In children with primary nocturnal enuresis, desmopressin plus alarm produced 5.1 +/- 0.4 dry nights weekly versus 4.1 +/- 0.4 with placebo plus alarm.
In plain wordsIn children with nocturnal enuresis, desmopressin plus alarm increased dry nights compared with placebo plus alarm.
- Peptide
- Desmopressin
- Outcome
- IncreaseDry nights per week
- Study
n = 28
- Comparator
- Alarm and placebo
- Outcome group
- Urinary continence and bladder function · Kidney and urinary
- Studied dose
- 20 micrograms · intranasal · 2 weeksAs given in this study (human).
Measurements
- Dry nights per week
- 5.1 nights/week
- desmopressin plus alarm, +/- 0.4 SEM
- Dry nights per week
- 4.1 nights/week
- placebo plus alarm, +/- 0.4 SEM
- p
- < 0.05
- desmopressin plus alarm versus placebo plus alarm
Source sentences
The combined treatment of desmopressin and alarm showed 5.1 +/- 0.4 (mean +/- SEM) dry nights per week and resulted in significantly more dry nights per week during the 2 weeks of observation than placebo and alarm (4.1 +/- 0.4, P less than 0.05).
2 context sentences(design, population, supporting numbers)
Twenty-eight children with primary nocturnal enuresis were blindly allocated at random to a combination of enuresis alarm and 20 micrograms intranasal desmopressin or alarm and placebo for 2 weeks.
Patients received the other therapy after a 2-week treatment-free period.