat · 1980

4 results

The relationship between intramitochondrial N-acetylglutamate and activity of carbamoyl-phosphate synthetase (ammonia). The effect of glucagon.

Hensgens HE, Verhoeven AJ, Meijer AJ

European journal of biochemistry1 Jan 1980Cited by 87 (Europe PMC)

PMID6249585 (opens in a new tab)DOI10.1111/j.1432-1033.1980.tb04640.x (opens in a new tab)PepBankPUB-06249585
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, glucagon treatment before death increased liver intramitochondrial ATP concentration.

    In plain wordsIn rats, glucagon treatment increased liver mitochondrial ATP concentration compared with controls.

    Peptide
    Glucagon
    Outcome
    IncreaseIntramitochondrial ATP concentration
    Study

    ratn: not reported in source

    Liver mitochondria after glucagon dosing
    Comparator
    Control rats
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment of rats with glucagon prior to killing results not only in an increased intramitochondrial ATP concentration and an increased capacity of the mitochondria to synthesize citrulline, but also in an increased concentration of intramitochondrial N-acetylglutamate.
    1 context sentence
    Summary · context
    The relationship between urea synthesis, intracellular N-acetylglutamate and the capacity of rat-liver mitochondria to synthesize citrulline was investigated.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, glucagon treatment before death increased liver mitochondrial capacity to synthesize citrulline.

    In plain wordsIn rats, glucagon increased liver mitochondrial capacity to produce citrulline compared with controls.

    Peptide
    Glucagon
    Outcome
    IncreaseMitochondrial citrulline synthesis capacity
    Study

    ratn: not reported in source

    Liver mitochondria after glucagon dosing
    Comparator
    Control rats
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment of rats with glucagon prior to killing results not only in an increased intramitochondrial ATP concentration and an increased capacity of the mitochondria to synthesize citrulline, but also in an increased concentration of intramitochondrial N-acetylglutamate.
    1 context sentence
    Summary · context
    The relationship between urea synthesis, intracellular N-acetylglutamate and the capacity of rat-liver mitochondria to synthesize citrulline was investigated.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, glucagon treatment before death increased liver intramitochondrial N-acetylglutamate concentration.

    In plain wordsIn rats, glucagon increased liver mitochondrial N-acetylglutamate concentration compared with controls.

    Peptide
    Glucagon
    Outcome
    IncreaseIntramitochondrial N-acetylglutamate concentration
    Study

    ratn: not reported in source

    Liver mitochondria after glucagon dosing
    Comparator
    Control rats
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment of rats with glucagon prior to killing results not only in an increased intramitochondrial ATP concentration and an increased capacity of the mitochondria to synthesize citrulline, but also in an increased concentration of intramitochondrial N-acetylglutamate.
    1 context sentence
    Summary · context
    The relationship between urea synthesis, intracellular N-acetylglutamate and the capacity of rat-liver mitochondria to synthesize citrulline was investigated.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rat liver mitochondria, increased N-acetylglutamate after glucagon treatment partly explained increased citrulline synthesis capacity compared with controls.

    In plain wordsIn rats, increased mitochondrial N-acetylglutamate after glucagon partly explained greater citrulline production capacity compared with controls.

    Peptide
    Glucagon
    Outcome
    Not applicableN-acetylglutamate contribution to citrulline synthesis
    Study

    ratn: not reported in source

    Liver mitochondria after glucagon dosing
    Comparator
    Control rats
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Comparison of the rate of citrulline synthesis in mitochondria from glucagon-treated and from control rats, incubated under different conditions, shows that the increased N-acetylglutamate concentration after glucagon treatment is at least in part responsible for the observed increased capacity of t…
    1 context sentence
    Summary · context
    The relationship between urea synthesis, intracellular N-acetylglutamate and the capacity of rat-liver mitochondria to synthesize citrulline was investigated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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