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Study · Not a test of the peptide alone · 1989

2 results

Evidence for the monomeric nature of thymosins.

Haritos AA, Yialouris PP, Heimer EP, Felix AM, Hannappel E, Rosemeyer MA

FEBS letters1 Feb 1989Cited by 13 (Europe PMC)

PMID2920828 (opens in a new tab)DOI10.1016/0014-5793(89)80547-2 (opens in a new tab)PepBankPUB-02920828
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Other

    Sedimentation equilibrium ultracentrifugation gave thymosin beta‑4 a relative molecular mass of 4600, close to its sequence value, which shows a monomer in solution.

    In plain wordsIn lab tests, thymosin beta‑4 behaved as a single molecule in solution, not as a larger cluster.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableRelative molecular mass of thymosin beta 4 by sedimentation equilibrium
    Study

    n: not reported in source

    solution
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Measurements

    relative molecular mass
    4600 Mr
    thymosin beta 4, sedimentation equilibrium

    Source sentences

    Summary
    However, on analysis by sedimentation equilibrium ultracentrifugation, prothymosin alpha and thymosin beta 4 showed relative molecular masses of 12,800 and 4600, which are close to the values calculated from their amino acid sequences, confirming their existence in solution as discrete monomeric entities.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Other

    In gel-filtration experiments, alpha- and beta-thymosins as a group appeared as oligomers 4-5-fold larger than the polypeptides.

    In plain wordsIn lab tests, gel filtration made the thymosins look 4-5-fold larger than their single molecules.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableApparent size of alpha- and beta-thymosins by gel filtration
    Study

    n: not reported in source

    solution
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Source sentences

    Summary
    According to gel-filtration experiments, alpha- and beta-thymosins appear to form oligomers, which are 4-5-fold larger than the corresponding polypeptides.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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