The effects of experimental hyperinsulinemia on steroid secretion, ovarian [125I]insulin binding, and ovarian [125I]insulin-like growth-factor I binding in the rat.

Poretsky L, Glover B, Laumas V, Kalin M, Dunaif A

Endocrinology1 Feb 1988Cited by 48 (Europe PMC)

PMID2962853DOI10.1210/endo-122-2-581PepBankPUB-02962853

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Gonadorelin (GnRH, LHRH).

01AnimalNot a test of Gonadorelin (GnRH, LHRH) aloneAnimal study (in vivo)Other
In female rats, hyperinsulinemia did not significantly change serum LH after a GnRH injection compared with vehicle controls.
In plain wordsIn rats, high insulin did not significantly change the LH response to GnRH compared with controls.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changeGnRH-stimulated LH with hyperinsulinemia
Study
ratn = 32
Cycling female Sprague-Dawley rats with insulin-induced hyperinsulinemia
Comparator
Vehicle control
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
or in GnRH-stimulated serum levels of LH or FSH.
2 context sentences(design, population, supporting numbers)
Summary · context
We randomized 32 cycling female Sprague-Dawley rats (82 days old) into experimental and control groups (16 animals/group).
Summary · context
Fifteen minutes before death, each rat received a sc injection of 100 ng synthetic GnRH (Factrel, Ayerst Laboratories, New York, NY).
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0296285301
02AnimalNot a test of Gonadorelin (GnRH, LHRH) aloneAnimal study (in vivo)Other
In female rats, hyperinsulinemia did not significantly change serum FSH after a GnRH injection compared with vehicle controls.
In plain wordsIn rats, high insulin did not significantly change the FSH response to GnRH compared with controls.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changeGnRH-stimulated FSH with hyperinsulinemia
Study
ratn = 32
Cycling female Sprague-Dawley rats with insulin-induced hyperinsulinemia
Comparator
Vehicle control
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
or in GnRH-stimulated serum levels of LH or FSH.
2 context sentences(design, population, supporting numbers)
Summary · context
We randomized 32 cycling female Sprague-Dawley rats (82 days old) into experimental and control groups (16 animals/group).
Summary · context
Fifteen minutes before death, each rat received a sc injection of 100 ng synthetic GnRH (Factrel, Ayerst Laboratories, New York, NY).
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0296285302

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.