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Study · Non-randomized trial · n = 8 · 1985

5 results

Ovulation induction with pulsatile intravenous GnRH.

Malo JW, Bezdicek B, Campbell E, Pavelka DA, Covato T

The Journal of reproductive medicine1 Dec 1985Cited by 1 (Europe PMC)

PMID3908673 (opens in a new tab)PepBankPUB-03908673
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In eight patients with hypogonadotropic hypogonadism, pulsatile intravenous GnRH produced documented ovulation of a single dominant follicle in 12 of 15 cycles (80%).

    In plain wordsIn eight patients, pulsed intravenous GnRH led to ovulation in 12 of 15 cycles (80%).

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseOvulation of a single dominant follicle
    Study

    n = 8

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenous · mean of 12.2 days per cycleAs given in this study (human).

    Measurements

    Ovulation
    12 cycles
    15 cycles
    Ovulation rate
    80%
    15 cycles

    Source sentences

    Summary
    Basal body temperatures and ultrasound documented ovulation of a single, dominant follicle in 12 cycles (80%).
    1 context sentence
    Summary · context
    We used commercially available GnRH (Factrel, Ayerst Laboratories) and the Auto Syringe AS6H Infusion Pump for ovulation induction in such patients. Eight patients completed 15 cycles of pulsatile intravenous GnRH therapy.
  2. 02HumanNon-randomized trialEfficacy outcome

    In eight patients treated with pulsatile intravenous GnRH, there were four singleton pregnancies.

    In plain wordsIn eight patients treated with pulsed intravenous GnRH, there were four single-baby pregnancies.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseSingleton pregnancies
    Study

    n = 8

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenous · mean of 12.2 days per cycleAs given in this study (human).

    Source sentences

    Summary
    There were four singleton pregnancies.
    1 context sentence
    Summary · context
    We used commercially available GnRH (Factrel, Ayerst Laboratories) and the Auto Syringe AS6H Infusion Pump for ovulation induction in such patients. Eight patients completed 15 cycles of pulsatile intravenous GnRH therapy.
  3. 03HumanNon-randomized trialSafety outcome

    In eight patients treated with pulsatile intravenous GnRH, no complications were observed.

    In plain wordsIn eight patients treated with pulsed intravenous GnRH, no complications were seen.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    No significant changeComplications
    Study

    n = 8

    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenous · mean of 12.2 days per cycleAs given in this study (human).

    Source sentences

    Summary
    No complications were observed
    1 context sentence
    Summary · context
    We used commercially available GnRH (Factrel, Ayerst Laboratories) and the Auto Syringe AS6H Infusion Pump for ovulation induction in such patients. Eight patients completed 15 cycles of pulsatile intravenous GnRH therapy.
  4. 04HumanNon-randomized trialEfficacy outcome

    With pulsatile intravenous GnRH, the overall corrected pregnancy rate was four pregnancies in ten cycles (40%).

    In plain wordsWith pulsed intravenous GnRH, four pregnancies occurred in ten cycles (40%).

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseCorrected pregnancy rate per cycle
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenous · mean of 12.2 days per cycleAs given in this study (human).

    Measurements

    Corrected pregnancy rate per cycle
    40%
    ten cycles

    Source sentences

    Summary
    The overall corrected pregnancy rate was four pregnancies for ten cycles (40%)
    1 context sentence
    Summary · context
    We used commercially available GnRH (Factrel, Ayerst Laboratories) and the Auto Syringe AS6H Infusion Pump for ovulation induction in such patients. Eight patients completed 15 cycles of pulsatile intravenous GnRH therapy.
  5. 05HumanNon-randomized trialEfficacy outcome

    With pulsatile intravenous GnRH, the abstract reports an overall corrected pregnancy rate of 67% in six patients, alongside four pregnancies in ten cycles (40%).

    In plain wordsWith pulsed intravenous GnRH, the abstract reports a corrected pregnancy rate of 67% in six patients.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseCorrected pregnancy rate per patient
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenous · mean of 12.2 days per cycleAs given in this study (human).

    Measurements

    Patients with pregnancy
    67%
    six patients

    Source sentences

    Summary
    in six patients (67%).
    1 context sentence
    Summary · context
    We used commercially available GnRH (Factrel, Ayerst Laboratories) and the Auto Syringe AS6H Infusion Pump for ovulation induction in such patients. Eight patients completed 15 cycles of pulsatile intravenous GnRH therapy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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