Effect of glucagon on gastric emptying and on postprandial gastrin and insulin release in man.

Jonderko G, Jonderko K, Gołab T

Materia medica Polona. Polish journal of medicine and pharmacy1 Apr 1989Cited by 12 (Europe PMC)

PMID2488472PepBankPUB-02488472

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanNon-randomized trialEfficacy outcome
In normal males, glucagon reduced the gastric emptying index versus placebo: 0.358 +/- 0.090 versus 2.065 +/- 0.211 min-1.
In plain wordsIn normal males, glucagon slowed gastric emptying compared with placebo.
Peptide
Glucagon
Outcome
DecreaseGastric emptying index
Study
n = 9
Comparator
Placebo
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
0.5 mg bolus followed by 1.5 mg infusion · intravenous · 90 minutesAs given in this study (human).
Measurements
Emptying index
0.358 min-1
glucagon
Emptying index
2.065 min-1
placebo
Source sentences
Summary
Glucagon evoked a marked delay in gastric emptying in all patients studied--the emptying index, Ix: 2.065 +/- 0.211 min-1 after placebo vs 0.358 +/- 0.090 min-1 after glucagon, p less than 0.01.
2 context sentences(design, population, supporting numbers)
Summary · context
In a double-blind placebo-controlled study the effect of glucagon on gastric emptying, as well as on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after ingestion of a mixed solid-liquid meal was examined in nine normal males.
Summary · context
An i.v. bolus of 0.5 mg of crystalline glucagon was followed by 1.5 mg infused at a constant rate over 90 minutes.
Report a problemFND-0248847201
02HumanNon-randomized trialEfficacy outcome
In normal males, glucagon suppressed postprandial gastrin release during the first 60 minutes versus placebo.
In plain wordsIn normal males, glucagon suppressed early gastrin release after a meal compared with placebo.
Peptide
Glucagon
Outcome
DecreaseEarly postprandial gastrin release
Study
n = 9
Comparator
Placebo
Outcome group
Endogenous peptide levels · Gastrointestinal
Studied dose
0.5 mg bolus followed by 1.5 mg infusion · intravenous · 90 minutesAs given in this study (human).
Source sentences
Summary
The postprandial gastrin release was suppressed during the first 60 minutes of glucagon infusion and occurrence of the postprandial increment in the serum gastrin concentration was delayed.
2 context sentences(design, population, supporting numbers)
Summary · context
In a double-blind placebo-controlled study the effect of glucagon on gastric emptying, as well as on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after ingestion of a mixed solid-liquid meal was examined in nine normal males.
Summary · context
An i.v. bolus of 0.5 mg of crystalline glucagon was followed by 1.5 mg infused at a constant rate over 90 minutes.
Report a problemFND-0248847202
03HumanNon-randomized trialEfficacy outcome
In normal males, glucagon delayed the postprandial rise in serum gastrin versus placebo.
In plain wordsIn normal males, glucagon delayed the rise in gastrin after a meal compared with placebo.
Peptide
Glucagon
Outcome
IncreaseTiming of postprandial gastrin increment
Study
n = 9
Comparator
Placebo
Outcome group
Endogenous peptide levels · Gastrointestinal
Studied dose
0.5 mg bolus followed by 1.5 mg infusion · intravenous · 90 minutesAs given in this study (human).
Source sentences
Summary
The postprandial gastrin release was suppressed during the first 60 minutes of glucagon infusion and occurrence of the postprandial increment in the serum gastrin concentration was delayed.
2 context sentences(design, population, supporting numbers)
Summary · context
In a double-blind placebo-controlled study the effect of glucagon on gastric emptying, as well as on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after ingestion of a mixed solid-liquid meal was examined in nine normal males.
Summary · context
An i.v. bolus of 0.5 mg of crystalline glucagon was followed by 1.5 mg infused at a constant rate over 90 minutes.
Report a problemFND-0248847203
04HumanNon-randomized trialEfficacy outcome
In normal males, glucagon did not significantly change gastrin AUC versus placebo: 7434 +/- 1372 versus 8733 +/- 1502 min.ng.l-1.
In plain wordsIn normal males, glucagon did not significantly change the total gastrin response compared with placebo.
Peptide
Glucagon
Outcome
No significant changeIntegrated gastrin response
Study
n = 9
Comparator
Placebo
Outcome group
Endogenous peptide levels · Gastrointestinal
Studied dose
0.5 mg bolus followed by 1.5 mg infusion · intravenous · 90 minutesAs given in this study (human).
Measurements
Gastrin AUC
7434 min.ng.l-1
glucagon
Gastrin AUC
8733 min.ng.l-1
placebo
Source sentences
Summary
The integrated gastrin response did not, however, significantly change: the area under the gastrin curve, AUC0-90, 8733 +/- 1502 min.ng.l-1 after placebo vs 7434 +/- 1372 min.ng.l-1 after glucagon.
2 context sentences(design, population, supporting numbers)
Summary · context
In a double-blind placebo-controlled study the effect of glucagon on gastric emptying, as well as on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after ingestion of a mixed solid-liquid meal was examined in nine normal males.
Summary · context
An i.v. bolus of 0.5 mg of crystalline glucagon was followed by 1.5 mg infused at a constant rate over 90 minutes.
Report a problemFND-0248847204
05HumanNon-randomized trialEfficacy outcome
In normal males, glucagon significantly increased insulin AUC versus placebo: 3388 +/- 567 versus 1842 +/- 153 min.mU.l-1.
In plain wordsIn normal males, glucagon increased insulin release compared with placebo.
Peptide
Glucagon
Outcome
IncreaseInsulin AUC
Study
n = 9
Comparator
Placebo
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
0.5 mg bolus followed by 1.5 mg infusion · intravenous · 90 minutesAs given in this study (human).
Measurements
Insulin AUC
3388 min.mU.l-1
glucagon
Insulin AUC
1842 min.mU.l-1
placebo
Source sentences
Summary
A promotion of insulin release by glucagon was reflected by a significant increase in the area under the insulin curve, AUC0-90: 1842 +/- 153 min.mU.l-1 after placebo vs 3388 +/- 567 min.mU.l-1 after glucagon, p less than 0.02.
2 context sentences(design, population, supporting numbers)
Summary · context
In a double-blind placebo-controlled study the effect of glucagon on gastric emptying, as well as on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after ingestion of a mixed solid-liquid meal was examined in nine normal males.
Summary · context
An i.v. bolus of 0.5 mg of crystalline glucagon was followed by 1.5 mg infused at a constant rate over 90 minutes.
Report a problemFND-0248847205
06HumanNon-randomized trialEfficacy outcome
In normal males, glucagon produced an earlier and significantly higher serum glucose rise than placebo.
In plain wordsIn normal males, glucagon raised blood glucose earlier and higher than placebo.
Peptide
Glucagon
Outcome
IncreaseSerum glucose rise
Study
n = 9
Comparator
Placebo
Outcome group
Glycemic control · Metabolic and weight
Studied dose
0.5 mg bolus followed by 1.5 mg infusion · intravenous · 90 minutesAs given in this study (human).
Source sentences
Summary
Moreover, a sooner and significantly higher increase of the serum glucose level was observed during glucagon infusion when compared to the placebo situation.
2 context sentences(design, population, supporting numbers)
Summary · context
In a double-blind placebo-controlled study the effect of glucagon on gastric emptying, as well as on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after ingestion of a mixed solid-liquid meal was examined in nine normal males.
Summary · context
An i.v. bolus of 0.5 mg of crystalline glucagon was followed by 1.5 mg infused at a constant rate over 90 minutes.
Report a problemFND-0248847206
07HumanNon-randomized trialEfficacy outcome
In normal males, glucagon did not significantly change serum calcium versus placebo.
In plain wordsIn normal males, glucagon did not significantly change blood calcium compared with placebo.
Peptide
Glucagon
Outcome
No significant changeSerum calcium
Study
n = 9
Comparator
Placebo
Outcome group
Electrolyte balance · Endocrine and hormones
Studied dose
0.5 mg bolus followed by 1.5 mg infusion · intravenous · 90 minutesAs given in this study (human).
Source sentences
Summary
Glucagon did not significantly change the serum calcium level
2 context sentences(design, population, supporting numbers)
Summary · context
In a double-blind placebo-controlled study the effect of glucagon on gastric emptying, as well as on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after ingestion of a mixed solid-liquid meal was examined in nine normal males.
Summary · context
An i.v. bolus of 0.5 mg of crystalline glucagon was followed by 1.5 mg infused at a constant rate over 90 minutes.
Report a problemFND-0248847207
08HumanNon-randomized trialEfficacy outcome
In normal males, glucagon lowered serum phosphorus throughout infusion versus placebo.
In plain wordsIn normal males, glucagon lowered blood phosphorus during infusion compared with placebo.
Peptide
Glucagon
Outcome
DecreaseSerum phosphorus
Study
n = 9
Comparator
Placebo
Outcome group
Electrolyte balance · Endocrine and hormones
Studied dose
0.5 mg bolus followed by 1.5 mg infusion · intravenous · 90 minutesAs given in this study (human).
Source sentences
Summary
whereas the serum phosphorus concentration was markedly lowered throughout glucagon infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
In a double-blind placebo-controlled study the effect of glucagon on gastric emptying, as well as on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after ingestion of a mixed solid-liquid meal was examined in nine normal males.
Summary · context
An i.v. bolus of 0.5 mg of crystalline glucagon was followed by 1.5 mg infused at a constant rate over 90 minutes.
Report a problemFND-0248847208

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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