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Study · Animal study (in vivo) · rat · 1986

4 results

Role of adrenal androgens in prostate regression in rats treated with an antiandrogen and an LHRH agonist.

Foldesy RG, Vanderhoof MM, Canton LE, Hahn DW

The Prostate1 Jan 1986Cited by 2 (Europe PMC)

PMID3534825 (opens in a new tab)DOI10.1002/pros.2990090303 (opens in a new tab)PepBankPUB-03534825
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In intact rats, histrelin alone decreased prostate weight.

    In plain wordsIn rats, histrelin alone decreased prostate weight.

    Peptide
    Histrelin
    Outcome
    DecreaseProstate weight
    Study

    ratn: not reported in source

    intact rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Each compound, given separately, was effective in decreasing prostate weights in intact rats.
    1 context sentence
    Summary · context
    Histrelin, a potent luteinizing hormone releasing hormone (LHRH) agonist, and flutamide, an antiandrogen, were administered to intact and adrenalectomized rats to determine the role of adrenal androgens in the additive effects of the two drugs on prostate regression.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adrenalectomized rats, adding histrelin to flutamide reduced prostate weight more than flutamide alone.

    In plain wordsIn rats without adrenal glands, histrelin with flutamide reduced prostate weight more than flutamide alone.

    Peptide
    Histrelin
    Outcome
    DecreaseProstate weight with flutamide background
    Study

    ratn: not reported in source

    adrenalectomized rats
    Comparator
    flutamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, in adrenalectomized rats, the combination of histrelin and flutamide still produced a greater reduction in prostate weights than did either drug alone, indicating that the role of adrenal androgens in this effect is negligible.
    1 context sentence
    Summary · context
    Histrelin, a potent luteinizing hormone releasing hormone (LHRH) agonist, and flutamide, an antiandrogen, were administered to intact and adrenalectomized rats to determine the role of adrenal androgens in the additive effects of the two drugs on prostate regression.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In intact rats, histrelin with flutamide produced greater prostate atrophy than flutamide alone.

    In plain wordsIn intact rats, histrelin with flutamide produced greater prostate shrinkage than flutamide alone.

    Peptide
    Histrelin
    Outcome
    DecreaseProstate weight with flutamide background in intact rats
    Study

    ratn: not reported in source

    intact rats
    Comparator
    flutamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When given together, additive effects were demonstrated by even greater atrophy of the prostates.
    2 context sentences
    Summary · context
    Histrelin, a potent luteinizing hormone releasing hormone (LHRH) agonist, and flutamide, an antiandrogen, were administered to intact and adrenalectomized rats to determine the role of adrenal androgens in the additive effects of the two drugs on prostate regression.
    Summary · context
    Each compound, given separately, was effective in decreasing prostate weights in intact rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In castrate, androgen-supplemented rats, histrelin with flutamide did not show the previously observed additive prostate regression.

    In plain wordsIn castrate rats given androgens, histrelin with flutamide did not show the previously observed additional prostate shrinkage.

    Peptide
    Histrelin
    Outcome
    No significant changeAdditive prostate regression in androgen-supplemented castrate rats
    Study

    ratn: not reported in source

    castrate, androgen-supplemented rats
    Comparator
    flutamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This experiment also was repeated with castrate, androgen-supplemented rats, and the additive effects previously described were not observed.
    2 context sentences
    Summary · context
    Histrelin, a potent luteinizing hormone releasing hormone (LHRH) agonist, and flutamide, an antiandrogen, were administered to intact and adrenalectomized rats to determine the role of adrenal androgens in the additive effects of the two drugs on prostate regression.
    Summary · context
    However, in adrenalectomized rats, the combination of histrelin and flutamide still produced a greater reduction in prostate weights than did either drug alone, indicating that the role of adrenal androgens in this effect is negligible.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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