Thymosins alpha 1 and beta 4 potentiate the antigen-presenting capacity of macrophages.

Tzehoval E, Sztein MB, Goldstein AL

Immunopharmacology1 Sept 1989Cited by 28 (Europe PMC)

PMID2807872DOI10.1016/0162-3109(89)90063-5PepBankPUB-02807872

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
Thymosin presence during macrophage pulsing with KLH significantly enhanced lymph node cell proliferation to KLH in mice.
In plain wordsIn mice, thymosins present during antigen pulsing raised lymph node cell growth in response to the antigen.
Peptide
Thymosin alpha-1
Outcome
IncreaseLymph node cell proliferation to KLH
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-8) to 10(-10) M · in vitroAs given in this study (mouse).
Source sentences
Summary
the presence of thymosins during the pulsing of macrophages with KLH led to significantly enhanced lymph node cell proliferation responses to KLH
2 context sentences(design, population, supporting numbers)
Summary · context
The concentrations of T alpha 1 and T beta 4 required for amplification were 10(-8) to 10(-10) M, well within the physiological range of activity of most peptide hormones.
Summary · context
Macrophage monolayers were pulsed with keyhole limpet hemocyanin (KLH) in the absence or presence of thymosins, washed and overlaid with spleen cells.
Report a problemFND-0280787202
02LabEx vivo tissueMechanism
Thymosin presence during macrophage pulsing with KLH was correlated with increased IL-2 production in lymph node cells.
In plain wordsIn mice, thymosins present during antigen pulsing went with higher IL-2 production.
Peptide
Thymosin alpha-1
Outcome
IncreaseIL-2 production
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-8) to 10(-10) M · in vitroAs given in this study (mouse).
Source sentences
Summary
the presence of thymosins during the pulsing of macrophages with KLH led to significantly enhanced lymph node cell proliferation responses to KLH was correlated to increased IL-2 production and IL-2R expression.
2 context sentences(design, population, supporting numbers)
Summary · context
The concentrations of T alpha 1 and T beta 4 required for amplification were 10(-8) to 10(-10) M, well within the physiological range of activity of most peptide hormones.
Summary · context
Macrophage monolayers were pulsed with keyhole limpet hemocyanin (KLH) in the absence or presence of thymosins, washed and overlaid with spleen cells.
Report a problemFND-0280787203
03LabEx vivo tissueMechanism
Thymosin presence during macrophage pulsing with KLH was correlated with increased IL-2 receptor expression on lymph node cells.
In plain wordsIn mice, thymosins present during antigen pulsing went with more IL-2 receptors on cells.
Peptide
Thymosin alpha-1
Outcome
IncreaseIL-2 receptor expression
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-8) to 10(-10) M · in vitroAs given in this study (mouse).
Source sentences
Summary
the presence of thymosins during the pulsing of macrophages with KLH led to significantly enhanced lymph node cell proliferation responses to KLH was correlated to increased IL-2 production and IL-2R expression.
2 context sentences(design, population, supporting numbers)
Summary · context
The concentrations of T alpha 1 and T beta 4 required for amplification were 10(-8) to 10(-10) M, well within the physiological range of activity of most peptide hormones.
Summary · context
Macrophage monolayers were pulsed with keyhole limpet hemocyanin (KLH) in the absence or presence of thymosins, washed and overlaid with spleen cells.
Report a problemFND-0280787204
04LabEx vivo tissueMechanism
The enhanced IL-2 secretion with thymosins was not accompanied by IL-4 production.
In plain wordsIn mice, the thymosins raised IL-2 but did not raise IL-4 production.
Peptide
Thymosin alpha-1
Outcome
No significant changeIL-4 production
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-8) to 10(-10) M · in vitroAs given in this study (mouse).
Source sentences
Summary
The observed enhancement of IL-2 secretion was not accompanied by interleukin 4 (IL-4) production.
1 context sentence(design, population, supporting numbers)
Summary · context
Macrophage monolayers were pulsed with keyhole limpet hemocyanin (KLH) in the absence or presence of thymosins, washed and overlaid with spleen cells.
Report a problemFND-0280787205
05LabEx vivo tissueActivity measurement
In an in vitro macrophage-dependent T-cell proliferation system, thymosin beta‑4 augmented the antigen-presenting capacity of macrophages.
In plain wordsIn lab tests with mouse cells, thymosin beta‑4 made macrophages better at presenting antigen to immune cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseAntigen-presenting capacity of macrophages
Study
mousen: not reported in source
KLH-pulsed macrophage-dependent T-cell proliferation system
Comparator
Macrophages pulsed without thymosins
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-8) to 10(-10) MAs given in this study (mouse).
Source sentences
Summary
Using an in vitro antigen (Ag)-specific macrophage-dependent T-cell proliferation system, we found that both thymosin alpha 1 (T alpha 1) and thymosin beta 4 (T beta 4) augment the Ag-presenting capacity of macrophages.
2 context sentences(design, population, supporting numbers)
Summary · context
Macrophage monolayers were pulsed with keyhole limpet hemocyanin (KLH) in the absence or presence of thymosins, washed and overlaid with spleen cells.
Summary · context
The concentrations of T alpha 1 and T beta 4 required for amplification were 10(-8) to 10(-10) M, well within the physiological range of activity of most peptide hormones.
Report a problemFND-0280787206
06LabEx vivo tissueActivity measurement
Macrophages pulsed with KLH in the presence of thymosin beta‑4 led to significantly enhanced lymph node cell proliferation to KLH.
In plain wordsIn lab tests with mouse cells, thymosin beta‑4 increased the growth of immune cells that respond to the antigen.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseLymph node cell proliferation to KLH
Study
mousen: not reported in source
KLH-pulsed macrophage-dependent T-cell proliferation system
Comparator
Macrophages pulsed without thymosins
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-8) to 10(-10) MAs given in this study (mouse).
Source sentences
Summary
We found that the presence of thymosins during the pulsing of macrophages with KLH led to significantly enhanced lymph node cell proliferation responses to KLH was correlated to increased IL-2 production and IL-2R expression.
3 context sentences(design, population, supporting numbers)
Summary · context
Using an in vitro antigen (Ag)-specific macrophage-dependent T-cell proliferation system, we found that both thymosin alpha 1 (T alpha 1) and thymosin beta 4 (T beta 4) augment the Ag-presenting capacity of macrophages.
Summary · context
Macrophage monolayers were pulsed with keyhole limpet hemocyanin (KLH) in the absence or presence of thymosins, washed and overlaid with spleen cells.
Summary · context
The concentrations of T alpha 1 and T beta 4 required for amplification were 10(-8) to 10(-10) M, well within the physiological range of activity of most peptide hormones.
Report a problemFND-0280787207
07LabEx vivo tissueActivity measurement
Macrophages pulsed with KLH in the presence of thymosin beta‑4 led to increased IL-2 production by lymph node cells.
In plain wordsIn lab tests with mouse cells, thymosin beta‑4 increased IL-2 production by immune cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseIL-2 production
Study
mousen: not reported in source
KLH-pulsed macrophage-dependent T-cell proliferation system
Comparator
Macrophages pulsed without thymosins
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-8) to 10(-10) MAs given in this study (mouse).
Source sentences
Summary
We found that the presence of thymosins during the pulsing of macrophages with KLH led to significantly enhanced lymph node cell proliferation responses to KLH was correlated to increased IL-2 production and IL-2R expression.
3 context sentences(design, population, supporting numbers)
Summary · context
Using an in vitro antigen (Ag)-specific macrophage-dependent T-cell proliferation system, we found that both thymosin alpha 1 (T alpha 1) and thymosin beta 4 (T beta 4) augment the Ag-presenting capacity of macrophages.
Summary · context
Macrophage monolayers were pulsed with keyhole limpet hemocyanin (KLH) in the absence or presence of thymosins, washed and overlaid with spleen cells.
Summary · context
The concentrations of T alpha 1 and T beta 4 required for amplification were 10(-8) to 10(-10) M, well within the physiological range of activity of most peptide hormones.
Report a problemFND-0280787208
08LabEx vivo tissueActivity measurement
Macrophages pulsed with KLH in the presence of thymosin beta‑4 led to increased IL-2 receptor expression on lymph node cells.
In plain wordsIn lab tests with mouse cells, thymosin beta‑4 increased IL-2 receptor levels on immune cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseIL-2 receptor expression
Study
mousen: not reported in source
KLH-pulsed macrophage-dependent T-cell proliferation system
Comparator
Macrophages pulsed without thymosins
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-8) to 10(-10) MAs given in this study (mouse).
Source sentences
Summary
We found that the presence of thymosins during the pulsing of macrophages with KLH led to significantly enhanced lymph node cell proliferation responses to KLH was correlated to increased IL-2 production and IL-2R expression.
3 context sentences(design, population, supporting numbers)
Summary · context
Using an in vitro antigen (Ag)-specific macrophage-dependent T-cell proliferation system, we found that both thymosin alpha 1 (T alpha 1) and thymosin beta 4 (T beta 4) augment the Ag-presenting capacity of macrophages.
Summary · context
Macrophage monolayers were pulsed with keyhole limpet hemocyanin (KLH) in the absence or presence of thymosins, washed and overlaid with spleen cells.
Summary · context
The concentrations of T alpha 1 and T beta 4 required for amplification were 10(-8) to 10(-10) M, well within the physiological range of activity of most peptide hormones.
Report a problemFND-0280787209
09LabEx vivo tissueActivity measurement
In the macrophage antigen-presentation system, the thymosin beta‑4-enhanced IL-2 secretion was not accompanied by IL-4 production.
In plain wordsIn lab tests with mouse cells, thymosin beta‑4 raised IL-2 but IL-4 was not produced.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeIL-4 production
Study
mousen: not reported in source
KLH-pulsed macrophage-dependent T-cell proliferation system
Comparator
Macrophages pulsed without thymosins
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-8) to 10(-10) MAs given in this study (mouse).
Source sentences
Summary
The observed enhancement of IL-2 secretion was not accompanied by interleukin 4 (IL-4) production.
3 context sentences(design, population, supporting numbers)
Summary · context
Using an in vitro antigen (Ag)-specific macrophage-dependent T-cell proliferation system, we found that both thymosin alpha 1 (T alpha 1) and thymosin beta 4 (T beta 4) augment the Ag-presenting capacity of macrophages.
Summary · context
Macrophage monolayers were pulsed with keyhole limpet hemocyanin (KLH) in the absence or presence of thymosins, washed and overlaid with spleen cells.
Summary · context
The concentrations of T alpha 1 and T beta 4 required for amplification were 10(-8) to 10(-10) M, well within the physiological range of activity of most peptide hormones.
Report a problemFND-0280787210
10LabIn vitro (cells)Mechanism
In an in vitro macrophage and T-cell system, thymosin alpha‑1 augmented the antigen-presenting capacity of macrophages.
In plain wordsIn lab tests with mouse cells, thymosin alpha‑1 made macrophages better at presenting antigen.
Peptide
Thymosin alpha-1
Outcome
IncreaseAntigen-presenting capacity of macrophages
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-8) to 10(-10) M · in vitroAs given in this study (mouse).
Source sentences
Summary
Using an in vitro antigen (Ag)-specific macrophage-dependent T-cell proliferation system, we found that both thymosin alpha 1 (T alpha 1) and thymosin beta 4 (T beta 4) augment the Ag-presenting capacity of macrophages.
2 context sentences(design, population, supporting numbers)
Summary · context
The concentrations of T alpha 1 and T beta 4 required for amplification were 10(-8) to 10(-10) M, well within the physiological range of activity of most peptide hormones.
Summary · context
Macrophage monolayers were pulsed with keyhole limpet hemocyanin (KLH) in the absence or presence of thymosins, washed and overlaid with spleen cells.
Report a problemFND-0280787201

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 4Current
12 Oct 2026, 18:17 UTC
Study data updated · source update from Europe PMC
Version 3
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Thymosins alpha 1 and beta 4 potentiate the antigen-presenting capacity of macrophages.

Summary

Results from this study10

Version history

Subjects

Publication types

MeSH terms