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Study · Animal study (in vivo) · rat · 1986

5 results

Lack of correlation between fertility and sperm numbers in male rats treated with histrelin, a potent LHRH agonist.

Foldesy RG, Vanderhoof MM, Hahn DW

Journal of andrology1 May 1986Cited by 4 (Europe PMC)

PMID3522515 (opens in a new tab)DOI10.1002/j.1939-4640.1986.tb00897.x (opens in a new tab)PepBankPUB-03522515
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats receiving histrelin, serum testosterone decreased significantly by week 2.

    In plain wordsIn rats receiving histrelin, testosterone decreased significantly by week 2.

    Peptide
    Histrelin
    Outcome
    DecreaseSerum testosterone
    Study

    ratn: not reported in source

    Adult male rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · up to 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    Although serum testosterone concentrations and testicular sperm numbers were significantly decreased by weeks 2 and 4 respectively, a reduction in fertility, as judged by the mean number of fetuses per mated female, was not observed until the sixth week of treatment.
    1 context sentence
    Summary · context
    Adult male rats were treated daily for up to 8 weeks with histrelin, [(ImBzl)-D-His6, Pro9-NEt]LHRH, to study the antifertility effects of this LHRH agonist.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats receiving histrelin, testicular sperm numbers decreased significantly by week 4.

    In plain wordsIn rats receiving histrelin, testicular sperm numbers decreased significantly by week 4.

    Peptide
    Histrelin
    Outcome
    DecreaseTesticular sperm numbers
    Study

    ratn: not reported in source

    Adult male rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · up to 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    Although serum testosterone concentrations and testicular sperm numbers were significantly decreased by weeks 2 and 4 respectively, a reduction in fertility, as judged by the mean number of fetuses per mated female, was not observed until the sixth week of treatment.
    1 context sentence
    Summary · context
    Adult male rats were treated daily for up to 8 weeks with histrelin, [(ImBzl)-D-His6, Pro9-NEt]LHRH, to study the antifertility effects of this LHRH agonist.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats receiving histrelin, fertility measured by fetuses per mated female decreased only from the sixth treatment week.

    In plain wordsIn rats receiving histrelin, fertility decreased only from the sixth treatment week.

    Peptide
    Histrelin
    Outcome
    DecreaseFertility
    Study

    ratn: not reported in source

    Adult male rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · up to 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    Although serum testosterone concentrations and testicular sperm numbers were significantly decreased by weeks 2 and 4 respectively, a reduction in fertility, as judged by the mean number of fetuses per mated female, was not observed until the sixth week of treatment.
    1 context sentence
    Summary · context
    Adult male rats were treated daily for up to 8 weeks with histrelin, [(ImBzl)-D-His6, Pro9-NEt]LHRH, to study the antifertility effects of this LHRH agonist.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats receiving histrelin, cauda epididymal sperm numbers never fell below initial control levels during the study.

    In plain wordsIn rats receiving histrelin, epididymal sperm numbers never fell below initial control levels.

    Peptide
    Histrelin
    Outcome
    Not applicableCauda epididymal sperm numbers
    Study

    ratn: not reported in source

    Adult male rats
    Comparator
    Initial control levels
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · up to 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, the number of spermatozoa in the cauda epididymidis of treated rats did not decrease below initial control levels at any time during the study and full fertility returned within 4 weeks after histrelin treatment was stopped.
    1 context sentence
    Summary · context
    Adult male rats were treated daily for up to 8 weeks with histrelin, [(ImBzl)-D-His6, Pro9-NEt]LHRH, to study the antifertility effects of this LHRH agonist.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, full fertility returned within 4 weeks after histrelin treatment stopped.

    In plain wordsIn rats, full fertility returned within 4 weeks after histrelin treatment stopped.

    Peptide
    Histrelin
    Outcome
    IncreaseFertility recovery
    Study

    ratn: not reported in source

    Adult male rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · up to 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, the number of spermatozoa in the cauda epididymidis of treated rats did not decrease below initial control levels at any time during the study and full fertility returned within 4 weeks after histrelin treatment was stopped.
    1 context sentence
    Summary · context
    Adult male rats were treated daily for up to 8 weeks with histrelin, [(ImBzl)-D-His6, Pro9-NEt]LHRH, to study the antifertility effects of this LHRH agonist.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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