Thymosin-beta 4 concentrations during the estrous cycle and after hypophyseal stalk transection of female pigs.

Ford JJ, Vakharia DD, Anderson LL, Klindt J

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)1 Mar 1990Cited by 5 (Europe PMC)

PMID2406726DOI10.3181/00379727-193-43023PepBankPUB-02406726

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In female pigs, circulating thymosin beta‑4 rose significantly on the day of weaning, during follicular development and during early luteal formation.
In plain wordsIn pigs, the body's own thymosin beta‑4 in blood rose around weaning, follicle growth and early corpus luteum formation.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseThB4 at weaning, follicular development and early luteal formation
Study
pign: not reported in source
female pigs after weaning
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Significant increases in ThB4 were observed during the day of weaning, during follicular development, and during early luteal formation.
1 context sentence(design, population, supporting numbers)
Summary · context
Thymosin-beta 4 (ThB4) concentrations in the peripheral circulation of pigs were investigated during the first 30 days after weaning and after hypophyseal stalk transection of ovariectomized females.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240672601
02AnimalEndogenous levelAnimal study (in vivo)Other
During the first period of follicular development (Days 1 to 5 after weaning), thymosin beta‑4 was uniformly elevated for 3 days.
In plain wordsIn pigs, the body's own thymosin beta‑4 stayed raised for 3 days in the first follicle growth period after weaning.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseThB4 during first follicular development (Days 1 to 5)
Study
pign: not reported in source
female pigs after weaning
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
duration of elevation
3 days
Days 1 to 5 after weaning
Source sentences
Summary
During the first period of follicular development (Days 1 to 5 after weaning), ThB4 was uniformly elevated for 3 days
1 context sentence(design, population, supporting numbers)
Summary · context
Thymosin-beta 4 (ThB4) concentrations in the peripheral circulation of pigs were investigated during the first 30 days after weaning and after hypophyseal stalk transection of ovariectomized females.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240672602
03AnimalEndogenous levelAnimal study (in vivo)Other
During the second period of follicular development (days 21 to 25 after weaning), the increase in thymosin beta‑4 was bimodal.
In plain wordsIn pigs, the body's own thymosin beta‑4 rose in two peaks in the second follicle growth period after weaning.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseThB4 during second follicular development (days 21 to 25)
Study
pign: not reported in source
female pigs after weaning
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
whereas during the second period of follicular development (days 21 to 25 after weaning), the increase in ThB4 was bimodal.
1 context sentence(design, population, supporting numbers)
Summary · context
Thymosin-beta 4 (ThB4) concentrations in the peripheral circulation of pigs were investigated during the first 30 days after weaning and after hypophyseal stalk transection of ovariectomized females.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240672603
04AnimalEndogenous levelAnimal study (in vivo)Other
Thymosin beta‑4 concentrations were low during the luteal phase, when progesterone concentrations were at their greatest.
In plain wordsIn pigs, the body's own thymosin beta‑4 in blood was low during the luteal phase.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseThB4 during the luteal phase
Study
pign: not reported in source
female pigs after weaning
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
ThB4 concentrations were low during the luteal phase when progesterone concentrations were at their greatest.
1 context sentence(design, population, supporting numbers)
Summary · context
Thymosin-beta 4 (ThB4) concentrations in the peripheral circulation of pigs were investigated during the first 30 days after weaning and after hypophyseal stalk transection of ovariectomized females.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240672604
05AnimalEndogenous levelAnimal study (in vivo)Other
In ovariectomized pigs, with or without hypophyseal stalk transection, a single intravenous injection of luteinizing hormone-releasing hormone did not acutely change thymosin beta‑4 concentrations.
In plain wordsIn pigs without ovaries, an injection of luteinizing hormone-releasing hormone did not change the body's own thymosin beta‑4 in blood.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeThB4 after luteinizing hormone-releasing hormone injection
Study
pign: not reported in source
ovariectomized pigs, with or without hypophyseal stalk transection
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In ovariectomized pigs, ThB4 concentrations were not influenced acutely by a single intravenous injection (2 micrograms) of luteinizing hormone-releasing hormone in control (hypophyseal stalk intact) or hypophyseal stalk transected females.
1 context sentence(design, population, supporting numbers)
Summary · context
Thymosin-beta 4 (ThB4) concentrations in the peripheral circulation of pigs were investigated during the first 30 days after weaning and after hypophyseal stalk transection of ovariectomized females.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240672605

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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