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Study · Measured the body's own peptide · 1988

2 results

Defective in vitro gamma interferon production and elevated serum immunoreactive thymosin beta 4 levels in patients with inflammatory bowel disease.

Mutchnick MG, Lee HH, Hollander DI, Haynes GD, Chua DC

Clinical immunology and immunopathology1 Apr 1988Cited by 19 (Europe PMC)

PMID3127096 (opens in a new tab)DOI10.1016/0090-1229(88)90147-x (opens in a new tab)PepBankPUB-03127096
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    Serum levels of the body's own thymosin alpha‑1 were comparable in patients with Crohn's disease, ulcerative colitis, disease controls and healthy controls.

    In plain wordsNatural thymosin alpha‑1 levels in blood were similar in patients with bowel disease and in healthy people.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeSerum thymosin alpha 1 level
    Study

    n: not reported in source

    Comparator
    Healthy controls and disease controls
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Serum thymosin alpha 1 levels were comparable in all study groups
    1 context sentence
    Summary · context
    Gamma interferon (IFN-gamma) production by peripheral blood mononuclear cells (PBM) was measured in 21 patients with Crohn's disease, in 15 patients with ulcerative colitis, in 12 patients with non-IBD gastrointestinal disease (disease control), and in 28 healthy controls.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In patients with Crohn's disease or ulcerative colitis, serum thymosin beta‑4 concentrations were significantly higher than in healthy controls.

    In plain wordsIn people with bowel disease, the body's own thymosin beta‑4 in blood was higher than in healthy controls.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSerum thymosin beta 4 in inflammatory bowel disease
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    serum thymosin beta 4 concentrations were significantly higher in all patient groups than in the healthy controls.
    2 context sentences
    Summary · context
    Gamma interferon (IFN-gamma) production by peripheral blood mononuclear cells (PBM) was measured in 21 patients with Crohn's disease, in 15 patients with ulcerative colitis, in 12 patients with non-IBD gastrointestinal disease (disease control), and in 28 healthy controls.
    Summary · context
    T-cell subset proportions and serum levels of thymosin alpha 1 and thymosin beta 4, two hormonelike thymic peptides, were also determined.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    12 Oct 2026, 18:17 UTC

    Study data updated · source update from Europe PMC

  2. Version 3

    10 Oct 2026, 08:55 UTC

    Study results updated

  3. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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