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Study · Non-randomized trial · n = 4 · 1984

4 results

Treatment of precocious puberty with LHRH analogue in combination with cyproterone acetate-further experience.

Kauli R, Pertzelan A, Ben-Zeev Z, Lewin RP, Kaufman H, Schally AM, Schally AV, Laron Z

Clinical endocrinology1 Apr 1984Cited by 25 (Europe PMC)

PMID6232020 (opens in a new tab)DOI10.1111/j.1365-2265.1984.tb03433.x (opens in a new tab)PepBankPUB-06232020
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In four children with progressive adrenarche despite gonadotropin suppression, increasing the triptorelin dose was ineffective.

    In plain wordsIn four children with early puberty, increasing triptorelin did not stop progressive adrenal puberty signs.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeAdrenarche progression despite dose increase
    Study

    n = 4

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In four patients who showed progression of the angrogen-dependent signs (adrenarche), despite suppression of gonadotrophins, increasing the dosage of the LHRH analogue was ineffective and combined therapy with CyA was reinstituted in three of them because of accelerated growth and bone maturation.
    2 context sentences
    Summary · context
    Six girls and one boy with precocious puberty were treated with a superactive LHRH analogue (D-TRP6-LHRH) for periods ranging from 1 year to 2 years and 3 months.
    Summary · context
    In the first phase of the treatment it was administered in combination with cyproterone acetate (CyA) to counteract an early stimulatory effect until inhibition of gonadotrophin secretion was achieved.

Studies that did not test the peptide alone3

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In children with precocious puberty, the triptorelin regimen with initial cyproterone acetate arrested or reversed gonadarche.

    In plain wordsIn children with early puberty, a triptorelin regimen with initial cyproterone acetate stopped or reversed gonadal puberty signs.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseGonadarche
    Study

    n = 7

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The gonadotrophin-dependent signs i.e. gonadarche, showed sustained arrest and even regression.
    2 context sentences
    Summary · context
    Six girls and one boy with precocious puberty were treated with a superactive LHRH analogue (D-TRP6-LHRH) for periods ranging from 1 year to 2 years and 3 months.
    Summary · context
    In the first phase of the treatment it was administered in combination with cyproterone acetate (CyA) to counteract an early stimulatory effect until inhibition of gonadotrophin secretion was achieved.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In children with precocious puberty, gonadal sex steroids decreased during a triptorelin regimen with initial cyproterone acetate.

    In plain wordsIn children with early puberty, gonadal sex steroids decreased during a triptorelin regimen with initial cyproterone acetate.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseGonadal sex steroids
    Study

    n = 7

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Gonadal sex steroids decreased but the adrenal androgens were unaffected.
    2 context sentences
    Summary · context
    Six girls and one boy with precocious puberty were treated with a superactive LHRH analogue (D-TRP6-LHRH) for periods ranging from 1 year to 2 years and 3 months.
    Summary · context
    In the first phase of the treatment it was administered in combination with cyproterone acetate (CyA) to counteract an early stimulatory effect until inhibition of gonadotrophin secretion was achieved.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  3. 04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In children with precocious puberty, adrenal androgens remained unchanged during a triptorelin regimen with initial cyproterone acetate.

    In plain wordsIn children with early puberty, adrenal androgens did not change during a triptorelin regimen with initial cyproterone acetate.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeAdrenal androgens
    Study

    n = 7

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Gonadal sex steroids decreased but the adrenal androgens were unaffected.
    2 context sentences
    Summary · context
    Six girls and one boy with precocious puberty were treated with a superactive LHRH analogue (D-TRP6-LHRH) for periods ranging from 1 year to 2 years and 3 months.
    Summary · context
    In the first phase of the treatment it was administered in combination with cyproterone acetate (CyA) to counteract an early stimulatory effect until inhibition of gonadotrophin secretion was achieved.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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