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Study · Measured the body's own peptide · 1987

1 result

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

Leonard DG, Ziff EB, Greene LA

Molecular and cellular biology1 Sept 1987Cited by 155 (Europe PMC)

PMID3670309 (opens in a new tab)DOI10.1128/mcb.7.9.3156-3167.1987 (opens in a new tab)PepBankPUB-03670309
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In rat PC12 cells, long-term nerve growth factor treatment raised the mRNA that encodes thymosin beta‑4 about 10-fold.

    In plain wordsIn rat cells, nerve growth factor raised the cell's own thymosin beta‑4 messenger RNA about 10-fold.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta 4 mRNA after long-term NGF
    Study

    ratn: not reported in source

    PC12 rat pheochromocytoma cells
    Outcome group
    Gene expression · Nervous system and cognition

    Measurements

    mRNA change
    10-fold
    PC12 cells after NGF

    Source sentences

    Summary
    one mRNA (increased 10-fold) encodes the peptide thymosin beta 4 and a second mRNA (decreased 2-fold) encodes tyrosine hydroxylase.
    1 context sentence
    Summary · context
    Differential screening of cDNA libraries was used to detect and prepare probes for mRNAs that are regulated in PC12 rat pheochromocytoma cells by long-term (2-week) treatment with nerve growth factor (NGF).

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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