Skip to content

Study · Animal study (in vivo) · mouse · 1985

7 results

[Differentiation characteristics of circulating and bone marrow hematopoietic stem cells and the effect of thymus factors].

Popov BV, Ergakova EV

Biulleten' eksperimental'noi biologii i meditsiny1 May 1985

PMID3839146 (opens in a new tab)DOI10.1007/bf00837283 (opens in a new tab)PepBankPUB-03839146
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized and sham-operated mice, thymalin markedly lowered erythroid specialization of blood hematopoietic stem cells.

    In plain wordsIn mice with or without thymus removal, thymalin reduced red blood cell specialization of circulating stem cells.

    Peptide
    Thymalin
    Outcome
    DecreaseErythroid specialization of blood HSC
    Study

    mousen: not reported in source

    Thymectomized and sham-operated mice
    Outcome group
    Cell proliferation and differentiation · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the contrary, in experiments made in vivo, it dramatically lowers erythroid specialization of blood HSC in thymectomized and sham-operated mice, which is followed by the diminution of the total number of circulating HSC.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized and sham-operated mice, thymalin reduced the total number of circulating hematopoietic stem cells.

    In plain wordsIn mice with or without thymus removal, thymalin reduced the total number of circulating blood stem cells.

    Peptide
    Thymalin
    Outcome
    DecreaseTotal circulating HSC number
    Study

    mousen: not reported in source

    Thymectomized and sham-operated mice
    Outcome group
    Cell proliferation and differentiation · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the contrary, in experiments made in vivo, it dramatically lowers erythroid specialization of blood HSC in thymectomized and sham-operated mice, which is followed by the diminution of the total number of circulating HSC.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized mice, thymalin injection completely normalized bone marrow stem cell differentiation.

    In plain wordsIn mice without a thymus, thymalin injection returned bone marrow stem cell development to normal.

    Peptide
    Thymalin
    Outcome
    Not applicableBone marrow stem cell differentiation
    Study

    mousen: not reported in source

    Thymectomized mice
    Outcome group
    Cell proliferation and differentiation · Whole body
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Differentiation of thymectomized mice bone marrow stem cells is completely normalized after thymalin injection.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In sham-operated and thymectomized mice, thymalin-stimulated HSC resembled normal mouse bone marrow cells in differentiation trend.

    In plain wordsIn sham-operated and thymectomized mice, thymalin-stimulated stem cells developed similarly to bone marrow cells from normal mice.

    Peptide
    Thymalin
    Outcome
    Not applicableHSC differentiation trend
    Study

    mousen: not reported in source

    Sham-operated and thymectomized mice
    Comparator
    Bone marrow cells of normal mice
    Outcome group
    Cell proliferation and differentiation · Whole body
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Sham-operated and thymectomized animals' HSC stimulated by thymalin injection become similar to bone marrow cells of normal mice as regards the trend of differentiation.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, the study attributed thymalin's HSC effects to an environmental component present in bone marrow but absent from peripheral blood.

    In plain wordsIn mice, the study linked thymalin's stem cell effects to a component in bone marrow that was absent from peripheral blood.

    Peptide
    Thymalin
    Outcome
    Not applicableEnvironmental mediation of HSC response
    Study

    mousen: not reported in source

    Thymectomized and sham-operated mice
    Outcome group
    Cell proliferation and differentiation · Whole body
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    The influence of thymalin on HSC is mediated by the environmental component which is present in the bone marrow and absent from the peripheral blood.
    2 context sentences
    Summary · context
    On the contrary, in experiments made in vivo, it dramatically lowers erythroid specialization of blood HSC in thymectomized and sham-operated mice, which is followed by the diminution of the total number of circulating HSC.
    Summary · context
    Sham-operated and thymectomized animals' HSC stimulated by thymalin injection become similar to bone marrow cells of normal mice as regards the trend of differentiation.
  6. 06LabIn vitro (cells)Efficacy outcome

    In vitro, thymalin did not influence the number of circulating hematopoietic stem cells.

    In plain wordsIn cells, thymalin did not change the number of circulating blood stem cells.

    Peptide
    Thymalin
    Outcome
    No significant changeCirculating HSC number in vitro
    Study

    n: not reported in source

    Circulating hematopoietic stem cells
    Outcome group
    Cell proliferation and differentiation · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In in-vitro experiments, thymalin does not influence the number or differentiation of circulating HSC.
  7. 07LabIn vitro (cells)Efficacy outcome

    In vitro, thymalin did not influence circulating hematopoietic stem cell differentiation.

    In plain wordsIn cells, thymalin did not change how circulating blood stem cells developed.

    Peptide
    Thymalin
    Outcome
    No significant changeCirculating HSC differentiation in vitro
    Study

    n: not reported in source

    Circulating hematopoietic stem cells
    Outcome group
    Cell proliferation and differentiation · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In in-vitro experiments, thymalin does not influence the number or differentiation of circulating HSC.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.