Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo.

Sonntag WE, Goliszek AG, Brodish A, Eldridge JC

Endocrinology1 Jun 1987Cited by 70 (Europe PMC)

PMID3032584DOI10.1210/endo-120-6-2308PepBankPUB-03032584

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In young rats, corticosterone after ACTHAR administration was significantly greater at 1700 h than at 1100 h.
In plain wordsIn young rats, ACTHAR produced higher corticosterone levels at 1700 h than at 1100 h.
Peptide
ACTH (corticotropin)
Outcome
IncreaseCorticosterone response by administration time in young rats
Study
ratn: not reported in source
Dexamethasone-pretreated Fischer 344 male rats
Comparator
ACTHAR administration at 1100 h
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 mIU/kg · intravenousAs given in this study (rat).
Measurements
P value
< 0.05
1700 h versus 1100 h
Source sentences
Summary
Plasma corticosterone levels were significantly greater after ACTH administration (1 mIU/kg ACTHAR, iv) at 1700 h in both young and old rats compared to 1100 h values (P less than 0.05),
1 context sentence(design, population, supporting numbers)
Summary · context
Age-related changes in the sensitivity of the adrenal gland to a submaximal dose of ACTH were tested in dexamethasone-pretreated animals at 1100 and 1700 h in a separate experiment.
Report a problemFND-0303258401
02AnimalAnimal study (in vivo)Activity measurement
In old rats, corticosterone after ACTHAR administration was significantly greater at 1700 h than at 1100 h.
In plain wordsIn old rats, ACTHAR produced higher corticosterone levels at 1700 h than at 1100 h.
Peptide
ACTH (corticotropin)
Outcome
IncreaseCorticosterone response by administration time in old rats
Study
ratn: not reported in source
Dexamethasone-pretreated Fischer 344 male rats
Comparator
ACTHAR administration at 1100 h
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 mIU/kg · intravenousAs given in this study (rat).
Measurements
P value
< 0.05
1700 h versus 1100 h
Source sentences
Summary
Plasma corticosterone levels were significantly greater after ACTH administration (1 mIU/kg ACTHAR, iv) at 1700 h in both young and old rats compared to 1100 h values (P less than 0.05),
1 context sentence(design, population, supporting numbers)
Summary · context
Age-related changes in the sensitivity of the adrenal gland to a submaximal dose of ACTH were tested in dexamethasone-pretreated animals at 1100 and 1700 h in a separate experiment.
Report a problemFND-0303258402
03AnimalAnimal study (in vivo)Activity measurement
In old rats, corticosterone 20 min after ACTHAR at 1700 h was significantly greater than in young rats.
In plain wordsIn old rats, corticosterone after ACTHAR at 1700 h was higher than in young rats.
Peptide
ACTH (corticotropin)
Outcome
IncreaseCorticosterone response in old versus young rats
Study
ratn: not reported in source
Dexamethasone-pretreated Fischer 344 male rats
Comparator
Young rats given ACTHAR at 1700 h
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 mIU/kg · intravenousAs given in this study (rat).
Measurements
Post-injection time
20 min
1700 h ACTHAR
P value
< 0.05
old versus young rats
Source sentences
Summary
and levels 20 min post-ACTH injection at 1700 h were significantly greater in old than young or middle-aged rats at the same time (P less than 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Plasma corticosterone levels were significantly greater after ACTH administration (1 mIU/kg ACTHAR, iv) at 1700 h in both young and old rats compared to 1100 h values (P less than 0.05),
Summary · context
Age-related changes in the sensitivity of the adrenal gland to a submaximal dose of ACTH were tested in dexamethasone-pretreated animals at 1100 and 1700 h in a separate experiment.
Report a problemFND-0303258403
04AnimalAnimal study (in vivo)Activity measurement
In old rats, corticosterone 20 min after ACTHAR at 1700 h was significantly greater than in middle-aged rats.
In plain wordsIn old rats, corticosterone after ACTHAR at 1700 h was higher than in middle-aged rats.
Peptide
ACTH (corticotropin)
Outcome
IncreaseCorticosterone response in old versus middle-aged rats
Study
ratn: not reported in source
Dexamethasone-pretreated Fischer 344 male rats
Comparator
Middle-aged rats given ACTHAR at 1700 h
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 mIU/kg · intravenousAs given in this study (rat).
Measurements
Post-injection time
20 min
1700 h ACTHAR
P value
< 0.05
old versus middle-aged rats
Source sentences
Summary
and levels 20 min post-ACTH injection at 1700 h were significantly greater in old than young or middle-aged rats at the same time (P less than 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Plasma corticosterone levels were significantly greater after ACTH administration (1 mIU/kg ACTHAR, iv) at 1700 h in both young and old rats compared to 1100 h values (P less than 0.05),
Summary · context
Age-related changes in the sensitivity of the adrenal gland to a submaximal dose of ACTH were tested in dexamethasone-pretreated animals at 1100 and 1700 h in a separate experiment.
Report a problemFND-0303258404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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