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Study · Non-randomized trial · 1984

5 results

A comparative study on glucagon effect between McArdle disease and Tarui disease.

Mineo I, Kono N, Shimizu T, Sumi S, Nonaka K, Tarui S

Muscle & nerve1 Sept 1984Cited by 23 (Europe PMC)

PMID6242422 (opens in a new tab)DOI10.1002/mus.880070706 (opens in a new tab)PepBankPUB-06242422
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with McArdle disease, glucagon pretreatment relieved muscular symptoms during exercise.

    In plain wordsIn patients with McArdle disease, glucagon pretreatment reduced muscle symptoms during exercise.

    Peptide
    Glucagon
    Outcome
    DecreaseExercise-related muscular symptoms in McArdle disease
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with glucagon relieved patients with McArdle disease from muscular symptoms during exercise and enhanced exercise performance, though it did not produce any improvement in patients with Tarui disease.
    1 context sentence
    Summary · context
    The difference in glucagon effect between the two diseases was clearly demonstrated in the bicycle ergometer exercise tests.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with McArdle disease, glucagon pretreatment enhanced exercise performance.

    In plain wordsIn patients with McArdle disease, glucagon pretreatment improved exercise performance.

    Peptide
    Glucagon
    Outcome
    IncreaseExercise performance in McArdle disease
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with glucagon relieved patients with McArdle disease from muscular symptoms during exercise and enhanced exercise performance, though it did not produce any improvement in patients with Tarui disease.
    1 context sentence
    Summary · context
    The difference in glucagon effect between the two diseases was clearly demonstrated in the bicycle ergometer exercise tests.
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients with Tarui disease, glucagon pretreatment did not produce clinical improvement.

    In plain wordsIn patients with Tarui disease, glucagon pretreatment did not produce improvement.

    Peptide
    Glucagon
    Outcome
    No significant changeClinical improvement in Tarui disease
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with glucagon relieved patients with McArdle disease from muscular symptoms during exercise and enhanced exercise performance, though it did not produce any improvement in patients with Tarui disease.
    1 context sentence
    Summary · context
    The difference in glucagon effect between the two diseases was clearly demonstrated in the bicycle ergometer exercise tests.
  4. 04HumanNon-randomized trialMechanism

    In patients with McArdle disease, exercise significantly increased lactate production after glucagon injection.

    In plain wordsIn patients with McArdle disease, exercise increased lactate production after glucagon injection.

    Peptide
    Glucagon
    Outcome
    IncreaseExercise-induced lactate production in McArdle disease
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated · injectionAs given in this study (human).

    Source sentences

    Summary
    In addition, the semi-ischemic forearm exercise tests performed after glucagon injection showed that increased lactate production was significantly induced by exercise in McArdle disease, but it was not the case in Tarui disease.
    1 context sentence
    Summary · context
    The difference in glucagon effect between the two diseases was clearly demonstrated in the bicycle ergometer exercise tests.
  5. 05HumanNon-randomized trialMechanism

    In patients with Tarui disease, exercise did not significantly increase lactate production after glucagon injection.

    In plain wordsIn patients with Tarui disease, exercise did not significantly increase lactate production after glucagon injection.

    Peptide
    Glucagon
    Outcome
    No significant changeExercise-induced lactate production in Tarui disease
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated · injectionAs given in this study (human).

    Source sentences

    Summary
    In addition, the semi-ischemic forearm exercise tests performed after glucagon injection showed that increased lactate production was significantly induced by exercise in McArdle disease, but it was not the case in Tarui disease.
    1 context sentence
    Summary · context
    The difference in glucagon effect between the two diseases was clearly demonstrated in the bicycle ergometer exercise tests.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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