Glucagon stimulation of brown adipose tissue growth and thermogenesis.

Billington CJ, Bartness TJ, Briggs J, Levine AS, Morley JE

The American journal of physiology1 Jan 1987Cited by 65 (Europe PMC)

PMID3028165DOI10.1152/ajpregu.1987.252.1.r160PepBankPUB-03028165

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, glucagon decreased feed efficiency compared with saline-injected controls.
In plain wordsIn rats, glucagon decreased feed efficiency compared with saline-injected controls.
Peptide
Glucagon
Outcome
DecreaseFeed efficiency
Study
ratn: not reported in source
Male Sprague-Dawley rats
Comparator
Saline-injected controls
Outcome group
Body weight · Metabolic and weight
Studied dose
1 mg/kg · injection · 18 daysAs given in this study (rat).
Source sentences
Summary
Eighteen days of glucagon injections (1 mg/kg) to male Sprague-Dawley rats produced, relative to saline-injected controls, decreases in feed efficiency and increases in brown adipose tissue weight, protein content, DNA content, and mitochondrial mass as reflected in cytochrome oxidase activity.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816501
02AnimalAnimal study (in vivo)Mechanism
In rats, glucagon increased brown adipose tissue weight compared with saline-injected controls.
In plain wordsIn rats, glucagon increased brown fat weight compared with saline-injected controls.
Peptide
Glucagon
Outcome
IncreaseBrown adipose tissue weight
Study
ratn: not reported in source
Male Sprague-Dawley rats
Comparator
Saline-injected controls
Outcome group
Body composition · Metabolic and weight
Studied dose
1 mg/kg · injection · 18 daysAs given in this study (rat).
Source sentences
Summary
Eighteen days of glucagon injections (1 mg/kg) to male Sprague-Dawley rats produced, relative to saline-injected controls, decreases in feed efficiency and increases in brown adipose tissue weight, protein content, DNA content, and mitochondrial mass as reflected in cytochrome oxidase activity.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816502
03AnimalAnimal study (in vivo)Mechanism
In rats, glucagon increased brown adipose protein content compared with saline-injected controls.
In plain wordsIn rats, glucagon increased brown fat protein content compared with saline-injected controls.
Peptide
Glucagon
Outcome
IncreaseBrown adipose protein content
Study
ratn: not reported in source
Male Sprague-Dawley rats
Comparator
Saline-injected controls
Outcome group
Body composition · Metabolic and weight
Studied dose
1 mg/kg · injection · 18 daysAs given in this study (rat).
Source sentences
Summary
Eighteen days of glucagon injections (1 mg/kg) to male Sprague-Dawley rats produced, relative to saline-injected controls, decreases in feed efficiency and increases in brown adipose tissue weight, protein content, DNA content, and mitochondrial mass as reflected in cytochrome oxidase activity.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816503
04AnimalAnimal study (in vivo)Mechanism
In rats, glucagon increased brown adipose DNA content compared with saline-injected controls.
In plain wordsIn rats, glucagon increased brown fat DNA content compared with saline-injected controls.
Peptide
Glucagon
Outcome
IncreaseBrown adipose DNA content
Study
ratn: not reported in source
Male Sprague-Dawley rats
Comparator
Saline-injected controls
Outcome group
Body composition · Metabolic and weight
Studied dose
1 mg/kg · injection · 18 daysAs given in this study (rat).
Source sentences
Summary
Eighteen days of glucagon injections (1 mg/kg) to male Sprague-Dawley rats produced, relative to saline-injected controls, decreases in feed efficiency and increases in brown adipose tissue weight, protein content, DNA content, and mitochondrial mass as reflected in cytochrome oxidase activity.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816504
05AnimalAnimal study (in vivo)Mechanism
In rats, glucagon increased brown adipose mitochondrial mass, reflected by cytochrome oxidase activity, compared with saline-injected controls.
In plain wordsIn rats, glucagon increased brown fat mitochondrial mass compared with saline-injected controls, as indicated by enzyme activity.
Peptide
Glucagon
Outcome
IncreaseMitochondrial mass reflected by cytochrome oxidase
Study
ratn: not reported in source
Male Sprague-Dawley rats
Comparator
Saline-injected controls
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
1 mg/kg · injection · 18 daysAs given in this study (rat).
Source sentences
Summary
Eighteen days of glucagon injections (1 mg/kg) to male Sprague-Dawley rats produced, relative to saline-injected controls, decreases in feed efficiency and increases in brown adipose tissue weight, protein content, DNA content, and mitochondrial mass as reflected in cytochrome oxidase activity.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816505
06AnimalAnimal study (in vivo)Mechanism
In rats, glucagon produced similar but smaller brown adipose changes than norepinephrine.
In plain wordsIn rats, glucagon produced similar but smaller brown fat changes than norepinephrine.
Peptide
Glucagon
Outcome
DecreaseMagnitude of brown adipose response
Study
ratn: not reported in source
Male Sprague-Dawley rats
Comparator
Norepinephrine 250 micrograms/kg
Outcome group
Body composition · Metabolic and weight
Studied dose
1 mg/kg · injection · 18 daysAs given in this study (rat).
Source sentences
Summary
The observed changes were similar, though of lesser magnitude, to changes produced in these same parameters induced by administration of norepinephrine (250 micrograms/kg) for a positive control group.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighteen days of glucagon injections (1 mg/kg) to male Sprague-Dawley rats produced, relative to saline-injected controls, decreases in feed efficiency and increases in brown adipose tissue weight, protein content, DNA content, and mitochondrial mass as reflected in cytochrome oxidase activity.
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816506
07AnimalAnimal study (in vivo)Mechanism
In rats, glucagon increased specific cytochrome oxidase activity after 4 days.
In plain wordsIn rats, glucagon increased specific cytochrome oxidase activity after 4 days.
Peptide
Glucagon
Outcome
IncreaseSpecific cytochrome oxidase activity
Study
ratn: not reported in source
Male Sprague-Dawley rats
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
1 mg/kg · injection · 4 daysAs given in this study (rat).
Source sentences
Summary
Four days of glucagon administration (1 mg/kg) produced increases in specific activity of cytochrome oxidase and lipoprotein lipase.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816507
08AnimalAnimal study (in vivo)Mechanism
In rats, glucagon increased specific lipoprotein lipase activity after 4 days.
In plain wordsIn rats, glucagon increased specific lipoprotein lipase activity after 4 days.
Peptide
Glucagon
Outcome
IncreaseSpecific lipoprotein lipase activity
Study
ratn: not reported in source
Male Sprague-Dawley rats
Outcome group
Lipids · Metabolic and weight
Studied dose
1 mg/kg · injection · 4 daysAs given in this study (rat).
Source sentences
Summary
Four days of glucagon administration (1 mg/kg) produced increases in specific activity of cytochrome oxidase and lipoprotein lipase.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816508
09AnimalAnimal study (in vivo)Mechanism
In rats, whole-pad activity changes after 8 days of glucagon resembled those after 18 days.
In plain wordsIn rats, whole-pad activity changes after 8 days of glucagon resembled those after 18 days.
Peptide
Glucagon
Outcome
Not applicableWhole-pad activity at 8 days
Study
ratn: not reported in source
Male Sprague-Dawley rats
Comparator
18 days of glucagon administration
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
1 mg/kg · injection · 8 daysAs given in this study (rat).
Source sentences
Summary
After 8 days of glucagon administration, changes in whole-pad activity similar to those seen with 18 days of administration were present.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816509
10AnimalAnimal study (in vivo)Mechanism
In rats, glucagon increased whole-pad lipoprotein lipase activity after 4 days.
In plain wordsIn rats, glucagon increased whole-pad lipoprotein lipase activity after 4 days.
Peptide
Glucagon
Outcome
IncreaseWhole-pad lipoprotein lipase activity at 4 days
Study
ratn: not reported in source
Male Sprague-Dawley rats
Outcome group
Lipids · Metabolic and weight
Studied dose
1 mg/kg · injection · 4 daysAs given in this study (rat).
Source sentences
Summary
Glucagon also increased whole-pad lipoprotein lipase activity after 4 and 8 days.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816510
11AnimalAnimal study (in vivo)Mechanism
In rats, glucagon increased whole-pad lipoprotein lipase activity after 8 days.
In plain wordsIn rats, glucagon increased whole-pad lipoprotein lipase activity after 8 days.
Peptide
Glucagon
Outcome
IncreaseWhole-pad lipoprotein lipase activity at 8 days
Study
ratn: not reported in source
Male Sprague-Dawley rats
Outcome group
Lipids · Metabolic and weight
Studied dose
1 mg/kg · injection · 8 daysAs given in this study (rat).
Source sentences
Summary
Glucagon also increased whole-pad lipoprotein lipase activity after 4 and 8 days.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816511
12AnimalAnimal study (in vivo)Mechanism
In rats, denervated interscapular brown adipose tissue retained a diminished response to glucagon.
In plain wordsIn rats, brown fat with surgically removed nerve input retained a diminished response to glucagon.
Peptide
Glucagon
Outcome
MixedResponse after surgical denervation
Study
ratn: not reported in source
Male Sprague-Dawley rats
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
1 mg/kg · injectionAs given in this study (rat).
Source sentences
Summary
Surgically denervated interscapular brown adipose tissue retained its ability to respond to exogenous glucagon, though the magnitude of the response was diminished.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816512
13AnimalAnimal study (in vivo)Mechanism
In rats, glucagon increased mitochondrial GDP binding per milligram protein compared with controls.
In plain wordsIn rats, glucagon increased mitochondrial GDP binding per milligram protein compared with controls.
Peptide
Glucagon
Outcome
IncreaseGDP binding per mitochondrial protein
Study
ratn: not reported in source
Male Sprague-Dawley rats
Comparator
Controls
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
1 mg/kg · injection · 5 daysAs given in this study (rat).
Source sentences
Summary
There was an increase in GDP binding relative to controls whether expressed as picomoles per milligram mitochondrial protein or nanomoles per pad.(ABSTRACT TRUNCATED AT 250 WORDS)
2 context sentences(design, population, supporting numbers)
Summary · context
Guanosine 5'-diphosphate (GDP) binding to brown adipose tissue mitochondria was measured as an assessment of functional state after 5 days of glucagon (1 mg/kg).
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816513
14AnimalAnimal study (in vivo)Mechanism
In rats, glucagon increased mitochondrial GDP binding per pad compared with controls.
In plain wordsIn rats, glucagon increased mitochondrial GDP binding per brown fat pad compared with controls.
Peptide
Glucagon
Outcome
IncreaseGDP binding per brown adipose pad
Study
ratn: not reported in source
Male Sprague-Dawley rats
Comparator
Controls
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
1 mg/kg · injection · 5 daysAs given in this study (rat).
Source sentences
Summary
There was an increase in GDP binding relative to controls whether expressed as picomoles per milligram mitochondrial protein or nanomoles per pad.(ABSTRACT TRUNCATED AT 250 WORDS)
2 context sentences(design, population, supporting numbers)
Summary · context
Guanosine 5'-diphosphate (GDP) binding to brown adipose tissue mitochondria was measured as an assessment of functional state after 5 days of glucagon (1 mg/kg).
Summary · context
We investigated the ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding.
Report a problemFND-0302816514

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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