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Study · In vitro (cells) · 1987

7 results

Immunoregulatory effects of fraction 5 thymus peptides. I. Thymosin alpha 1 enhances while thymosin beta 4 suppresses the human autologous and allogeneic mixed lymphocyte reaction.

Baxevanis CN, Reclos GJ, Perez S, Kokkinopoulos D, Papamichail M

Immunopharmacology1 Apr 1987Cited by 32 (Europe PMC)

PMID2954929 (opens in a new tab)DOI10.1016/0162-3109(87)90050-6 (opens in a new tab)PepBankPUB-02954929
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In the human allogeneic mixed lymphocyte reaction, thymosin alpha‑1 enhanced the proliferative response.

    In plain wordsIn cells, thymosin alpha‑1 increased the immune cell response in a test that mixes cells from two donors.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAllogeneic MLR proliferative response
    Study

    humann: not reported in source

    Human mixed lymphocyte reaction (MLR)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha 1 was found capable of enhancing both the allogeneic and autologous MLR.
    1 context sentence
    Summary · context
    Thymosin alpha 1 and thymosin beta 4, two peptides isolated from preparations of calf thymus fraction 5, were tested in the human mixed lymphocyte reaction (MLR).
  2. 02LabIn vitro (cells)Activity measurement

    In the human autologous mixed lymphocyte reaction, thymosin alpha‑1 enhanced the proliferative response.

    In plain wordsIn cells, thymosin alpha‑1 increased the immune cell response in a test with a person's own cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAutologous MLR proliferative response
    Study

    humann: not reported in source

    Human mixed lymphocyte reaction (MLR)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha 1 was found capable of enhancing both the allogeneic and autologous MLR.
    1 context sentence
    Summary · context
    Thymosin alpha 1 and thymosin beta 4, two peptides isolated from preparations of calf thymus fraction 5, were tested in the human mixed lymphocyte reaction (MLR).
  3. 03LabIn vitro (cells)Activity measurement

    With thymosin alpha‑1, T4+ (helper/inducer) cells were responsible for the enhanced proliferative response to allo- and autoantigens.

    In plain wordsIn cells, helper T cells drove the stronger immune response seen with thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseProliferative response of T4+ (helper/inducer) cells
    Study

    humann: not reported in source

    Human mixed lymphocyte reaction (MLR)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Study of the responses of the T cell subpopulations revealed that T4+ (helper/inducer) cells but not T8+ (suppressor/cytotoxic) are responsible for the enhanced, proliferative response to allo- and autoantigens in the presence of thymosin alpha 1.
    1 context sentence
    Summary · context
    Thymosin alpha 1 and thymosin beta 4, two peptides isolated from preparations of calf thymus fraction 5, were tested in the human mixed lymphocyte reaction (MLR).
  4. 04LabIn vitro (cells)Activity measurement

    With thymosin alpha‑1, T8+ (suppressor/cytotoxic) cells were not responsible for the enhanced proliferative response.

    In plain wordsIn cells, suppressor and cytotoxic T cells did not drive the stronger response seen with thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeProliferative response of T8+ (suppressor/cytotoxic) cells
    Study

    humann: not reported in source

    Human mixed lymphocyte reaction (MLR)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Study of the responses of the T cell subpopulations revealed that T4+ (helper/inducer) cells but not T8+ (suppressor/cytotoxic) are responsible for the enhanced, proliferative response to allo- and autoantigens in the presence of thymosin alpha 1.
    1 context sentence
    Summary · context
    Thymosin alpha 1 and thymosin beta 4, two peptides isolated from preparations of calf thymus fraction 5, were tested in the human mixed lymphocyte reaction (MLR).
  5. 05LabIn vitro (cells)Activity measurement

    Thymosin beta‑4 suppressed the proliferative responses of the human mixed lymphocyte reaction.

    In plain wordsIn cells, thymosin beta‑4 lowered the growth response of human mixed lymphocyte cultures.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMixed lymphocyte reaction proliferative responses
    Study

    humann: not reported in source

    Human mixed lymphocyte reaction
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the contrary, thymosin beta 4 suppressed MLR proliferative responses.
    1 context sentence
    Summary · context
    Thymosin alpha 1 and thymosin beta 4, two peptides isolated from preparations of calf thymus fraction 5, were tested in the human mixed lymphocyte reaction (MLR).
  6. 06LabIn vitro (cells)Activity measurement

    Thymosin beta‑4 did not influence the autologous or allogeneic proliferative responses of T4+ cells or T8+ cells cultured alone.

    In plain wordsIn cells, thymosin beta‑4 did not change the growth response of T4+ cells or T8+ cells grown alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeProliferative response of isolated T4+ or T8+ cells
    Study

    humann: not reported in source

    Human mixed lymphocyte reaction
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both the autologous and the allogeneic proliferative responses of either T4+ cells or T8+ cells were not influenced by the addition of thymosin beta 4 in the cultures.
    1 context sentence
    Summary · context
    Thymosin alpha 1 and thymosin beta 4, two peptides isolated from preparations of calf thymus fraction 5, were tested in the human mixed lymphocyte reaction (MLR).
  7. 07LabIn vitro (cells)Activity measurement

    In cocultures of T4+ and T8+ cells, thymosin beta‑4 activated T8+ cells to suppress the allogeneic and autologous proliferative response of T4+ cells.

    In plain wordsIn cells, thymosin beta‑4 made T8+ cells suppress the growth response of T4+ cells when both were grown together.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseSuppression of T4+ cell response in T4+/T8+ coculture
    Study

    humann: not reported in source

    Human mixed lymphocyte reaction
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, when T4+ and T8+ subsets were cocultured, thymosin beta 4 was capable of activating T8+ cells to suppress the allogeneic and the autologous proliferative response of T4+ cells.
    1 context sentence
    Summary · context
    Thymosin alpha 1 and thymosin beta 4, two peptides isolated from preparations of calf thymus fraction 5, were tested in the human mixed lymphocyte reaction (MLR).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    12 Oct 2026, 18:17 UTC

    Study data updated · source update from Europe PMC

  2. Version 3

    10 Oct 2026, 08:55 UTC

    Study results updated

  3. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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