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Study · Non-randomized trial · n = 35 · 1989

8 results

[Effect of thymalin on immunologic reactivity of patients with non-specific lung diseases].

Dovnar TE, Mikhaĭlova NA, Khavinson VKh

Terapevticheskii arkhiv1 Jan 1989

PMID2741122 (opens in a new tab)PepBankPUB-02741122
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with non-specific pulmonary diseases, thymalin favored lymphocyte count normalization compared with standard treatment alone.

    In plain wordsIn pulmonary disease patients, thymalin favored normal lymphocyte counts compared with standard treatment alone.

    Peptide
    Thymalin
    Outcome
    Not applicableLymphocyte count
    Study

    n = 35

    Comparator
    Standard treatment control group
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5 ml, 4-6 injections per treatment courseAs given in this study (human).

    Source sentences

    Summary
    Immunologic studies made it possible to establish that administration of thymalin in relatively small doses (5 ml, 4-6 injections per treatment course) is an effective means of correcting the decreased characteristics of cellular immunity, favouring the normalization of the lymphocyte count and of t…
    3 context sentences
    Summary · context
    A total of 35 patients with non-specific pulmonary diseases were examined.
    Summary · context
    Twenty-one patients were administered thymalin in addition to standard treatment.
    Summary · context
    Fourteen subjects made up a control group.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with non-specific pulmonary diseases, thymalin favored normalization of the OKT-4+ subpopulation proportion compared with standard treatment alone.

    In plain wordsIn pulmonary disease patients, thymalin favored normal OKT-4+ immune cell proportions compared with standard treatment alone.

    Peptide
    Thymalin
    Outcome
    Not applicableOKT-4+ subpopulation proportion
    Study

    n = 35

    Comparator
    Standard treatment control group
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5 ml, 4-6 injections per treatment courseAs given in this study (human).

    Source sentences

    Summary
    Immunologic studies made it possible to establish that administration of thymalin in relatively small doses (5 ml, 4-6 injections per treatment course) is an effective means of correcting the decreased characteristics of cellular immunity, favouring the normalization of the lymphocyte count and of t…
    3 context sentences
    Summary · context
    A total of 35 patients with non-specific pulmonary diseases were examined.
    Summary · context
    Twenty-one patients were administered thymalin in addition to standard treatment.
    Summary · context
    Fourteen subjects made up a control group.
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients with non-specific pulmonary diseases, thymalin favored normalization of the OKT-8+ subpopulation proportion compared with standard treatment alone.

    In plain wordsIn pulmonary disease patients, thymalin favored normal OKT-8+ immune cell proportions compared with standard treatment alone.

    Peptide
    Thymalin
    Outcome
    Not applicableOKT-8+ subpopulation proportion
    Study

    n = 35

    Comparator
    Standard treatment control group
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5 ml, 4-6 injections per treatment courseAs given in this study (human).

    Source sentences

    Summary
    Immunologic studies made it possible to establish that administration of thymalin in relatively small doses (5 ml, 4-6 injections per treatment course) is an effective means of correcting the decreased characteristics of cellular immunity, favouring the normalization of the lymphocyte count and of t…
    3 context sentences
    Summary · context
    A total of 35 patients with non-specific pulmonary diseases were examined.
    Summary · context
    Twenty-one patients were administered thymalin in addition to standard treatment.
    Summary · context
    Fourteen subjects made up a control group.
  4. 04HumanNon-randomized trialEfficacy outcome

    In patients with non-specific pulmonary diseases, thymalin exerted no substantial effect on leukocyte chemotaxis compared with standard treatment alone.

    In plain wordsIn pulmonary disease patients, thymalin did not substantially change leukocyte movement compared with standard treatment alone.

    Peptide
    Thymalin
    Outcome
    No significant changeLeukocyte chemotaxis
    Study

    n = 35

    Comparator
    Standard treatment control group
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5 ml, 4-6 injections per treatment courseAs given in this study (human).

    Source sentences

    Summary
    The drug was found to exert no substantial effect on the other characteristics of immunity, namely on chemotaxis and phagocytosis of leukocytes, the content of immunoglobulins and on circulating immune complexes.
    3 context sentences
    Summary · context
    A total of 35 patients with non-specific pulmonary diseases were examined.
    Summary · context
    Twenty-one patients were administered thymalin in addition to standard treatment.
    Summary · context
    Fourteen subjects made up a control group.
  5. 05HumanNon-randomized trialEfficacy outcome

    In patients with non-specific pulmonary diseases, thymalin exerted no substantial effect on leukocyte phagocytosis compared with standard treatment alone.

    In plain wordsIn pulmonary disease patients, thymalin did not substantially change leukocyte phagocytosis compared with standard treatment alone.

    Peptide
    Thymalin
    Outcome
    No significant changeLeukocyte phagocytosis
    Study

    n = 35

    Comparator
    Standard treatment control group
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5 ml, 4-6 injections per treatment courseAs given in this study (human).

    Source sentences

    Summary
    The drug was found to exert no substantial effect on the other characteristics of immunity, namely on chemotaxis and phagocytosis of leukocytes, the content of immunoglobulins and on circulating immune complexes.
    3 context sentences
    Summary · context
    A total of 35 patients with non-specific pulmonary diseases were examined.
    Summary · context
    Twenty-one patients were administered thymalin in addition to standard treatment.
    Summary · context
    Fourteen subjects made up a control group.
  6. 06HumanNon-randomized trialEfficacy outcome

    In patients with non-specific pulmonary diseases, thymalin exerted no substantial effect on immunoglobulin content compared with standard treatment alone.

    In plain wordsIn pulmonary disease patients, thymalin did not substantially change antibody content compared with standard treatment alone.

    Peptide
    Thymalin
    Outcome
    No significant changeImmunoglobulin content
    Study

    n = 35

    Comparator
    Standard treatment control group
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5 ml, 4-6 injections per treatment courseAs given in this study (human).

    Source sentences

    Summary
    The drug was found to exert no substantial effect on the other characteristics of immunity, namely on chemotaxis and phagocytosis of leukocytes, the content of immunoglobulins and on circulating immune complexes.
    3 context sentences
    Summary · context
    A total of 35 patients with non-specific pulmonary diseases were examined.
    Summary · context
    Twenty-one patients were administered thymalin in addition to standard treatment.
    Summary · context
    Fourteen subjects made up a control group.
  7. 07HumanNon-randomized trialEfficacy outcome

    In patients with non-specific pulmonary diseases, thymalin exerted no substantial effect on circulating immune complexes compared with standard treatment alone.

    In plain wordsIn pulmonary disease patients, thymalin did not substantially change circulating immune complexes compared with standard treatment alone.

    Peptide
    Thymalin
    Outcome
    No significant changeCirculating immune complexes
    Study

    n = 35

    Comparator
    Standard treatment control group
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5 ml, 4-6 injections per treatment courseAs given in this study (human).

    Source sentences

    Summary
    The drug was found to exert no substantial effect on the other characteristics of immunity, namely on chemotaxis and phagocytosis of leukocytes, the content of immunoglobulins and on circulating immune complexes.
    3 context sentences
    Summary · context
    A total of 35 patients with non-specific pulmonary diseases were examined.
    Summary · context
    Twenty-one patients were administered thymalin in addition to standard treatment.
    Summary · context
    Fourteen subjects made up a control group.
  8. 08HumanNon-randomized trialEfficacy outcome

    In pulmonary disease patients with preserved phagocytic function, thymalin benefited the disease course compared with control treatment.

    In plain wordsIn pulmonary disease patients with preserved phagocytic function, thymalin improved the disease course compared with control treatment.

    Peptide
    Thymalin
    Outcome
    IncreaseDisease course with preserved phagocytic function
    Study

    n: not reported in source

    Comparator
    Standard treatment control group
    Outcome group
    Immune response · Respiratory
    Studied dose
    5 ml, 4-6 injections per treatment courseAs given in this study (human).

    Source sentences

    Summary
    Thymalin produced an appreciably beneficial action on the disease course in patients with preserved function of the phagocytic component.
    3 context sentences
    Summary · context
    A total of 35 patients with non-specific pulmonary diseases were examined.
    Summary · context
    Twenty-one patients were administered thymalin in addition to standard treatment.
    Summary · context
    Fourteen subjects made up a control group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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