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Study · Measured the body's own peptide · 1989

5 results

Modulation of thymosin alpha 1 and thymosin beta 4 levels and peripheral blood mononuclear cell subsets during experimental rhinovirus colds.

Hsia J, Sztein MB, Naylor PH, Simon GL, Goldstein AL, Hayden FG

Lymphokine research1 Jan 1989Cited by 13 (Europe PMC)

PMID2572736 (opens in a new tab)PepBankPUB-02572736
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialOther

    In a second group of 20 healthy volunteers, serum thymosin alpha‑1 rose significantly on day 5 after rhinovirus inoculation (p less than .001).

    In plain wordsIn a second group of volunteers infected with a cold virus, the body's own thymosin alpha‑1 levels again rose clearly on day 5.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSerum thymosin alpha 1 on day 5 after rhinovirus challenge (second group)
    Study

    n = 20

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    there was a slight increase in thymosin alpha 1 levels on day 3 and a significant rise on day 5 (p less than .001)
    1 context sentence
    Summary · context
    Cellular immune response to localized upper respiratory viral infection was studied in two groups of healthy volunteers infected with an unnumbered rhinovirus serotype (Hanks).

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialOther

    In the second group of 20 volunteers, serum thymosin alpha‑1 showed a slight increase on day 3 after rhinovirus inoculation; significance is not stated.

    In plain wordsIn volunteers infected with a cold virus, the body's own thymosin alpha‑1 rose slightly on day 3.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSerum thymosin alpha 1 on day 3 after rhinovirus challenge (second group)
    Study

    n = 20

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    there was a slight increase in thymosin alpha 1 levels on day 3
    1 context sentence
    Summary · context
    Cellular immune response to localized upper respiratory viral infection was studied in two groups of healthy volunteers infected with an unnumbered rhinovirus serotype (Hanks).

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelNon-randomized trialOther

    In 18 healthy volunteers, serum levels of the body's own thymosin alpha‑1 rose on day 5 after rhinovirus challenge.

    In plain wordsIn healthy volunteers infected with a cold virus, the body's own thymosin alpha‑1 levels rose on day 5.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSerum thymosin alpha 1 on day 5 after rhinovirus challenge (first group)
    Study

    n = 18

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    In the first group of 18 volunteers, serum levels of thymosin alpha 1 rose on day 5 following rhinovirus challenge.
    1 context sentence
    Summary · context
    Cellular immune response to localized upper respiratory viral infection was studied in two groups of healthy volunteers infected with an unnumbered rhinovirus serotype (Hanks).

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelNon-randomized trialOther

    After rhinovirus inoculation, individual changes in serum cortisol were not directly related to changes in thymosin alpha‑1 levels.

    In plain wordsIn volunteers with a cold virus, changes in the body's own thymosin alpha‑1 were not directly linked to changes in cortisol.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeRelationship between changes in cortisol and thymosin alpha 1
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Serum cortisol rose in parallel with thymosin alpha 1 on day 5 after rhinovirus inoculation, but there was no direct relationship between individual changes in cortisol and thymosin alpha 1 levels.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelOther designMechanism

    In healthy volunteers infected with rhinovirus, the body's own serum thymosin beta‑4 level rose significantly on day 5.

    In plain wordsIn healthy volunteers with a rhinovirus cold, natural thymosin beta‑4 levels rose on day 5.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSerum thymosin beta 4 on day 5 after rhinovirus challenge
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    There was also a significant rise in serum thymosin beta 4 levels on day 5 (p less than .001).
    1 context sentence
    Summary · context
    Cellular immune response to localized upper respiratory viral infection was studied in two groups of healthy volunteers infected with an unnumbered rhinovirus serotype (Hanks).

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    12 Oct 2026, 18:17 UTC

    Study data updated · source update from Europe PMC

  2. Version 3

    10 Oct 2026, 08:55 UTC

    Study results updated

  3. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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