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Study · Animal study (in vivo) · mouse · 1986

6 results

[Colony-forming units of the bone marrow and spleen of immunodeficient mice after stimulation of the cells with thymalin].

Val'kovich EI, Popov BV, Rakovshchik AL

Arkhiv anatomii, gistologii i embriologii1 Sept 1986

PMID3789935 (opens in a new tab)PepBankPUB-03789935
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In thymectomized mice, thymalin stimulated granulocytic colony growth from splenic colony-forming units in vivo.

    In plain wordsIn mice with the thymus removed, thymalin increased granulocytic colony growth from spleen cells.

    Peptide
    Thymalin
    Outcome
    IncreaseSplenic CFU granulocytic colony growth
    Study

    mousen: not reported in source

    Thymectomized mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Polypeptide preparation of the thymus--thymalin stimulates growth of the granulocytic colonies from the splenic CFUs in thymectomized mice both in in vivo and in vitro experiments.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, thymalin normalized bone marrow colony-forming unit differentiation in vivo only.

    In plain wordsIn mice, thymalin normalized bone marrow cell differentiation only in the living animal experiment.

    Peptide
    Thymalin
    Outcome
    Direction not reportedBone marrow CFU differentiation
    Study

    mousen: not reported in source

    Thymectomized mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Differentiation of the bone marrow CFUs is normalized under the effect of thymalin in in vivo experiment only.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In thymectomized mice, thymalin stimulation revealed activation of a splenic T-cell clone that enhances granulocytic differentiation.

    In plain wordsIn mice with the thymus removed, thymalin stimulation revealed activation of a spleen T-cell clone involved in granulocytic differentiation.

    Peptide
    Thymalin
    Outcome
    IncreaseSplenic T-cell clone activation
    Study

    mousen: not reported in source

    Thymectomized mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Activation of this clone in the spleen is revealed at thymectomy and stimulation of the cells with thymalin both in in vivo and in vitro experiments.
    1 context sentence
    Summary · context
    The data obtained confirm the suggestion made by R. V. Petrov on existence of T-cell clone, enhancing CFUs differentiation in granulocytic direction.
  4. 04LabIn vitro (cells)Mechanism

    In vitro, thymalin stimulated granulocytic colony growth from splenic colony-forming units of thymectomized mice.

    In plain wordsIn lab tests with spleen cells from mice with the thymus removed, thymalin increased granulocytic colony growth.

    Peptide
    Thymalin
    Outcome
    IncreaseSplenic CFU granulocytic colony growth
    Study

    mousen: not reported in source

    Splenic CFUs from thymectomized mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Polypeptide preparation of the thymus--thymalin stimulates growth of the granulocytic colonies from the splenic CFUs in thymectomized mice both in in vivo and in vitro experiments.
  5. 05LabIn vitro (cells)Mechanism

    In vitro, thymalin did not normalize bone marrow colony-forming unit differentiation, which normalized only in vivo.

    In plain wordsIn lab tests, thymalin did not normalize bone marrow cell differentiation. Normalization occurred only in living mice.

    Peptide
    Thymalin
    Outcome
    Direction not reportedBone marrow CFU differentiation normalization
    Study

    mousen: not reported in source

    Bone marrow CFUs
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Differentiation of the bone marrow CFUs is normalized under the effect of thymalin in in vivo experiment only.
  6. 06LabIn vitro (cells)Mechanism

    In vitro, thymalin stimulation revealed activation of a splenic T-cell clone that enhances granulocytic differentiation after thymectomy.

    In plain wordsIn lab tests with cells from mice with the thymus removed, thymalin stimulation revealed activation of a spleen T-cell clone.

    Peptide
    Thymalin
    Outcome
    IncreaseSplenic T-cell clone activation
    Study

    mousen: not reported in source

    Splenic cells from thymectomized mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Activation of this clone in the spleen is revealed at thymectomy and stimulation of the cells with thymalin both in in vivo and in vitro experiments.
    1 context sentence
    Summary · context
    The data obtained confirm the suggestion made by R. V. Petrov on existence of T-cell clone, enhancing CFUs differentiation in granulocytic direction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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