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Study · Animal study (in vivo) · rat · 1980

2 results

Sites of paradoxical action of the LHRH agonist (D-Trp6)-LHRH.

Arimura A, Talbot S, Serafini PC, Schally AV

International journal of fertility1 Jan 1980Cited by 3 (Europe PMC)

PMID6108923 (opens in a new tab)PepBankPUB-06108923
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In intact and hypophysectomized rats, triptorelin reduced ovarian LH/hCG receptors versus saline at doses as low as 0.2 microgram/day.

    In plain wordsIn rats with or without a pituitary gland, triptorelin reduced ovarian hormone receptors compared with saline.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseOvarian LH/hCG receptors
    Study

    ratn: not reported in source

    Immature intact and hypophysectomized gonadotropin-primed female rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    0.2 or 2 micrograms daily · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    A significant reduction (P < 0.01) of ovarian LH/hCG receptors in both intact and hypophysectomized rats was observed following administration of (D-Trp6)-LHRH in doses as low as 0.2 microgram/day.
    2 context sentences
    Summary · context
    Immature intact and hypophysectomized female rats, which were primed with gonadotropin, were injected subcutaneously with 0.9% saline or 0.2 or 2 microgram of (D-Trp6)-LHRH once daily for 7 days.
    Summary · context
    Ovarian LH/hCG receptors and ovarian weight were measured 24 hours after the last analog or saline injection.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, triptorelin at 2 micrograms daily significantly decreased ovarian weight compared with saline.

    In plain wordsIn rats, triptorelin reduced ovarian weight compared with saline.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseOvarian weight
    Study

    ratn: not reported in source

    Immature intact and hypophysectomized gonadotropin-primed female rats
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    2 micrograms daily · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    A significant decrease was observed in the ovarian weight of 2 microgram-treated rats (P < 0.05).
    2 context sentences
    Summary · context
    Immature intact and hypophysectomized female rats, which were primed with gonadotropin, were injected subcutaneously with 0.9% saline or 0.2 or 2 microgram of (D-Trp6)-LHRH once daily for 7 days.
    Summary · context
    Ovarian LH/hCG receptors and ovarian weight were measured 24 hours after the last analog or saline injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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