In male rats exposed to NSEE, thymogen decreased esophageal and forestomach tumor incidence by 12%.
In plain wordsIn rats exposed to NSEE, thymogen decreased esophageal and forestomach tumor incidence by 12%.
- Peptide
- Thymogen (oglufanide)
- Outcome
- DecreaseEsophageal and forestomach tumor incidence
- Study
ratn: not reported in source
Male rats with NSEE-induced esophageal and forestomach carcinogenesis- Outcome group
- Tumor growth · Cancer
- Studied dose
- 10 micrograms per rat daily · 32 weeksAs given in this study (rat).
Measurements
- Tumour incidence reduction
- 12%
- thymogen-treated rats
Source sentences
Thymogen decreased the tumour incidence by 12% and made tumour multiplicity 1.7 times as low.
2 context sentences(design, population, supporting numbers)
Immunostimulating synthetic peptide thymogen being an analog of the thymus polypeptide drug thymalin was studied for its effect on carcinogenesis of the esophagus and forestomach in male rats.
After cessation of the carcinogen administration rats were treated with thymogen (the daily dose of 10 micrograms per rat) or immune-inactive polypeptide drug pulmolin from the alveolar tissue of lung (the daily dose of 0.5 mg per rat) during the following 32 weeks.