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Study · Animal study (in vivo) · rabbit · 1986

3 results

Absorption of 1-deamino-8-D-arginine vasopressin from different regions of the gastrointestinal tract in rabbits.

Lundin S, Vilhardt H

Acta endocrinologica1 Jul 1986Cited by 30 (Europe PMC)

PMID3751460 (opens in a new tab)DOI10.1530/acta.0.1120457 (opens in a new tab)PepBankPUB-03751460
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, plasma immunoreactive desmopressin was detected after administration to each tested gastrointestinal region.

    In plain wordsIn rabbits, desmopressin reached plasma after administration to each tested gastrointestinal region.

    Peptide
    Desmopressin
    Outcome
    Not applicableSystemic absorption
    Study

    rabbitn: not reported in source

    Gastrointestinal absorption
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intra-gastrointestinal injectionAs given in this study (rabbit).

    Source sentences

    Summary
    In each case immunoreactive DDAVP could be demonstrated in plasma.
    2 context sentences
    Summary · context
    By using a specific radioimmunoassay for 1-deamino-8-D-arginine vasopressin (DDAVP), plasma concentrations were measured in rabbit plasma at various times after intra-gastrointestinal injections.
    Summary · context
    Five anatomically distinct regions were employed to administer the peptide, namely: the stomach, the duodenum, the mid-part of the ileum, the ileo-coecal junction and the mid-part of the colon.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, desmopressin concentrations were highest after duodenal and ileo-coecal administration.

    In plain wordsIn rabbits, desmopressin concentrations were highest after duodenal and ileo-coecal administration compared with other tested regions.

    Peptide
    Desmopressin
    Outcome
    IncreasePlasma concentrations by administration region
    Study

    rabbitn: not reported in source

    Gastrointestinal absorption
    Comparator
    Other tested gastrointestinal regions
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intra-gastrointestinal injectionAs given in this study (rabbit).

    Source sentences

    Summary
    The highest concentrations were observed after duodenal and ileo-coecal administration.
    2 context sentences
    Summary · context
    By using a specific radioimmunoassay for 1-deamino-8-D-arginine vasopressin (DDAVP), plasma concentrations were measured in rabbit plasma at various times after intra-gastrointestinal injections.
    Summary · context
    Five anatomically distinct regions were employed to administer the peptide, namely: the stomach, the duodenum, the mid-part of the ileum, the ileo-coecal junction and the mid-part of the colon.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, desmopressin peak plasma levels occurred after 10-20 min.

    In plain wordsIn rabbits, desmopressin peak plasma levels occurred after 10-20 min.

    Peptide
    Desmopressin
    Outcome
    Not applicableTime to peak plasma levels
    Study

    rabbitn: not reported in source

    Gastrointestinal absorption
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intra-gastrointestinal injectionAs given in this study (rabbit).

    Source sentences

    Summary
    Absorption was rapid; peak levels were reached after 10-20 min.
    2 context sentences
    Summary · context
    By using a specific radioimmunoassay for 1-deamino-8-D-arginine vasopressin (DDAVP), plasma concentrations were measured in rabbit plasma at various times after intra-gastrointestinal injections.
    Summary · context
    Five anatomically distinct regions were employed to administer the peptide, namely: the stomach, the duodenum, the mid-part of the ileum, the ileo-coecal junction and the mid-part of the colon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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