Alcohol effects on luteinizing hormone releasing hormone-stimulated anterior pituitary and gonadal hormones in women.

Mendelson JH, Mello NK, Teoh SK, Ellingboe J

The Journal of pharmacology and experimental therapeutics1 Sept 1989Cited by 20 (Europe PMC)

PMID2506337DOI10.1016/s0022-3565(25)22833-6PepBankPUB-02506337

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. 4 results from people.

01HumanNon-randomized trialActivity measurement
In 24 adult women, intravenous LHRH 100 micrograms significantly increased plasma LH after both alcohol and placebo, with an equivalent rise in the follicular and luteal phases.
In plain wordsIn 24 women, LHRH raised LH levels compared with before the dose, whether they had alcohol or placebo.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
IncreaseLH response to LHRH
Study
n = 24
Comparator
Before LHRH administration
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 micrograms · intravenousAs given in this study (human).
Source sentences
Summary
LHRH stimulated a significant increase in LH after both alcohol (P less than .0001) and placebo (P less than .0001) administration, and this LH increase was equivalent during the follicular and the luteal phases of the menstrual cycle.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol (E2) and progesterone were measured in 24 normal, adult women before and after i.v. administration of 100 micrograms luteinizing hormone releasing hormone (LHRH; Factrel) and p.o. ingestion of an alcohol (0.694…
Report a problemFND-0250633701
02HumanNon-randomized trialActivity measurement
In 24 adult women, LHRH significantly increased FSH after both alcohol and placebo in the follicular and luteal phases.
In plain wordsIn 24 women, LHRH raised FSH levels compared with before the dose, whether they had alcohol or placebo.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
IncreaseFSH response to LHRH
Study
n = 24
Comparator
Before LHRH administration
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 micrograms · intravenousAs given in this study (human).
Source sentences
Summary
LHRH also stimulated a significant increase in FSH levels after both alcohol and placebo intake during the follicular and luteal phases of the menstrual cycle (P less than .0001).
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol (E2) and progesterone were measured in 24 normal, adult women before and after i.v. administration of 100 micrograms luteinizing hormone releasing hormone (LHRH; Factrel) and p.o. ingestion of an alcohol (0.694…
Report a problemFND-0250633702
03HumanNon-randomized trialActivity measurement
In 24 adult women, plasma prolactin increased significantly after LHRH administration in the follicular and luteal phases.
In plain wordsIn 24 women, LHRH raised prolactin levels compared with before the dose.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
IncreaseProlactin response to LHRH
Study
n = 24
Comparator
Before LHRH administration
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 micrograms · intravenousAs given in this study (human).
Source sentences
Summary
Plasma prolactin levels also increased significantly after LHRH administration during the follicular and luteal phases of the menstrual cycle (P less than .0001).
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol (E2) and progesterone were measured in 24 normal, adult women before and after i.v. administration of 100 micrograms luteinizing hormone releasing hormone (LHRH; Factrel) and p.o. ingestion of an alcohol (0.694…
Report a problemFND-0250633703
04HumanNon-randomized trialActivity measurement
In women in the early follicular phase who received placebo alcohol, plasma estradiol did not increase significantly after LHRH administration.
In plain wordsIn women in the early follicular phase given placebo alcohol, LHRH did not significantly raise estradiol levels.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changeEstradiol response to LHRH, follicular phase, placebo alcohol
Study
n = 6
Comparator
Before LHRH administration
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 micrograms · intravenousAs given in this study (human).
Source sentences
Summary
Plasma E2 levels did not increase significantly after LHRH administration and placebo alcohol during the follicular phase of the menstrual cycle.(ABSTRACT TRUNCATED AT 250 WORDS)
1 context sentence(design, population, supporting numbers)
Summary · context
Twelve subjects were studied during the early follicular phase of the menstrual cycle and 12 subjects were studied during the midluteal phase of the menstrual cycle. During each menstrual cycle phase, six subjects received placebo solution and six subjects received alcohol solution administered unde…
Report a problemFND-0250633704

Studies that did not test the peptide alone2

In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Gonadorelin (GnRH, LHRH).

05HumanNot a test of Gonadorelin (GnRH, LHRH) aloneNon-randomized trialActivity measurement
In 24 adult women given LHRH, alcohol did not significantly change the LHRH-stimulated FSH response compared with placebo.
In plain wordsIn 24 women given LHRH, alcohol did not significantly change the FSH response compared with placebo.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changeAlcohol effect on LHRH-stimulated FSH
Study
n = 24
Comparator
Placebo solution
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
There were no significant differences in LHRH-stimulated FSH between the alcohol and placebo conditions.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol (E2) and progesterone were measured in 24 normal, adult women before and after i.v. administration of 100 micrograms luteinizing hormone releasing hormone (LHRH; Factrel) and p.o. ingestion of an alcohol (0.694…
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0250633705
06HumanNot a test of Gonadorelin (GnRH, LHRH) aloneNon-randomized trialActivity measurement
In 24 adult women given LHRH, alcohol did not significantly change the prolactin response to LHRH compared with placebo.
In plain wordsIn 24 women given LHRH, alcohol did not significantly change the prolactin response compared with placebo.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changeAlcohol effect on LHRH-stimulated prolactin
Study
n = 24
Comparator
Placebo solution
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
There were no significant differences in prolactin response to LHRH administration between the alcohol or placebo conditions during the follicular and luteal phases of the menstrual cycle.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol (E2) and progesterone were measured in 24 normal, adult women before and after i.v. administration of 100 micrograms luteinizing hormone releasing hormone (LHRH; Factrel) and p.o. ingestion of an alcohol (0.694…
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0250633706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.