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Study · Animal study (in vivo) · new zealand white rabbit · 1985

3 results

Development of an animal model for quantitatively evaluating effects of drugs on endometriosis.

Hahn DW, Carraher RP, Foldesy RG, McGuire JL

Fertility and sterility1 Sept 1985Cited by 12 (Europe PMC)

PMID3896862 (opens in a new tab)DOI10.1016/s0015-0282(16)48869-2 (opens in a new tab)PepBankPUB-03896862
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with induced endometriosis, daily histrelin reduced ectopic implant weight to 21.7 mg within 8 weeks.

    In plain wordsIn rabbits with endometriosis, histrelin reduced implant weight to 21.7 mg within 8 weeks.

    Peptide
    Histrelin
    Outcome
    DecreaseEctopic implant weight
    Study

    New Zealand White rabbitn: not reported in source

    transplanted endometrial implants
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (New Zealand White rabbit).

    Measurements

    Implant weight
    21.7 mg
    histrelin

    Source sentences

    Summary
    Daily subcutaneous administration of a luteinizing hormone-releasing hormone agonist, histrelin, or oral administration of danazol, reduced the ectopic implant weight within 8 weeks to 21.7 and 46.0 mg, respectively.
    1 context sentence
    Summary · context
    Endometriosis was induced in New Zealand White rabbits by transplanting endometrial sections into various sites throughout the peritoneum.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with induced endometriosis, histrelin reduced the number of endometrial glands.

    In plain wordsIn rabbits with endometriosis, histrelin reduced the number of endometrial glands.

    Peptide
    Histrelin
    Outcome
    DecreaseEndometrial gland number
    Study

    New Zealand White rabbitn: not reported in source

    transplanted endometrial implants
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (New Zealand White rabbit).

    Source sentences

    Summary
    Furthermore, histologic analysis of the endometriomas showed that ovariectomy, histrelin, or danazol treatment reduced the number of endometrial glands and atrophied the stroma.
    1 context sentence
    Summary · context
    Endometriosis was induced in New Zealand White rabbits by transplanting endometrial sections into various sites throughout the peritoneum.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with induced endometriosis, histrelin produced stromal atrophy.

    In plain wordsIn rabbits with endometriosis, histrelin caused the stroma to shrink.

    Peptide
    Histrelin
    Outcome
    IncreaseEndometrioma stromal atrophy
    Study

    New Zealand White rabbitn: not reported in source

    transplanted endometrial implants
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (New Zealand White rabbit).

    Source sentences

    Summary
    Furthermore, histologic analysis of the endometriomas showed that ovariectomy, histrelin, or danazol treatment reduced the number of endometrial glands and atrophied the stroma.
    1 context sentence
    Summary · context
    Endometriosis was induced in New Zealand White rabbits by transplanting endometrial sections into various sites throughout the peritoneum.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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