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Study · Animal study (in vivo) · rat · 1980

3 results

Influence of exogenous glucocorticoids and ACTH on experimental adrenal autografts.

Srougi M, Gittes RF, Underwood RH

Investigative urology1 Jan 1980Cited by 7 (Europe PMC)

PMID6243270 (opens in a new tab)PepBankPUB-06243270
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adrenalectomized rats, porcine ACTH gel with dexamethasone produced full graft regeneration, whereas dexamethasone alone produced persistent atrophy.

    In plain wordsIn rats, porcine ACTH gel with dexamethasone restored adrenal grafts compared with dexamethasone alone.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreaseAdrenal graft regeneration
    Study

    ratn: not reported in source

    Adrenalectomized rats with adrenal autografts
    Comparator
    Dexamethasone alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Porcine ACTH plus dexamethasone resulted in full regeneration with cellular hypertrophy exceeding that of controls
    3 context sentences
    Summary · context
    Dexamethasone treatment completely suppressed corticosterone and resulted in striking atrophy persistent at 80 days.
    Summary · context
    Minced adrenal autografts under the renal capsule in adrenalectomized rats were studied by means of serial plasma corticosterone determination and histologic examination.
    Summary · context
    The effect of daily treatment with dexamethasone with or without daily porcine adrenocorticotropic hormone (ACTH) gel was determined.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In adrenalectomized rats receiving dexamethasone, the effect of porcine ACTH gel lasted only 12 hours.

    In plain wordsIn rats receiving dexamethasone, porcine ACTH gel acted for only 12 hours.

    Peptide
    ACTH (corticotropin)
    Outcome
    Not applicableACTH gel effect duration
    Study

    ratn: not reported in source

    Adrenalectomized rats with adrenal autografts
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Effect duration
    12 hr
    ACTH gel

    Source sentences

    Summary
    but the corticosterone levels in samples drawn just before the scheduled ACTH injections were very low because the effect of ACTH gel lasted only 12 hr and endogenous ACTH was suppressed.
    2 context sentences
    Summary · context
    Minced adrenal autografts under the renal capsule in adrenalectomized rats were studied by means of serial plasma corticosterone determination and histologic examination.
    Summary · context
    The effect of daily treatment with dexamethasone with or without daily porcine adrenocorticotropic hormone (ACTH) gel was determined.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adrenalectomized rats, plasma corticosterone at 40 days was 5.1 ± 4.8 with porcine ACTH plus dexamethasone versus 3.8 ± 6.1 with dexamethasone.

    In plain wordsIn rats, plasma corticosterone was 5.1 with porcine ACTH plus dexamethasone versus 3.8 with dexamethasone at 40 days.

    Peptide
    ACTH (corticotropin)
    Outcome
    Direction not reportedPlasma corticosterone at 40 days
    Study

    ratn: not reported in source

    Adrenalectomized rats with adrenal autografts
    Comparator
    Dexamethasone alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Plasma corticosterone
    5.1 not stated
    dexamethasone plus porcine ACTH
    SD
    4.8 not stated
    dexamethasone plus porcine ACTH
    Plasma corticosterone
    3.8 not stated
    dexamethasone alone
    SD
    6.1 not stated
    dexamethasone alone

    Source sentences

    Summary
    Plasma levels at 40 days were 22.8 +/- 5.9 (SD) for controls, 3.8 +/- 6.1 for dexamethasone, and 5.1 +/- 4.8 for dexamethasone plus porcine ACTH.
    2 context sentences
    Summary · context
    Minced adrenal autografts under the renal capsule in adrenalectomized rats were studied by means of serial plasma corticosterone determination and histologic examination.
    Summary · context
    The effect of daily treatment with dexamethasone with or without daily porcine adrenocorticotropic hormone (ACTH) gel was determined.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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