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Study · Measured the body's own peptide · 1985

4 results

Modulation of thymosin beta 4 by estrogen.

Suh BY, Naylor PH, Goldstein AL, Rebar RW

American journal of obstetrics and gynecology1 Feb 1985Cited by 19 (Europe PMC)

PMID2983555 (opens in a new tab)DOI10.1016/0002-9378(85)90286-8 (opens in a new tab)PepBankPUB-02983555
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In women in various clinical states, basal thymosin alpha‑1 concentrations were similar in all women sampled, and the data suggest that estrogens do not modulate circulating thymosin alpha‑1.

    In plain wordsIn women, the body's own thymosin alpha‑1 levels were similar across groups, which suggests they are not linked to estrogen status.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeBasal serum thymosin alpha 1 across clinical states and estrogen status
    Study

    n = 87

    Outcome group
    Immune response · Endocrine and hormones

    Source sentences

    Summary
    Basal concentrations of thymosin alpha 1 were similar in all women sampled.
    2 context sentences
    Summary · context
    These data suggest that estrogens can modulate the circulating levels of thymosin beta 4 but not of thymosin alpha 1.
    Summary · context
    To determine whether steroid hormones modulate secretion of thymic peptides, basal concentrations of thymosins alpha 1 and beta 4 were determined by radioimmunoassay in morning blood samples from 87 women in various clinical states.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Basal thymosin beta‑4 levels were similar in normal women in the early follicular phase, women with premature ovarian failure, postmenopausal women not receiving estrogen, and women with gonadal dysgenesis.

    In plain wordsThe body's own thymosin beta‑4 in blood was similar in normal women, women with early ovarian failure, postmenopausal women and women with gonadal dysgenesis.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeBasal thymosin beta 4 across several groups of women
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Basal levels of thymosin beta 4 were similar in normal women during the early follicular phase, women with premature ovarian failure, postmenopausal women not receiving estrogen, and individuals with gonadal dysgenesis.
    1 context sentence
    Summary · context
    To determine whether steroid hormones modulate secretion of thymic peptides, basal concentrations of thymosins alpha 1 and beta 4 were determined by radioimmunoassay in morning blood samples from 87 women in various clinical states.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    Thymosin beta‑4 concentrations were reduced in castrated women not receiving estrogen.

    In plain wordsIn castrated women not on estrogen, the body's own thymosin beta‑4 in blood was lower.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta 4 in castrated women not receiving estrogen
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Thymosin beta 4 concentrations were reduced in castrated women not receiving estrogen
    1 context sentence
    Summary · context
    To determine whether steroid hormones modulate secretion of thymic peptides, basal concentrations of thymosins alpha 1 and beta 4 were determined by radioimmunoassay in morning blood samples from 87 women in various clinical states.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Thymosin beta‑4 concentrations were decreased more in postmenopausal women and in castrated women on chronic estrogen therapy.

    In plain wordsIn postmenopausal women and castrated women on long-term estrogen, the body's own thymosin beta‑4 in blood was lower still.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta 4 in postmenopausal and castrated women on chronic estrogen
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    were decreased more in both postmenopausal women and castrated women who were on chronic estrogen therapy.
    1 context sentence
    Summary · context
    To determine whether steroid hormones modulate secretion of thymic peptides, basal concentrations of thymosins alpha 1 and beta 4 were determined by radioimmunoassay in morning blood samples from 87 women in various clinical states.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    12 Oct 2026, 18:17 UTC

    Study data updated · source update from Europe PMC

  2. Version 3

    10 Oct 2026, 08:55 UTC

    Study results updated

  3. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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