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Study · Non-randomized trial · n = 9 · 1974

10 results

Effects of glucagon on lipolysis and ketogenesis in normal and diabetic men.

Liljenquist JE, Bomboy JD, Lewis SB, Sinclair-Smith BC, Felts PW, Lacy WW, Crofford OB, Liddle GW

The Journal of clinical investigation1 Jan 1974Cited by 104 (Europe PMC)

PMID4808635 (opens in a new tab)PMCIDPMC301453 (opens in a new tab)DOI10.1172/jci107537 (opens in a new tab)PepBankPUB-04808635
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

  1. 01HumanNon-randomized trialPharmacokinetics

    In normal and insulin-dependent diabetic men, glucagon infusion produced a mean circulating plasma glucagon level of 4,420 pg/ml.

    In plain wordsIn normal and diabetic men, glucagon infusion produced an average blood glucagon level of 4,420 pg/ml.

    Peptide
    Glucagon
    Outcome
    Not applicableCirculating plasma glucagon
    Study

    n = 9

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    50 ng/kg/min · infusionAs given in this study (human).

    Measurements

    Mean plasma glucagon
    4420 pg/ml
    glucagon infusion

    Source sentences

    Summary
    The glucagon infusion resulted in a mean circulating plasma level of 4,420 pg/ml.
    1 context sentence
    Summary · context
    The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men.
  2. 02HumanNon-randomized trialMechanism

    In diabetic men, glucagon significantly increased arterial glycerol compared with saline infusion.

    In plain wordsIn diabetic men, glucagon increased arterial glycerol compared with saline infusion.

    Peptide
    Glucagon
    Outcome
    IncreaseArterial glycerol in diabetic subjects
    Study

    n = 9

    Comparator
    Saline infusion
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    50 ng/kg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    Arterial glycerol and net splanchnic total ketone production in these subjects rose significantly (P=<0.05) when compared with the results in four diabetics who received a saline infusion after undergoing the same catheterization procedure.
    1 context sentence
    Summary · context
    The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men.
  3. 03HumanNon-randomized trialMechanism

    In diabetic men, glucagon significantly increased net splanchnic total ketone production compared with saline infusion.

    In plain wordsIn diabetic men, glucagon increased net splanchnic ketone production compared with saline infusion.

    Peptide
    Glucagon
    Outcome
    IncreaseSplanchnic total ketone production in diabetic subjects
    Study

    n = 9

    Comparator
    Saline infusion
    Outcome group
    Ketogenesis · Metabolic and weight
    Studied dose
    50 ng/kg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    Arterial glycerol and net splanchnic total ketone production in these subjects rose significantly (P=<0.05) when compared with the results in four diabetics who received a saline infusion after undergoing the same catheterization procedure.
    1 context sentence
    Summary · context
    The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men.
  4. 04HumanNon-randomized trialMechanism

    In insulin-dependent diabetic men, glucagon did not stimulate insulin secretion, as indicated by unchanged C-peptide immunoreactivity.

    In plain wordsIn diabetic men, glucagon did not increase insulin secretion, as indicated by unchanged C-peptide levels.

    Peptide
    Glucagon
    Outcome
    No significant changeInsulin secretion in diabetic subjects
    Study

    n = 5

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    50 ng/kg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    In contrast, the diabetic subjects secreted no insulin (no rise in C-peptide immunoreactivity) in response to glucagon.
    1 context sentence
    Summary · context
    The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men.
  5. 05HumanNon-randomized trialMechanism

    In insulin-dependent diabetic men, net splanchnic glucose production rose markedly during glucagon stimulation.

    In plain wordsIn diabetic men, glucagon markedly increased net splanchnic glucose production.

    Peptide
    Glucagon
    Outcome
    IncreaseSplanchnic glucose production in diabetic subjects
    Study

    n = 5

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    50 ng/kg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    Net splanchnic glucose production rose markedly during glucagon stimulation in the normals and diabetics despite the marked rise in insulin in the normals.
    1 context sentence
    Summary · context
    The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men.
  6. 06HumanNon-randomized trialMechanism

    In normal men, glucagon infusion increased immunoreactive insulin levels.

    In plain wordsIn normal men, glucagon infusion increased blood insulin levels.

    Peptide
    Glucagon
    Outcome
    IncreaseImmunoreactive insulin in normal subjects
    Study

    n = 4

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    50 ng/kg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    In the normal subjects, the glucagon infusion resulted in stimulation of insulin secretion indicated by rising levels of immunoreactive insulin and C-peptide immunoreactivity.
    1 context sentence
    Summary · context
    The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men.
  7. 07HumanNon-randomized trialMechanism

    In normal men, glucagon infusion increased C-peptide immunoreactivity.

    In plain wordsIn normal men, glucagon infusion increased C-peptide levels.

    Peptide
    Glucagon
    Outcome
    IncreaseC-peptide immunoreactivity in normal subjects
    Study

    n = 4

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    50 ng/kg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    In the normal subjects, the glucagon infusion resulted in stimulation of insulin secretion indicated by rising levels of immunoreactive insulin and C-peptide immunoreactivity.
    1 context sentence
    Summary · context
    The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men.
  8. 08HumanNon-randomized trialMechanism

    In normal men, arterial glycerol concentration declined markedly during glucagon infusion.

    In plain wordsIn normal men, glucagon infusion markedly reduced arterial glycerol.

    Peptide
    Glucagon
    Outcome
    DecreaseArterial glycerol in normal subjects
    Study

    n = 4

    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    50 ng/kg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    Arterial glycerol concentration (an index of lipolysis) declined markedly and net splanchnic total ketone production was virtually abolished.
    1 context sentence
    Summary · context
    The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men.
  9. 09HumanNon-randomized trialMechanism

    In normal men, glucagon infusion virtually abolished net splanchnic total ketone production.

    In plain wordsIn normal men, glucagon infusion almost eliminated net ketone production in the splanchnic region.

    Peptide
    Glucagon
    Outcome
    DecreaseSplanchnic total ketone production in normal subjects
    Study

    n = 4

    Outcome group
    Ketogenesis · Metabolic and weight
    Studied dose
    50 ng/kg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    Arterial glycerol concentration (an index of lipolysis) declined markedly and net splanchnic total ketone production was virtually abolished.
    1 context sentence
    Summary · context
    The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men.
  10. 10HumanNon-randomized trialMechanism

    In normal men, net splanchnic glucose production rose markedly during glucagon stimulation despite increased insulin.

    In plain wordsIn normal men, glucagon markedly increased net splanchnic glucose production despite increased insulin.

    Peptide
    Glucagon
    Outcome
    IncreaseSplanchnic glucose production in normal subjects
    Study

    n = 4

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    50 ng/kg/min · infusionAs given in this study (human).

    Source sentences

    Summary
    Net splanchnic glucose production rose markedly during glucagon stimulation in the normals and diabetics despite the marked rise in insulin in the normals.
    1 context sentence
    Summary · context
    The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

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