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Study · Randomized controlled trial · n = 30 · 1987

11 results

Comparison of intranasal and oral desmopressin for nocturnal enuresis.

Fjellestad-Paulsen A, Wille S, Harris AS

Archives of disease in childhood1 Jul 1987Cited by 46 (Europe PMC)

PMID3307643 (opens in a new tab)PMCIDPMC1779260 (opens in a new tab)DOI10.1136/adc.62.7.674 (opens in a new tab)PepBankPUB-03307643
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In children with nocturnal enuresis, oral desmopressin produced significantly more dry nights than placebo.

    In plain wordsIn children with nocturnal enuresis, oral desmopressin increased dry nights compared with placebo.

    Peptide
    Desmopressin
    Outcome
    IncreaseDry nights
    Study

    n = 30

    Comparator
    Placebo
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    200 micrograms · oralAs given in this study (human).

    Source sentences

    Summary
    The numbers of dry nights were significantly greater during both periods of treatment with desmopressin when compared with that using placebo, but there were no differences between the methods of taking the drug.
    1 context sentence
    Summary · context
    A randomised, double blind, double dummy, cross over study was then carried out in 30 children to compare the effects of a 20 micrograms dose given through a nasal pipette, a 200 micrograms tablet, and a placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In children with nocturnal enuresis, nasal desmopressin produced significantly more dry nights than placebo.

    In plain wordsIn children with nocturnal enuresis, nasal desmopressin increased dry nights compared with placebo.

    Peptide
    Desmopressin
    Outcome
    IncreaseDry nights
    Study

    n = 30

    Comparator
    Placebo
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    20 micrograms · intranasalAs given in this study (human).

    Source sentences

    Summary
    The numbers of dry nights were significantly greater during both periods of treatment with desmopressin when compared with that using placebo, but there were no differences between the methods of taking the drug.
    1 context sentence
    Summary · context
    A randomised, double blind, double dummy, cross over study was then carried out in 30 children to compare the effects of a 20 micrograms dose given through a nasal pipette, a 200 micrograms tablet, and a placebo.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In children with nocturnal enuresis, dry nights did not differ between oral and nasal desmopressin.

    In plain wordsIn children with nocturnal enuresis, dry nights did not differ between oral and nasal desmopressin.

    Peptide
    Desmopressin
    Outcome
    No significant changeDry nights by route
    Study

    n = 30

    Comparator
    Oral versus nasal desmopressin
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    20 micrograms nasal; 200 micrograms tablet · intranasal and oralAs given in this study (human).

    Source sentences

    Summary
    The numbers of dry nights were significantly greater during both periods of treatment with desmopressin when compared with that using placebo, but there were no differences between the methods of taking the drug.
    1 context sentence
    Summary · context
    A randomised, double blind, double dummy, cross over study was then carried out in 30 children to compare the effects of a 20 micrograms dose given through a nasal pipette, a 200 micrograms tablet, and a placebo.
  4. 04HumanNon-randomized trialEfficacy outcome

    In children with nocturnal enuresis, oral desmopressin 100 micrograms produced significantly more dry nights than placebo.

    In plain wordsIn children with nocturnal enuresis, oral desmopressin 100 micrograms increased dry nights compared with placebo.

    Peptide
    Desmopressin
    Outcome
    IncreaseDry nights
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    100 micrograms · oralAs given in this study (human).

    Source sentences

    Summary
    A dose response effect was seen, with the 100, 200, and 400 micrograms doses resulting in significantly more dry nights than when a placebo was used.
    1 context sentence
    Summary · context
    A single blind dose response study of the effects of treatment with tablets containing 50-400 micrograms of desmopressin was conducted in 15 children with primary nocturnal enuresis.
  5. 05HumanNon-randomized trialEfficacy outcome

    In children with nocturnal enuresis, oral desmopressin 200 micrograms produced significantly more dry nights than placebo.

    In plain wordsIn children with nocturnal enuresis, oral desmopressin 200 micrograms increased dry nights compared with placebo.

    Peptide
    Desmopressin
    Outcome
    IncreaseDry nights
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    200 micrograms · oralAs given in this study (human).

    Source sentences

    Summary
    A dose response effect was seen, with the 100, 200, and 400 micrograms doses resulting in significantly more dry nights than when a placebo was used.
    1 context sentence
    Summary · context
    A single blind dose response study of the effects of treatment with tablets containing 50-400 micrograms of desmopressin was conducted in 15 children with primary nocturnal enuresis.
  6. 06HumanNon-randomized trialEfficacy outcome

    In children with nocturnal enuresis, oral desmopressin 400 micrograms produced significantly more dry nights than placebo.

    In plain wordsIn children with nocturnal enuresis, oral desmopressin 400 micrograms increased dry nights compared with placebo.

    Peptide
    Desmopressin
    Outcome
    IncreaseDry nights
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    400 micrograms · oralAs given in this study (human).

    Source sentences

    Summary
    A dose response effect was seen, with the 100, 200, and 400 micrograms doses resulting in significantly more dry nights than when a placebo was used.
    1 context sentence
    Summary · context
    A single blind dose response study of the effects of treatment with tablets containing 50-400 micrograms of desmopressin was conducted in 15 children with primary nocturnal enuresis.
  7. 07HumanNon-randomized trialEfficacy outcome

    In children with nocturnal enuresis, the response to 200 micrograms differed significantly from 100 micrograms (p less than 0.02).

    In plain wordsIn children with nocturnal enuresis, response differed significantly between oral desmopressin 200 and 100 micrograms.

    Peptide
    Desmopressin
    Outcome
    Direction not reportedDry-night response versus 100 micrograms
    Study

    n = 15

    Comparator
    100 micrograms oral desmopressin
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    200 micrograms · oralAs given in this study (human).

    Source sentences

    Summary
    The response after 200 micrograms was significantly different from that after 100 micrograms (p less than 0.02) but not from that after 400 micrograms.
    2 context sentences
    Summary · context
    A dose response effect was seen, with the 100, 200, and 400 micrograms doses resulting in significantly more dry nights than when a placebo was used.
    Summary · context
    A single blind dose response study of the effects of treatment with tablets containing 50-400 micrograms of desmopressin was conducted in 15 children with primary nocturnal enuresis.
  8. 08HumanNon-randomized trialEfficacy outcome

    In children with nocturnal enuresis, responses to oral desmopressin 200 and 400 micrograms did not differ significantly.

    In plain wordsIn children with nocturnal enuresis, response did not differ significantly between oral desmopressin 200 and 400 micrograms.

    Peptide
    Desmopressin
    Outcome
    No significant changeDry-night response versus 400 micrograms
    Study

    n = 15

    Comparator
    400 micrograms oral desmopressin
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    200 micrograms · oralAs given in this study (human).

    Source sentences

    Summary
    The response after 200 micrograms was significantly different from that after 100 micrograms (p less than 0.02) but not from that after 400 micrograms.
    1 context sentence
    Summary · context
    A single blind dose response study of the effects of treatment with tablets containing 50-400 micrograms of desmopressin was conducted in 15 children with primary nocturnal enuresis.
  9. 09HumanNon-randomized trialEfficacy outcome

    In children with nocturnal enuresis, 41% improved by more than 50% after oral desmopressin.

    In plain wordsIn children with nocturnal enuresis, 41% improved by more than 50% after oral desmopressin.

    Peptide
    Desmopressin
    Outcome
    Not applicableImprovement greater than 50%
    Study

    n: not reported in source

    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    200 micrograms · oralAs given in this study (human).

    Measurements

    Patients improved by more than 50%
    41%
    oral desmopressin

    Source sentences

    Summary
    After oral and nasal treatment 41% and 52%, respectively, of the patients improved by more than 50%.
    1 context sentence
    Summary · context
    A randomised, double blind, double dummy, cross over study was then carried out in 30 children to compare the effects of a 20 micrograms dose given through a nasal pipette, a 200 micrograms tablet, and a placebo.
  10. 10HumanNon-randomized trialEfficacy outcome

    In children with nocturnal enuresis, 52% improved by more than 50% after nasal desmopressin.

    In plain wordsIn children with nocturnal enuresis, 52% improved by more than 50% after nasal desmopressin.

    Peptide
    Desmopressin
    Outcome
    Not applicableImprovement greater than 50%
    Study

    n: not reported in source

    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    20 micrograms · intranasalAs given in this study (human).

    Measurements

    Patients improved by more than 50%
    52%
    nasal desmopressin

    Source sentences

    Summary
    After oral and nasal treatment 41% and 52%, respectively, of the patients improved by more than 50%.
    1 context sentence
    Summary · context
    A randomised, double blind, double dummy, cross over study was then carried out in 30 children to compare the effects of a 20 micrograms dose given through a nasal pipette, a 200 micrograms tablet, and a placebo.
  11. 11HumanNon-randomized trialEfficacy outcome

    In children with nocturnal enuresis, nine children (31%) remained completely dry after treatment.

    In plain wordsIn children with nocturnal enuresis, nine children (31%) remained completely dry after treatment.

    Peptide
    Desmopressin
    Outcome
    Not applicableComplete dryness after treatment
    Study

    n: not reported in source

    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    Dose not stated

    Measurements

    Children completely dry after treatment
    9 children
    after treatment
    Children completely dry after treatment
    31%
    after treatment

    Source sentences

    Summary
    Nine children (31%) remained completely dry after treatment.
    1 context sentence
    Summary · context
    A randomised, double blind, double dummy, cross over study was then carried out in 30 children to compare the effects of a 20 micrograms dose given through a nasal pipette, a 200 micrograms tablet, and a placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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