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Study · Animal study (in vivo) · rat · 1989

6 results

[Structural and cytochemical changes in cerebral cortical neurons of the offspring of neurosensitized female rats after prenatal administration of thymalin].

Kazakova PB, Konokotina GF

Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952)1 Jan 1989

PMID2800803 (opens in a new tab)PepBankPUB-02800803
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In offspring of neurosensitized rats, maternal timalin treatment prevented dystrophic changes in cortical neurons.

    In plain wordsIn rats born to neurosensitized mothers, maternal timalin treatment prevented cortical neuron damage.

    Peptide
    Thymalin
    Outcome
    DecreaseCortical neuron dystrophy
    Study

    ratn: not reported in source

    Offspring of neurosensitized mothers treated during gestation
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Course treatment with the drug prevented the development of dystrophic changes in cortical neurons, their death and decrease in cell density within the cortical layers.
    1 context sentence
    Summary · context
    Age-related features of structural and cytochemical changes in the brain cortical neurons were investigated in offspring of rats which were neurosensitized and received a course of timalin treatment during gestation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In offspring of neurosensitized rats, maternal timalin treatment prevented cortical neuron death.

    In plain wordsIn rats born to neurosensitized mothers, maternal timalin treatment prevented cortical neuron death.

    Peptide
    Thymalin
    Outcome
    DecreaseCortical neuron death
    Study

    ratn: not reported in source

    Offspring of neurosensitized mothers treated during gestation
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Course treatment with the drug prevented the development of dystrophic changes in cortical neurons, their death and decrease in cell density within the cortical layers.
    1 context sentence
    Summary · context
    Age-related features of structural and cytochemical changes in the brain cortical neurons were investigated in offspring of rats which were neurosensitized and received a course of timalin treatment during gestation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In offspring of neurosensitized rats, maternal timalin treatment prevented decreases in cortical cell density.

    In plain wordsIn rats born to neurosensitized mothers, maternal timalin treatment prevented decreases in cortical cell density.

    Peptide
    Thymalin
    Outcome
    DecreaseCortical cell density loss
    Study

    ratn: not reported in source

    Offspring of neurosensitized mothers treated during gestation
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Course treatment with the drug prevented the development of dystrophic changes in cortical neurons, their death and decrease in cell density within the cortical layers.
    1 context sentence
    Summary · context
    Age-related features of structural and cytochemical changes in the brain cortical neurons were investigated in offspring of rats which were neurosensitized and received a course of timalin treatment during gestation.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In offspring of neurosensitized rats, maternal timalin treatment increased neuronal nuclear protein content.

    In plain wordsIn rats born to neurosensitized mothers, maternal timalin treatment increased protein in neuron nuclei.

    Peptide
    Thymalin
    Outcome
    IncreaseNuclear protein content
    Study

    ratn: not reported in source

    Offspring of neurosensitized mothers treated during gestation
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Timalin acted positive in terms of increase in protein content of the cellular nucleus and especially in the cytoplasm.
    1 context sentence
    Summary · context
    Age-related features of structural and cytochemical changes in the brain cortical neurons were investigated in offspring of rats which were neurosensitized and received a course of timalin treatment during gestation.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In offspring of neurosensitized rats, maternal timalin treatment increased protein content particularly in neuronal cytoplasm.

    In plain wordsIn rats born to neurosensitized mothers, maternal timalin treatment increased protein particularly in neuron cytoplasm.

    Peptide
    Thymalin
    Outcome
    IncreaseCytoplasmic protein content
    Study

    ratn: not reported in source

    Offspring of neurosensitized mothers treated during gestation
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Timalin acted positive in terms of increase in protein content of the cellular nucleus and especially in the cytoplasm.
    1 context sentence
    Summary · context
    Age-related features of structural and cytochemical changes in the brain cortical neurons were investigated in offspring of rats which were neurosensitized and received a course of timalin treatment during gestation.
  6. 06AnimalAnimal study (in vivo)Other

    In offspring of neurosensitized rats, timalin-associated neuronal effects were more pronounced in aged animals.

    In plain wordsIn rats born to neurosensitized mothers, timalin-associated neuron effects were stronger in aged animals than in younger animals.

    Peptide
    Thymalin
    Outcome
    IncreaseAge dependence of neuronal effects
    Study

    ratn: not reported in source

    Offspring of neurosensitized mothers treated during gestation
    Comparator
    Younger animals
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These effects were more pronounced in aged animals.
    2 context sentences
    Summary · context
    Course treatment with the drug prevented the development of dystrophic changes in cortical neurons, their death and decrease in cell density within the cortical layers. Timalin acted positive in terms of increase in protein content of the cellular nucleus and especially in the cytoplasm.
    Summary · context
    Age-related features of structural and cytochemical changes in the brain cortical neurons were investigated in offspring of rats which were neurosensitized and received a course of timalin treatment during gestation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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