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Study · Not a test of the peptide alone · 1972

4 results

Glucagon-initiated human growth hormone release: a comparative study.

Cain JP, Williams GH, Dluhy RG

Canadian Medical Association journal1 Oct 1972Cited by 35 (Europe PMC)

PMID4665093 (opens in a new tab)PMCIDPMC1940964 (opens in a new tab)PepBankPUB-04665093
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Glucagon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Glucagon.

  1. 01HumanNot a test of Glucagon aloneNon-randomized trialActivity measurement

    In patients with suspected pituitary insufficiency, abnormal growth hormone responses to glucagon were the most frequent functional abnormality.

    In plain wordsIn patients with suspected pituitary insufficiency, an abnormal growth hormone response to glucagon was the most frequent functional abnormality.

    Peptide
    Glucagon
    Outcome
    Not applicableAbnormal growth hormone response in suspected pituitary insufficiency
    Study

    n = 49

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    HGH response to glucagon was also studied in 49 patients with suspected pituitary insufficiency, of whom 25 also later received an arginine infusion; an abnormal response to glucagon was the most frequent functional abnormality
    1 context sentence
    Summary · context
    Human growth hormone (HGH) responses in 20 healthy adults to subcutaneous glucagon, arginine infusion and tolbutamide and insulin hypoglycemia were compared.

    In this study, Glucagon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glucagon.

  2. 02HumanNot a test of Glucagon aloneNon-randomized trialActivity measurement

    In patients with suspected pituitary insufficiency tested with glucagon, growth hormone was often the only anterior pituitary hormone with detectable deficiency.

    In plain wordsIn patients tested with glucagon for suspected pituitary insufficiency, growth hormone was often the only pituitary hormone with detectable deficiency.

    Peptide
    Glucagon
    Outcome
    Not applicableIsolated growth hormone deficiency detection
    Study

    n = 49

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    an abnormal response to glucagon was the most frequent functional abnormality and often HGH was the only anterior pituitary hormone of which a deficiency was detectable.
    1 context sentence
    Summary · context
    Human growth hormone (HGH) responses in 20 healthy adults to subcutaneous glucagon, arginine infusion and tolbutamide and insulin hypoglycemia were compared.

    In this study, Glucagon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glucagon.

  3. 03HumanNot a test of Glucagon aloneNon-randomized trialActivity measurement

    In healthy adults, growth hormone increased after glucagon, as it did after arginine, tolbutamide and insulin tests.

    In plain wordsIn healthy adults, growth hormone increased after glucagon and after each of the other stimulation tests.

    Peptide
    Glucagon
    Outcome
    IncreaseGrowth hormone response in healthy adults
    Study

    n = 20

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    HGH rose in all four tests.
    1 context sentence
    Summary · context
    Human growth hormone (HGH) responses in 20 healthy adults to subcutaneous glucagon, arginine infusion and tolbutamide and insulin hypoglycemia were compared.

    In this study, Glucagon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glucagon.

  4. 04HumanNot a test of Glucagon aloneNon-randomized trialActivity measurement

    In seven subjects, including two healthy controls and five patients, growth hormone responses were normal with glucagon but subnormal with arginine.

    In plain wordsIn seven subjects, growth hormone responses were normal after glucagon but below normal after arginine.

    Peptide
    Glucagon
    Outcome
    Not applicableNormal glucagon response despite subnormal arginine response
    Study

    n = 7

    Comparator
    Arginine
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In seven subjects (two healthy controls and five patients with suspected hypopituitarism) there was a subnormal HGH response to arginine but a normal response to glucagon.
    1 context sentence
    Summary · context
    Human growth hormone (HGH) responses in 20 healthy adults to subcutaneous glucagon, arginine infusion and tolbutamide and insulin hypoglycemia were compared.

    In this study, Glucagon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glucagon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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