Gonadotropin and alpha-subunit secretion during long term pituitary suppression by D-Trp6-luteinizing hormone-releasing hormone microcapsules as treatment of precocious puberty.

Lahlou N, Roger M, Chaussain JL, Feinstein MC, Sultan C, Toublanc JE, Schally AV, Scholler R

The Journal of clinical endocrinology and metabolism1 Nov 1987Cited by 49 (Europe PMC)

PMID2959680DOI10.1210/jcem-65-5-946PepBankPUB-02959680

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

11 results from studies that gave the peptide. 11 results from people.

01HumanNon-randomized trialEfficacy outcome
In girls with precocious puberty, RIA LH remained significantly above pretreatment levels until day 21 after triptorelin injection.
In plain wordsIn girls with early puberty, LH measured by RIA increased after triptorelin and remained elevated until day 21.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseRIA LH after first injection
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
After the first injection of LHRH-A, RIA LH levels were significantly higher than pretreatment levels until day 21, while IRMA LH levels transiently increased, but returned to pretreatment levels by day 7 and became lower thereafter (P less than 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968001
02HumanNon-randomized trialEfficacy outcome
In girls receiving triptorelin, IRMA LH rose transiently, returned to pretreatment levels by day 7, and then fell below them.
In plain wordsIn girls with early puberty, LH measured by IRMA first rose after triptorelin, then fell below pretreatment levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
MixedIRMA LH after first injection
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
After the first injection of LHRH-A, RIA LH levels were significantly higher than pretreatment levels until day 21, while IRMA LH levels transiently increased, but returned to pretreatment levels by day 7 and became lower thereafter (P less than 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968002
03HumanNon-randomized trialEfficacy outcome
In girls receiving triptorelin, plasma IR-Gn alpha increased from days 3-21.
In plain wordsIn girls with early puberty, alpha-subunit levels increased during triptorelin treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseEarly IR-Gn alpha
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
Plasma IR-Gn alpha levels increased from days 3-21 (P less than 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968003
04HumanNon-randomized trialEfficacy outcome
In girls receiving triptorelin, basal RIA LH remained detectable and unchanged from pretreatment at 1.5 months.
In plain wordsIn girls with early puberty, basal LH measured by RIA did not change after 1.5 months of triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeBasal RIA LH at 1.5 months
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
After 1.5 months of treatment, basal RIA LH levels remained detectable and not different from pretreatment levels; IRMA LH levels were very low.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968004
05HumanNon-randomized trialActivity measurement
In girls receiving triptorelin, basal IRMA LH was very low after 1.5 months.
In plain wordsIn girls with early puberty, basal LH measured by IRMA was very low during triptorelin treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableBasal IRMA LH at 1.5 months
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
After 1.5 months of treatment, basal RIA LH levels remained detectable and not different from pretreatment levels; IRMA LH levels were very low.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968005
06HumanNon-randomized trialEfficacy outcome
In girls receiving triptorelin, mean LH responses measured by RIA and IRMA decreased at 1.5 and 12 months.
In plain wordsIn girls with early puberty, triptorelin reduced LH responses to LHRH in both tests.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLHRH-stimulated LH response
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
The mean RIA and IRMA LH responses to LHRH were decreased at 1.5 and 12 months (P less than 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968006
07HumanNon-randomized trialEfficacy outcome
In girls receiving triptorelin, basal FSH measured by RIA and IRMA decreased from pretreatment values, with similar values between assays.
In plain wordsIn girls with early puberty, basal FSH decreased during triptorelin treatment in both tests.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseBasal FSH
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
Basal plasma RIA and IRMA FSH levels were similar during treatment (P greater than 0.05) and significantly lower than pretreatment values (P less than 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968007
08HumanNon-randomized trialEfficacy outcome
In girls receiving triptorelin, mean FSH responses to LHRH decreased significantly in both assays at 1.5 months.
In plain wordsIn girls with early puberty, triptorelin reduced FSH responses to LHRH at 1.5 months.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFSH response at 1.5 months
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
The mean RIA and IRMA FSH responses to LHRH decreased significantly at 1.5 months (P less than 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968008
09HumanNon-randomized trialEfficacy outcome
In girls receiving triptorelin, FSH responses increased after 12 months, with lower IRMA than RIA values.
In plain wordsIn girls with early puberty, FSH responses increased after 12 months of triptorelin, with lower values in the IRMA test.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFSH response at 12 months
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
After 12 months, both RIA and IRMA FSH responses were increased, but IRMA values were significantly lower than RIA values.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968009
10HumanNon-randomized trialEfficacy outcome
In girls receiving triptorelin, basal Gn alpha showed a sustained increase.
In plain wordsIn girls with early puberty, basal alpha-subunit levels remained elevated during triptorelin treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseSustained basal Gn alpha
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
A sustained increase in basal Gn alpha values occurred, but there was a tendency for the peak levels after LHRH treatment to decrease, becoming significantly lower than pretreatment peak levels after 1 yr.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968010
11HumanNon-randomized trialEfficacy outcome
In girls receiving triptorelin, peak Gn alpha responses to LHRH became significantly lower than pretreatment after 1 year.
In plain wordsIn girls with early puberty, peak alpha-subunit responses decreased after 1 year of triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePeak Gn alpha response
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
60 micrograms/kg every 28 days · intramuscular · 1 yrAs given in this study (human).
Source sentences
Summary
A sustained increase in basal Gn alpha values occurred, but there was a tendency for the peak levels after LHRH treatment to decrease, becoming significantly lower than pretreatment peak levels after 1 yr.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
Report a problemFND-0295968011

Studies that did not test the peptide alone1

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

12LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneIn vitro (cell-free)Activity measurement
In plasma from triptorelin-treated children, IR-Gn alpha coeluted with labeled Gn alpha on chromatography.
In plain wordsIn lab tests of plasma from triptorelin-treated children, alpha-subunit material separated with the labeled alpha-subunit standard.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableIR-Gn alpha chromatographic identity
Study
humann = 3
Chromatography of pooled plasma from three treated children
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
The chromatographic analysis on Sephadex G-100 of a pool of plasma samples collected during a LHRH test in three children treated for 6 months indicated that IR-Gn alpha coeluted with [125I]Gn alpha.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we examined the effect of D-Trp6-LHRH (LHRH-A) in microcapsules (60 micrograms/kg, im, every 28 days for 1 yr) in 13 girls suffering from precocious puberty.
Summary · context
Plasma IR-Gn alpha was measured by RIA; plasma IR-LH and IR-FSH were measured by both polyclonal RIAs and monoclonal immunoradiometric assays (IRMA).
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0295968012

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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