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Study · Non-randomized trial · n = 20 · 1986

6 results

Responses to glucagon infusion in pseudohypoparathyroidism.

Brickman AS, Carlson HE, Levin SR

The Journal of clinical endocrinology and metabolism1 Dec 1986Cited by 17 (Europe PMC)

PMID3023420 (opens in a new tab)DOI10.1210/jcem-63-6-1354 (opens in a new tab)PepBankPUB-03023420
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanNon-randomized trialMechanism

    In patients with PsHP type Ib, glucose responses to glucagon were normal.

    In plain wordsIn patients with PsHP type Ib, glucagon produced blood glucose responses comparable to those in normal subjects.

    Peptide
    Glucagon
    Outcome
    No significant changeGlucose response in PsHP Ib
    Study

    n = 20

    Comparator
    Normal subjects
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.25-15 micrograms/kg · infusionAs given in this study (human).

    Source sentences

    Summary
    Glucose responses to glucagon were normal in both PsHP groups; the glucose response per unit cAMP response was slightly, but not significantly, enhanced in PsHP type Ia patients.
    3 context sentences
    Summary · context
    Single or graded doses of glucagon (Eli Lilly) were given to patients with pseudohypoparathyroidism (PsHP) type I to examine the possible presence of hormone resistance.
    Summary · context
    The doses of glucagon ranged from 0.25-15 micrograms/kg.
    Summary · context
    The following individuals were studied: 13 normal subjects, 5 patients with low erythrocyte N-protein activity (PsHP type Ia), and 7 patients with normal erythrocyte N-protein activity (PsHP type Ib).
  2. 02HumanNon-randomized trialMechanism

    In PsHP type Ia patients, glucose response per unit cAMP response to glucagon was slightly, but not significantly, enhanced.

    In plain wordsIn PsHP type Ia patients, glucose response per cAMP response after glucagon was slightly higher than normal, without statistical significance.

    Peptide
    Glucagon
    Outcome
    No significant changeGlucose response per cAMP response in PsHP Ia
    Study

    n = 18

    Comparator
    Normal subjects
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.25-15 micrograms/kg · infusionAs given in this study (human).

    Source sentences

    Summary
    Glucose responses to glucagon were normal in both PsHP groups; the glucose response per unit cAMP response was slightly, but not significantly, enhanced in PsHP type Ia patients.
    3 context sentences
    Summary · context
    Single or graded doses of glucagon (Eli Lilly) were given to patients with pseudohypoparathyroidism (PsHP) type I to examine the possible presence of hormone resistance.
    Summary · context
    The doses of glucagon ranged from 0.25-15 micrograms/kg.
    Summary · context
    The following individuals were studied: 13 normal subjects, 5 patients with low erythrocyte N-protein activity (PsHP type Ia), and 7 patients with normal erythrocyte N-protein activity (PsHP type Ib).
  3. 03HumanNon-randomized trialMechanism

    In patients with PsHP type Ia, plasma cAMP responses to all glucagon doses were blunted compared with normal subjects.

    In plain wordsIn patients with PsHP type Ia, cAMP responses to all glucagon doses were lower than in normal subjects.

    Peptide
    Glucagon
    Outcome
    DecreasePlasma cAMP response in PsHP Ia
    Study

    n: not reported in source

    Comparator
    Normal subjects
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.25-15 micrograms/kg · infusionAs given in this study (human).

    Source sentences

    Summary
    The patients with PsHP type Ia had blunted plasma cAMP responses to all glucagon doses.
    3 context sentences
    Summary · context
    Single or graded doses of glucagon (Eli Lilly) were given to patients with pseudohypoparathyroidism (PsHP) type I to examine the possible presence of hormone resistance.
    Summary · context
    The doses of glucagon ranged from 0.25-15 micrograms/kg.
    Summary · context
    The following individuals were studied: 13 normal subjects, 5 patients with low erythrocyte N-protein activity (PsHP type Ia), and 7 patients with normal erythrocyte N-protein activity (PsHP type Ib).
  4. 04HumanNon-randomized trialMechanism

    In patients with PsHP type Ib, cAMP responses to glucagon infusion were normal.

    In plain wordsIn patients with PsHP type Ib, glucagon produced cAMP responses comparable to those in normal subjects.

    Peptide
    Glucagon
    Outcome
    No significant changePlasma cAMP response in PsHP Ib
    Study

    n: not reported in source

    Comparator
    Normal subjects
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.25-15 micrograms/kg · infusionAs given in this study (human).

    Source sentences

    Summary
    In contrast, the patients with PsHP type Ib had normal cAMP responses to glucagon infusion.
    3 context sentences
    Summary · context
    Single or graded doses of glucagon (Eli Lilly) were given to patients with pseudohypoparathyroidism (PsHP) type I to examine the possible presence of hormone resistance.
    Summary · context
    The doses of glucagon ranged from 0.25-15 micrograms/kg.
    Summary · context
    The following individuals were studied: 13 normal subjects, 5 patients with low erythrocyte N-protein activity (PsHP type Ia), and 7 patients with normal erythrocyte N-protein activity (PsHP type Ib).
  5. 05HumanNon-randomized trialMechanism

    In two treated hypothyroid relatives of a PsHP type Ib patient, glucagon cAMP responses were decreased.

    In plain wordsIn two treated hypothyroid relatives of a PsHP type Ib patient, glucagon produced lower cAMP responses than in normal subjects.

    Peptide
    Glucagon
    Outcome
    DecreasePlasma cAMP response in hypothyroid relatives
    Study

    n: not reported in source

    Comparator
    Normal subjects
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.25-15 micrograms/kg · infusionAs given in this study (human).

    Source sentences

    Summary
    However, the 2 relatives of the patient with PsHP type Ib had clearly decreased cAMP responses to glucagon infusion; both had normal renal responses to PTH and were clinically and biochemically euthyroid at the time of study.
    4 context sentences
    Summary · context
    Two additional patients with treated primary hypothyroidism who were relatives of a patient with PsHP type Ib were also studied.
    Summary · context
    Single or graded doses of glucagon (Eli Lilly) were given to patients with pseudohypoparathyroidism (PsHP) type I to examine the possible presence of hormone resistance.
    Summary · context
    The doses of glucagon ranged from 0.25-15 micrograms/kg.
    Summary · context
    The following individuals were studied: 13 normal subjects, 5 patients with low erythrocyte N-protein activity (PsHP type Ia), and 7 patients with normal erythrocyte N-protein activity (PsHP type Ib).
  6. 06HumanNon-randomized trialMechanism

    In patients with PsHP type Ia, glucose responses to glucagon were normal.

    In plain wordsIn patients with PsHP type Ia, glucagon produced blood glucose responses comparable to those in normal subjects.

    Peptide
    Glucagon
    Outcome
    No significant changeGlucose response in PsHP Ia
    Study

    n: not reported in source

    Comparator
    Normal subjects
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.25-15 micrograms/kg · infusionAs given in this study (human).

    Source sentences

    Summary
    Glucose responses to glucagon were normal in both PsHP groups; the glucose response per unit cAMP response was slightly, but not significantly, enhanced in PsHP type Ia patients.
    3 context sentences
    Summary · context
    Single or graded doses of glucagon (Eli Lilly) were given to patients with pseudohypoparathyroidism (PsHP) type I to examine the possible presence of hormone resistance.
    Summary · context
    The doses of glucagon ranged from 0.25-15 micrograms/kg.
    Summary · context
    The following individuals were studied: 13 normal subjects, 5 patients with low erythrocyte N-protein activity (PsHP type Ia), and 7 patients with normal erythrocyte N-protein activity (PsHP type Ib).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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